INT36489

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Context Info
Confidence 0.58
First Reported 1988
Last Reported 2009
Negated 4
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 10.60
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Apcs) extracellular region (Apcs) protein complex assembly (Apcs)
protein complex (Apcs)
Anatomy Link Frequency
blood 2
RVLM 1
occipital cortex 1
heart 1
Apcs (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Action potential 7 100.00 Very High Very High Very High
cytokine 10 99.98 Very High Very High Very High
Inflammation 27 99.96 Very High Very High Very High
Rostral ventrolateral medulla 132 98.66 Very High Very High Very High
antagonist 13 98.34 Very High Very High Very High
agonist 17 97.18 Very High Very High Very High
Spinal cord 3 96.76 Very High Very High Very High
Inflammatory mediators 37 95.56 Very High Very High Very High
Clonidine 2 92.56 High High
cva 5 92.44 High High
Disease Link Frequency Relevance Heat
Pancreatitis 235 100.00 Very High Very High Very High
Myocardial Infarction 76 99.96 Very High Very High Very High
INFLAMMATION 71 99.96 Very High Very High Very High
Obstructive Jaundice 181 99.80 Very High Very High Very High
Death 106 99.40 Very High Very High Very High
Frailty 12 99.38 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 2 97.00 Very High Very High Very High
Muscular Spasm 3 95.00 High High
Cv General 4 Under Development 3 92.44 High High
Brain Injury 6 91.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mixed 5-HT/NA uptake inhibitor imipramine did not significantly affect SAP or intentions, but reduced crossings.
Neg (not) Regulation (affect) of SAP
1) Confidence 0.58 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8539344 Disease Relevance 0.07 Pain Relevance 0.35
Some clinical studies have shown that salvia miltiorrhizae, as an auxiliary drug, has some therapeutic effects on SAP and OJ.
Regulation (effects) of SAP associated with pancreatitis and obstructive jaundice
2) Confidence 0.49 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2822241 Disease Relevance 1.61 Pain Relevance 0.22
Some clinical studies have shown that Salvia miltiorrhizae, as an auxiliary drug, have some therapeutic effects on SAP and OJ.
Regulation (effects) of SAP associated with pancreatitis and obstructive jaundice
3) Confidence 0.36 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2790077 Disease Relevance 1.32 Pain Relevance 0.17
To sum up, Salvia miltiorrhizae injection can exert protective effects on the spleen and thymus of SAP rats and the spleen of OJ rats through reducing the contents of endotoxin and PLA2 in blood, improving the pathological damage present in the spleen and thymus of SAP rats and the spleen of OJ rats, and inhibiting the expression of Bax protein in the spleen of OJ rats and the apoptosis.
Regulation (effects) of SAP in blood associated with pancreatitis, apoptosis and obstructive jaundice
4) Confidence 0.30 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2790077 Disease Relevance 1.63 Pain Relevance 0.09
Some studies have proven that the tanshinol contained in Salvia miltiorrhizae can exert therapeutic effects on SAP and OJ through a variety of pharmacological actions [17–20].
Regulation (effects) of SAP associated with pancreatitis and obstructive jaundice
5) Confidence 0.26 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2790077 Disease Relevance 1.25 Pain Relevance 0.06
The 5-HT2C/1B receptor agonist m-CPP, the inverse BZD receptor agonists FG 7142 and DMCM, and the alpha 2-adrenoceptor antagonist yohimbine, to all of which putative anxiogenic effects have been ascribed, had no effect on SAP directed towards the prod. m-CPP, however, produced an increase in the stretched posture directed away from the prod (SAwayP).
Neg (no) Regulation (effect) of SAP associated with antagonist and agonist
6) Confidence 0.22 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8539344 Disease Relevance 0.07 Pain Relevance 0.46
Chronic bicucculine treatment, in contrast, had little or no homeostatic effect on SAP firing patterns; on the contrary, opposite to earlier findings using isolated occipital cortex explants, paroxysmal discharges persisted even after transfer to control medium.
Neg (little) Regulation (effect) of SAP in occipital cortex associated with action potential
7) Confidence 0.22 Published 2006 Journal Brain Res. Section Abstract Doc Link 16836981 Disease Relevance 0.18 Pain Relevance 0.39
MIV dose-dependently inhibited the increase in HR from 4.8 micrograms.kg-1.h-1 (68% reduction, P < 0.05) without affecting HR or SAP during anesthesia.
Neg (without) Regulation (affecting) of SAP
8) Confidence 0.20 Published 1998 Journal Acta Anaesthesiol Scand Section Body Doc Link 9509210 Disease Relevance 0 Pain Relevance 0
On intravenous administration of Mev, this animal model therefore allowed us to determine the temporal relationship between the elicited cardiac arrest, alterations in SAP, the life-and-death signal and tissue oxygen level, blood flow or temperature in the RVLM.
Regulation (alterations) of SAP in blood associated with rostral ventrolateral medulla, death and myocardial infarction
9) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766834 Disease Relevance 1.41 Pain Relevance 0.25
The RVLM is long known to play a crucial role in brain stem cardiovascular regulation [12], including maintenance of sympathetic vasomotor tone and stable SAP.
Regulation (regulation) of SAP in RVLM associated with rostral ventrolateral medulla
10) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766834 Disease Relevance 0.83 Pain Relevance 0.17
which is an important cytokine participates in SAP inflammatory
Regulation (participates) of SAP associated with inflammation, pancreatitis and cytokine
11) Confidence 0.12 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234334 Disease Relevance 1.38 Pain Relevance 0.44
The clip compression SCI rat model was used to measure changes in the mean systemic arterial pressure (mSAP), cardiac output (CO), heart rate (HR), total peripheral resistance (TPR), and central venous pressure (CVP) after SCI.
Regulation (changes) of mSAP in heart associated with frailty
12) Confidence 0.07 Published 1988 Journal J Trauma Section Abstract Doc Link 3352009 Disease Relevance 0.84 Pain Relevance 0.17

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