INT36536

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Context Info
Confidence 0.24
First Reported 1988
Last Reported 1988
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.86
Pain Relevance 4.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PRSS1, PENK) signal transduction (PENK) peptidase activity (PRSS1)
extracellular space (PRSS1)
PRSS1 (Homo sapiens)
PENK (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 54 100.00 Very High Very High Very High
Catecholamine 9 87.40 High High
Endogenous opioid 3 53.36 Quite High
Disease Link Frequency Relevance Heat
Pheochromocytoma 6 90.72 High High
Cancer 3 83.04 Quite High
Adrenal Cancer 3 76.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Enkephalin immunoreactivity was augmented by trypsin alone and by trypsin plus carboxypeptidase B (by 352 +/- 56%), suggesting that the majority of the enkephalins were present in higher molecular weight precursor form.
trypsin Positive_regulation (augmented) of Enkephalin associated with enkephalin
1) Confidence 0.24 Published 1988 Journal J. Hypertens. Section Abstract Doc Link 3361117 Disease Relevance 0.27 Pain Relevance 1.53
Enkephalin immunoreactivity was augmented by trypsin alone and by trypsin plus carboxypeptidase B (by 352 +/- 56%), suggesting that the majority of the enkephalins were present in higher molecular weight precursor form.
trypsin Positive_regulation (augmented) of Enkephalin associated with enkephalin
2) Confidence 0.24 Published 1988 Journal J. Hypertens. Section Abstract Doc Link 3361117 Disease Relevance 0.27 Pain Relevance 1.53
Sephacryl S-200 gel filtration of chromaffin granule lysate revealed a trypsin-augmented putative human enkephalin precursor with a molecular weight of 2000-4000 daltons as well as product enkephalins.
trypsin Positive_regulation (augmented) of enkephalin associated with enkephalin
3) Confidence 0.21 Published 1988 Journal J. Hypertens. Section Abstract Doc Link 3361117 Disease Relevance 0.32 Pain Relevance 1.33

General Comments

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