INT36554

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Context Info
Confidence 0.78
First Reported 1982
Last Reported 2011
Negated 4
Speculated 1
Reported most in Body
Documents 70
Total Number 74
Disease Relevance 50.25
Pain Relevance 15.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PRSS1) extracellular space (PRSS1) extracellular region (PRSS1)
Anatomy Link Frequency
pancreas 5
acinar cells 3
plasma 1
exocrine pancreas 1
stellate cell 1
PRSS1 (Homo sapiens)
PRSS1 - R117H (2) PRSS1 - R122H (2)
Pain Link Frequency Relevance Heat
gABA 123 100.00 Very High Very High Very High
Catecholamine 15 100.00 Very High Very High Very High
Serotonin 6 100.00 Very High Very High Very High
alcohol 44 99.90 Very High Very High Very High
spastic colon 220 99.84 Very High Very High Very High
Chronic pancreatitis 1250 99.82 Very High Very High Very High
agonist 16 99.40 Very High Very High Very High
Cholecystokinin 5 99.20 Very High Very High Very High
fibrosis 163 99.08 Very High Very High Very High
Neurotransmitter 93 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 57 100.00 Very High Very High Very High
Pancreatitis 2100 99.98 Very High Very High Very High
Targeted Disruption 186 99.98 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

217 99.84 Very High Very High Very High
Cough 13 99.80 Very High Very High Very High
Cancer 193 99.76 Very High Very High Very High
Inflammatory Bowel Disease 151 99.68 Very High Very High Very High
Viral Infection 1 99.64 Very High Very High Very High
Pancreatic Cancer 278 99.42 Very High Very High Very High
Cystic Fibrosis 150 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the normal pancreas and in the histologically normal areas of the inflamed pancreas, trypsin was detected in the zymogen granules of acinar cells and in ductal secretory material.
Gene_expression (detected) of trypsin in acinar cells
1) Confidence 0.78 Published 1983 Journal Digestion Section Abstract Doc Link 6350076 Disease Relevance 0.34 Pain Relevance 0.24
Our group developed a mouse expressing R122H human trypsinogen in the exocrine pancreas by using the rat elastase-2 promoter [71].
Gene_expression (expressing) of trypsinogen in exocrine pancreas
2) Confidence 0.76 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.84 Pain Relevance 0.13
Thus, this animal model, which gives a significant expression level of R122H mutated trypsinogen, seems to recapitulate the human disease.
Gene_expression (expression) of trypsinogen associated with disease
3) Confidence 0.76 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 1.11 Pain Relevance 0.19
Transgenic expression of the R122H mutation of murine trypsin 4 in mouse pancreas led to progressive fibrosis and chronic inflammation of the pancreas [72].
Gene_expression (expression) of trypsin in pancreas associated with targeted disruption, fibrosis and inflammation
4) Confidence 0.76 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 1.06 Pain Relevance 0.17
However, the recombinant expression of human trypsinogen is difficult and has been carried out by only two groups worldwide, with partially conflicting results due to different analytical conditions [8,15].
Gene_expression (expression) of trypsinogen
5) Confidence 0.76 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC117221 Disease Relevance 0.20 Pain Relevance 0.05
Knowledge of the pathophysiological conditions leading to acute and chronic pancreatitis and the development of a transgenic mouse expressing the mutant human trypsinogen genes will provide directions and tools necessary for the effective treatment or prevention of this human disease.
Gene_expression (expressing) of trypsinogen associated with targeted disruption, disease and chronic pancreatitis
6) Confidence 0.75 Published 1999 Journal Baillieres Best Pract Res Clin Gastroenterol Section Abstract Doc Link 11030605 Disease Relevance 1.00 Pain Relevance 0.30
The disease gene was mapped and a heterozygous point mutation A>T in exon 3 (R122H) of the protease serine 1 (PRSS1) was detected in a majority (~70%) of cases with cationic trypsinogen mutations [4].
Gene_expression (detected) of PRSS1 associated with disease
7) Confidence 0.75 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317302 Disease Relevance 1.13 Pain Relevance 0.64
[Significance of trypsinogen gene mutations in the etiology of hereditary pancreatitis].
Gene_expression (mutations) of trypsinogen associated with pancreatitis
8) Confidence 0.68 Published 2001 Journal Orv Hetil Section Title Doc Link 11324217 Disease Relevance 0.59 Pain Relevance 0.10
These results show that the major protein present in pancreatic precipitates (and pancreatic stones) of patients with chronic pancreatitis is a degradation product of trypsinogen 1 liberated by a proteolysis which necessarily requires a premature zymogen activation in the disease.
Gene_expression (product) of trypsinogen 1 associated with disease and chronic pancreatitis
9) Confidence 0.68 Published 1984 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 6696753 Disease Relevance 0.36 Pain Relevance 0.26
Although it is well known that chronic pancreatitis is predisposed by heterozygosity for CFTR mutations, little is known about the combination of CFTR mutations with PRSS1 or SPINK1 mutations.
Gene_expression (mutations) of PRSS1 associated with chronic pancreatitis
10) Confidence 0.67 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2970583 Disease Relevance 0.48 Pain Relevance 0.10
The mild phenotype in these animals is probably caused by a low expression level of R122H mutated trypsinogen.
Gene_expression (expression) of trypsinogen
11) Confidence 0.67 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.99 Pain Relevance 0.17
The trypsinogen und SPINK1 mutation database
Gene_expression (database) of trypsinogen
12) Confidence 0.66 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.96 Pain Relevance 0.20
N29I and enhanced trypsinogen autoactivation
Gene_expression (autoactivation) of trypsinogen
13) Confidence 0.66 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.21 Pain Relevance 0
Taken together, the pancreatic cancer risk in HCP patients with a PRSS1 mutation seems to be elevated – with an uncertain relative risk increase.
Gene_expression (mutation) of PRSS1 associated with pancreatic cancer and chronic pancreatitis
14) Confidence 0.66 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 1.82 Pain Relevance 0.74
Beyond the hitherto discussed aspects the detection of PRSS1 and SPINK1 mutations will lead to a correct classification of the disease, helping the affected individual to better understand their disease and clearing out misclassifications (e.g. alcoholic chronic pancreatitis).
Gene_expression (detection) of PRSS1 associated with disease and chronic pancreatitis
15) Confidence 0.66 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.82 Pain Relevance 0.30
R122H and increased trypsin stability
Gene_expression (stability) of trypsin
16) Confidence 0.66 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.59 Pain Relevance 0.15
The indication for PRSS1 and SPINK1 mutation testing in symptomatic patients should be one of the following:
Gene_expression (testing) of PRSS1
17) Confidence 0.66 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.89 Pain Relevance 0.28
The investigation of the wild type trypsinogen molecule and three distinct mutants (i.e., N29I, N29T and R122H) found that cathepsin B mediated trypsinogen activation was not influenced by the respective mutants [8].
Gene_expression (activation) of trypsinogen
18) Confidence 0.65 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC117221 Disease Relevance 0.42 Pain Relevance 0.09
However, our investigations on the cleavability of the trypsinogen activation bond bond by active trypsin [3] and cathepsin B provide further evidence, that autoactivation rather than cathepsin B mediated trypsinogen activation is the key pathogenic event in the development of hereditary pancreatitis in D22G and K23R-carriers.
Gene_expression (cleavability) of trypsinogen associated with pancreatitis
19) Confidence 0.65 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC117221 Disease Relevance 0.55 Pain Relevance 0.07
Contribution of the CFTR gene, the pancreatic secretory trypsin inhibitor gene (SPINK1) and the cationic trypsinogen gene (PRSS1) to the etiology of recurrent pancreatitis.
Gene_expression (Contribution) of PRSS1 associated with pancreatitis
20) Confidence 0.65 Published 2007 Journal Clin. Genet. Section Title Doc Link 17489851 Disease Relevance 0.57 Pain Relevance 0.33

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