INT36529

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Context Info
Confidence 0.69
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 39
Total Number 39
Disease Relevance 12.05
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
microglia 4
joint 2
brain 2
upper 1
T cells 1
Mela (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 33 99.42 Very High Very High Very High
Central nervous system 510 97.68 Very High Very High Very High
cytokine 38 97.40 Very High Very High Very High
Arthritis 5 94.16 High High
Multiple sclerosis 12 93.16 High High
chemokine 11 92.28 High High
cINOD 8 85.76 High High
ketamine 10 74.40 Quite High
anesthesia 58 73.68 Quite High
Demyelination 4 71.60 Quite High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 505 100.00 Very High Very High Very High
Pox Virus Infection 9 99.72 Very High Very High Very High
Contagious Ecthyma 8 99.44 Very High Very High Very High
INFLAMMATION 39 99.42 Very High Very High Very High
Arthritis 17 99.20 Very High Very High Very High
Immunization 220 98.48 Very High Very High Very High
Infection 1442 98.44 Very High Very High Very High
Disease 228 98.40 Very High Very High Very High
Viremia 64 97.68 Very High Very High Very High
Testicular Cancer 4 94.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, given that the relative Env expression levels were variable on different cells in the same culture (e.g., figure 1B), this finding was not particularly surprising.
Gene_expression (expression) of Env
1) Confidence 0.69 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0 Pain Relevance 0
Immunochemical staining for Env expression in microglia was carried out as previously described [32] using monoclonal antibody 697 for FrCasE, and a goat anti-Friend MLV Env for Fr57E (a generous gift from R.
Gene_expression (expression) of Env in microglia
2) Confidence 0.69 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0 Pain Relevance 0
Examination of the mixed glial cultures by indirect immunofluorescence microscopy demonstrated the presence of abundant mature and immature astrocytes (GFAP+), nestin+ cells, neurofilament 68+ cells, and a few oligodendroglia (olig 2+ and galactocerebroside+) and significant microglia (RCA-1+, Mac-1+, F4/80Lo), all of which showed coincident expression of the Env from the infecting virus.
Gene_expression (expression) of Env in oligodendroglia
3) Confidence 0.69 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.06 Pain Relevance 0.03
Despite the apparent size differences between FrCasE and Fr57E Envs, both Env proteins appear to be efficiently expressed and readily trafficked to the cell surface, as shown by the immuonflourescence staining analysis (figure 1B, left panels).
Gene_expression (expressed) of Env
4) Confidence 0.69 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0 Pain Relevance 0
Western Blotting of microglial samples for Env and Gag expression were carried out as described previously [32].
Gene_expression (expression) of Env
5) Confidence 0.69 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0 Pain Relevance 0
The relative levels of Env protein being expressed in the various cultures appeared to be somewhat variable in contrast to the levels of pr65gag (see below), which were more consistent between cultures.
Gene_expression (expressed) of Env protein
6) Confidence 0.69 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0 Pain Relevance 0
Similarly, no enhancement of drug effect was seen when arthritic cartilage was taken from an acutely inflamed joint, and prenisolone sodium phosphate even seemed to diminish inflammation-mediated suppression of 35S-GAG synthesis.
Gene_expression (synthesis) of GAG in joint associated with inflammation and arthritis
7) Confidence 0.65 Published 1988 Journal Drugs Section Abstract Doc Link 3359944 Disease Relevance 0.68 Pain Relevance 0.45
Cell surface immunostaining of the isolated microglial cells with monoclonal antibodies directed against the respective viral Env proteins showed that the isolated microglial cells were essentially all positive for either FrCasE or Fr57E Env expression compared to mock-infected controls (Figure 1B).
Gene_expression (expression) of Env in microglial cells
8) Confidence 0.60 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.27 Pain Relevance 0
For example, in susceptible mice transplanted with NSCs expressing CasBrE Env, no neuropathological changes were observed within the 4 week assay period [17].
Gene_expression (expressing) of Env
9) Confidence 0.60 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.55 Pain Relevance 0.13
This result suggests that Env protein processing differs between microglia and fibroblasts, a finding analogous to that previously noted when FrCasE-infected microglia and mixed glia were compared [32].
Gene_expression (processing) of Env protein in microglia
10) Confidence 0.60 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.06 Pain Relevance 0
The relative levels of Env protein being expressed in the various cultures appeared to be somewhat variable in contrast to the levels of pr65gag (see below), which were more consistent between cultures.
Gene_expression (levels) of Env protein
11) Confidence 0.60 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0 Pain Relevance 0
Only sodium salicylate suppressed in vivo 35S-GAG synthesis in the healthy and arthritic joint to the same extent in both.
Gene_expression (synthesis) of GAG in joint associated with arthritis
12) Confidence 0.58 Published 1988 Journal Drugs Section Abstract Doc Link 3359944 Disease Relevance 0.75 Pain Relevance 0.41
Interestingly, the level of surface Env and/or microglial marker expression in the isolated microglia was highly variable from cell to cell regardless of virus infection.
Gene_expression (expression) of Env in microglia associated with infection
13) Confidence 0.54 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.22 Pain Relevance 0
Western blotting with the CasBrE-Env specific antibody 697 (figure 2C, upper panel, right side) confirmed that the predominant CasBrE Env species in microglia was indeed a slowly migrating protein corresponding to the Env precursor protein.
Gene_expression (species) of Env in upper
14) Confidence 0.52 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0 Pain Relevance 0
In this regard, it has been observed that NV Env proteins do not appear to specify unique cell tropism, as similar CNS cell type infection, including microglial infection, has been observed between closely related NNs and NVs [12,22].
Gene_expression (proteins) of Env associated with central nervous system and infection
15) Confidence 0.52 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.65 Pain Relevance 0.18
Furthermore, experiments in which chimeric brains were generated using NSCs expressing either replication restricted NVs (limited to binding, entry and reverse transcription in host target cells); or defective virus encoding the CasBrE env gene, acute neuropathological changes were not observed [16,17].
Gene_expression (expressing) of env in brains
16) Confidence 0.52 Published 2006 Journal Retrovirology Section Body Doc Link PMC1475625 Disease Relevance 0.61 Pain Relevance 0.04
This was achieved by assaying Env expression 48 hours after giving SpFr or SpFr-IC to BMDCs.
Gene_expression (expression) of Env
17) Confidence 0.51 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2883599 Disease Relevance 0.43 Pain Relevance 0
Thus, rather than enhancing the number of DCs expressing viral Env in vivo, the treatment by 667 diminishes it, presumably because reduced viral spread in infected/treated mice limits infection of DC precursors.
Gene_expression (expressing) of Env associated with infection
18) Confidence 0.51 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2883599 Disease Relevance 0.51 Pain Relevance 0
Co-expression of Env, CD11c and MHC-II on splenic DCs was assessed by flow cytometry 8, 15 and 35 post-infection after preparation of splenocytes from sacrificed mice.


Gene_expression (Co-expression) of Env associated with infection
19) Confidence 0.51 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2883599 Disease Relevance 0.10 Pain Relevance 0
Another group of putative MuERVs, defective in their genome structures, had intact coding potentials for gag, pol, and/or env polypeptides and it is likely that changes in the expression of these individual proteins affect the host cells' normal physiology, such as overexpression of syncytin in the brain of multiple sclerosis patients.
Gene_expression (polypeptides) of env in brain associated with multiple sclerosis
20) Confidence 0.48 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2241634 Disease Relevance 0.52 Pain Relevance 0.05

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