INT36502

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Context Info
Confidence 0.40
First Reported 1985
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 12
Disease Relevance 6.26
Pain Relevance 4.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
IAS 5
BCM 1
nerve 1
EAS 1
EAS 1
asp1 (Mus musculus)
Pain Link Frequency Relevance Heat
noradrenaline 12 99.84 Very High Very High Very High
nerve block 3 99.12 Very High Very High Very High
tetrodotoxin 8 98.92 Very High Very High Very High
Endogenous opioid 4 98.52 Very High Very High Very High
Piles 21 96.40 Very High Very High Very High
Abstinence syndrome 4 96.12 Very High Very High Very High
Opioid 4 95.36 Very High Very High Very High
agonist 2 94.56 High High
Snapping jaw 224 93.28 High High
imagery 74 90.32 High High
Disease Link Frequency Relevance Heat
Syndrome 12 100.00 Very High Very High Very High
Frailty 2 99.16 Very High Very High Very High
Pressure And Volume Under Development 4 98.38 Very High Very High Very High
Incontinence 6 98.16 Very High Very High Very High
Anorectal Disorders 21 96.40 Very High Very High Very High
Aggression 2 93.44 High High
Temporomandibular Joint Syndrome 224 93.28 High High
Disease 84 89.52 High High
Arthritis 98 84.48 Quite High
Juvenile Chronic Polyarthritis 108 83.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They induced an IAS in rats, by means of specific sound signals and examined the animals' behaviour by a test used in the study of the opioid abstinence syndrome, as well as their reaction to noxious stimuli by means of thermal stimulation.
Spec (examined) Positive_regulation (induced) of IAS associated with syndrome, opioid and abstinence syndrome
1) Confidence 0.40 Published 1988 Journal Int. J. Neurosci. Section Abstract Doc Link 3356503 Disease Relevance 0.97 Pain Relevance 0.86
IAS contraction induced by NA was resistant to propranolol, atropine, hexamethonium and tetrodotoxin, but blocked by phentolamine and yohimbine.
Positive_regulation (induced) of IAS in IAS associated with tetrodotoxin and noradrenaline
2) Confidence 0.40 Published 1985 Journal Acta Med. Okayama Section Abstract Doc Link 3984781 Disease Relevance 0 Pain Relevance 0.53
Phenylephrine also induced rectal and IAS contraction.
Positive_regulation (induced) of IAS in IAS
3) Confidence 0.40 Published 1985 Journal Acta Med. Okayama Section Abstract Doc Link 3984781 Disease Relevance 0 Pain Relevance 0.51
Significant HO activity was detected in the IAS, which increased further in response to NANC nerve stimulation and VIP.
Positive_regulation (increased) of IAS in IAS
4) Confidence 0.15 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8238364 Disease Relevance 0 Pain Relevance 0.12
Significant HO activity was detected in the IAS, which increased further in response to NANC nerve stimulation and VIP.
Positive_regulation (detected) of IAS in IAS
5) Confidence 0.15 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8238364 Disease Relevance 0 Pain Relevance 0.12
Systemic medication use in this cohort was not reported; however, a substantial number of patients had splinting and none of these patients underwent IAS during the study period.
Positive_regulation (underwent) of IAS
6) Confidence 0.15 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2694194 Disease Relevance 1.01 Pain Relevance 0.54
Thus, while increased IAS tone in the ATR protects against involuntary incontinence upon 'slow' rectal filling, the increased EAS tone of Gower's reflex protects in the case of 'rapid' filling.
Positive_regulation (increased) of IAS in EAS associated with incontinence
7) Confidence 0.11 Published 1993 Journal Eur Surg Res Section Abstract Doc Link 8276040 Disease Relevance 0.37 Pain Relevance 0.09
Pudendal nerve block and phentolamine administration revealed that this pressure increase is due to increased IAS tone which tightens the RN against the slow rectal filling by the time adaptive reaction occurs.
Positive_regulation (increased) of IAS in nerve associated with nerve block
8) Confidence 0.11 Published 1993 Journal Eur Surg Res Section Abstract Doc Link 8276040 Disease Relevance 0.29 Pain Relevance 0.10
In normal subjects, the RN pressure increased upon slow rectal inflation; the IAS EMG was augmented.
Positive_regulation (augmented) of IAS in IAS
9) Confidence 0.11 Published 1993 Journal Eur Surg Res Section Abstract Doc Link 8276040 Disease Relevance 0.28 Pain Relevance 0.10
Adverse events were rare in both series and included transient facial swelling in 2 patients and subcutaneous atrophy at the injection site in one patient who underwent 5 IAS.
Positive_regulation (underwent) of IAS associated with pressure and volume under development and frailty
10) Confidence 0.10 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2694194 Disease Relevance 0.94 Pain Relevance 0.69
The bulbocavernosus reflex as well as EMG activity of EAS and BCM were normal, while the resting EMG activity of the IAS was increased.
Positive_regulation (increased) of IAS in EAS
11) Confidence 0.03 Published 2000 Journal Int. J. Impot. Res. Section Abstract Doc Link 11424966 Disease Relevance 1.16 Pain Relevance 0.40
The bulbocavernosus reflex as well as EMG activity of EAS and BCM were normal, while the resting EMG activity of the IAS was increased.
Positive_regulation (increased) of IAS in BCM
12) Confidence 0.01 Published 2000 Journal Int. J. Impot. Res. Section Abstract Doc Link 11424966 Disease Relevance 1.16 Pain Relevance 0.40

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