INT36499

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Context Info
Confidence 0.38
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.02
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tf) mitochondrion (Tf) extracellular space (Tf)
extracellular region (Tf) cytoplasmic membrane-bounded vesicle (Tf)
Anatomy Link Frequency
plasma 1
brains 1
T cell 1
Tf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
halothane 15 99.98 Very High Very High Very High
Morphine 6 97.92 Very High Very High Very High
Arthritis 6 95.90 Very High Very High Very High
Central grey 5 91.52 High High
Inflammatory response 1 89.36 High High
Dopamine 1 84.68 Quite High
cytokine 14 82.32 Quite High
Inflammation 9 76.72 Quite High
agonist 1 76.20 Quite High
cINOD 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 2 100.00 Very High Very High Very High
Congenital Anomalies 3 99.20 Very High Very High Very High
Coagulation Disorder 1 98.28 Very High Very High Very High
Restless Legs Syndrome 7 98.14 Very High Very High Very High
Urological Neuroanatomy 6 98.08 Very High Very High Very High
Experimental Arthritis 5 95.90 Very High Very High Very High
INFLAMMATION 12 89.36 High High
Alzheimer's Dementia 2 86.80 High High
Necrosis 1 80.96 Quite High
Cancer 14 80.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Urea production did not differ in the two treatment groups, but halothane depressed albumin and transferrin synthesis 43% and 45%, respectively.
Negative_regulation (depressed) of transferrin associated with halothane
1) Confidence 0.38 Published 1988 Journal Anesthesiology Section Abstract Doc Link 3354889 Disease Relevance 0 Pain Relevance 0.50
The effect of adjuvant arthritis (AA) on the pattern of rat serum proteins includes the upregulation of haptoglobin, orosomucoid, alpha2-macroglobulin, serine protease inhibitor-3, thiostatin, alpha1-antitrypsin, C-reactive protein, and the downregulation of kallikrein-binding protein, alpha1-inhibitor III, apolipoprotein A-I, alpha2-HS-glycoprotein, albumin, apolipoprotein A-IV, transthyretin and transferrin.
Negative_regulation (downregulation) of transferrin associated with experimental arthritis, disorder of lipid metabolism and arthritis
2) Confidence 0.32 Published 2000 Journal Electrophoresis Section Abstract Doc Link 10892728 Disease Relevance 0.98 Pain Relevance 0.51
Inhibition of interleukin-2 production and downregulation of IL-2 and transferrin receptors on rat splenic lymphocytes following PAG morphine administration: a role in natural killer and T cell suppression.
Negative_regulation (Inhibition) of transferrin in T cell associated with urological neuroanatomy and morphine
3) Confidence 0.15 Published 1999 Journal J. Interferon Cytokine Res. Section Title Doc Link 10433363 Disease Relevance 0.43 Pain Relevance 0.65
Particularly large or diffuse spots, such as those likely containing multiple proteins or representing albumin and/or transferrin, were not considered good candidates for quantitative analysis by MS and were excluded from further analysis.


Negative_regulation (representing) of transferrin
4) Confidence 0.12 Published 2007 Journal Respir Res Section Body Doc Link PMC1876226 Disease Relevance 0 Pain Relevance 0
These signaling cascades result in increased plasma levels of a number of positive acute-phase proteins (APPs), including clotting proteins, transport proteins, antiproteases, and complement factors, with a parallel decrease in negative APPs, such as albumin or transferrin (Ramadori and Christ 1999).
Negative_regulation (decrease) of transferrin in plasma associated with coagulation disorder
5) Confidence 0.06 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0.58 Pain Relevance 0.11
Neuropathological examination of brains from RLS patients revealed no histopathological abnormalities, but did show that iron, ferritin, and transferrin receptor staining all were markedly decreased in substania nigra cells, while transferrin staining was increased and tyrosine hydroxylase was present at normal levels, suggesting that RLS may be a functional disorder of iron processing in these neuromelanin cells that impairs the dopaminergic system (Connor et al., 2003).


Negative_regulation (decreased) of transferrin in brains associated with congenital anomalies and restless legs syndrome
6) Confidence 0.03 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC2995617 Disease Relevance 1.03 Pain Relevance 0.08

General Comments

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