INT36534

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Context Info
Confidence 0.56
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.39
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (PLOD1) endoplasmic reticulum (PLOD1)
Anatomy Link Frequency
plasma 2
pituitary 2
PLOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 19 100.00 Very High Very High Very High
Dopamine 5 99.76 Very High Very High Very High
opiate 3 94.84 High High
antagonist 1 90.92 High High
imagery 1 89.36 High High
Opioid 7 88.56 High High
dopamine receptor 3 86.52 High High
Enkephalin 2 79.60 Quite High
Endogenous opioid 2 76.36 Quite High
Clonidine 1 59.60 Quite High
Disease Link Frequency Relevance Heat
Stress 2 98.58 Very High Very High Very High
Brain Injury 2 96.84 Very High Very High Very High
Diabetes Insipidus 1 87.16 High High
Injury 2 84.60 Quite High
Cyst 1 78.80 Quite High
Hypopituitarism 3 77.24 Quite High
Cancer 3 76.88 Quite High
Precocious Puberty 4 72.00 Quite High
Obesity 5 68.56 Quite High
Insulin Resistance 1 67.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Melatonin did not affected LH serum levels, while it was able to reduce LH increase induced by naloxone.
Negative_regulation (reduce) of Positive_regulation (increase) of LH associated with narcan
1) Confidence 0.56 Published 1988 Journal J. Endocrinol. Invest. Section Abstract Doc Link 3361078 Disease Relevance 0 Pain Relevance 0.70
Naloxone caused a significant increase in luteinizing hormone (LH) (P less than 0.05); in these subjects, clomiphene treatment significantly increased LH and follicle-stimulating hormone plasma levels but totally suppressed the naloxone-induced rise in LH.
Negative_regulation (suppressed) of Positive_regulation (naloxone-induced) of LH in plasma associated with narcan
2) Confidence 0.33 Published 1983 Journal Fertil. Steril. Section Abstract Doc Link 6317469 Disease Relevance 0 Pain Relevance 0.54
The infusion of dopamine completely suppressed the naloxone-induced LH rise; on the contrary, metoclopramide failed to alter the magnitude of the increments in LH observed during the infusion of the opiate blocker.
Negative_regulation (suppressed) of Positive_regulation (naloxone-induced) of LH associated with dopamine, narcan and opiate
3) Confidence 0.23 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6847869 Disease Relevance 0 Pain Relevance 0.80
Three months after the head injury, the hormonal evaluation of the hypothalamic-pituitary axis by means of insulin stress test with the simultaneous administration of TRH and GnRH resulted in reduced responses of GH, cortisol, TSH, FSH, and LH with low baseline serum concentrations of free T4 and testosterone.
Negative_regulation (reduced) of Positive_regulation (responses) of LH in pituitary associated with stress and brain injury
4) Confidence 0.17 Published 1996 Journal J. Endocrinol. Invest. Section Abstract Doc Link 8796342 Disease Relevance 0.81 Pain Relevance 0.10
For example, atrazine delays puberty in both males and females, reducing circulating LH and prolactin [64].
Negative_regulation (reducing) of Positive_regulation (circulating) of LH
5) Confidence 0.05 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2958977 Disease Relevance 0.57 Pain Relevance 0

General Comments

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