INT3656

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Context Info
Confidence 0.54
First Reported 1976
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 74
Total Number 78
Disease Relevance 44.94
Pain Relevance 17.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
plasma 20
skeletal muscle 8
nerve 8
muscle 7
liver 6
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
B1 receptor 275 100.00 Very High Very High Very High
Pain 32 100.00 Very High Very High Very High
qutenza 23 100.00 Very High Very High Very High
corticosteroid 64 99.98 Very High Very High Very High
withdrawal 24 99.98 Very High Very High Very High
Enkephalin 17 99.84 Very High Very High Very High
electroacupuncture 34 99.58 Very High Very High Very High
Dopamine 8 99.32 Very High Very High Very High
tramadol 8 98.68 Very High Very High Very High
Morphine 21 97.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
Insulin Resistance 433 100.00 Very High Very High Very High
Stress 283 100.00 Very High Very High Very High
Pressure And Volume Under Development 226 100.00 Very High Very High Very High
Hyperinsulinism 68 100.00 Very High Very High Very High
Pain 26 100.00 Very High Very High Very High
Atherosclerosis 22 100.00 Very High Very High Very High
Neuropathy 14 100.00 Very High Very High Very High
Ketosis 11 100.00 Very High Very High Very High
Diabetes Mellitus 996 99.98 Very High Very High Very High
Sepsis 315 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The latter regimen also decreased significantly increased plasma levels of insulin and glucose and insulin resistance (HOMA index) at 14 weeks.
Positive_regulation (increased) of Gene_expression (levels) of insulin in plasma associated with insulin resistance
1) Confidence 0.54 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17988733 Disease Relevance 1.38 Pain Relevance 0.53
This study showed that tramadol activated a neuronal insulin signaling cascade by increasing the induction of insulin receptor substrate-2 expression in primary cultured neuronal cells while this activation was suppressed by naloxone (MOR inhibitor) and dexamethasone (non-specific inhibitor of MOR and 5-HT receptor, DEX).
Positive_regulation (induction) of Gene_expression (expression) of insulin in neuronal associated with tramadol, mu opioid receptor, narcan and dexamethasone
2) Confidence 0.54 Published 2005 Journal Brain Res. Bull. Section Abstract Doc Link 16140165 Disease Relevance 0.09 Pain Relevance 0.88
The homeostasis model assessment index during IVGTT indicated an improvement in insulin sensitivity in GK rats treated with EA, whereas glucose infusion rate during hyperinsulinemic clamp was increased significantly during EA.
Positive_regulation (improvement) of Gene_expression (improvement) of insulin associated with electroacupuncture
3) Confidence 0.50 Published 2009 Journal Metab. Clin. Exp. Section Abstract Doc Link 19501858 Disease Relevance 0.45 Pain Relevance 0.68
A significant decrease in fasting blood glucose and an increase in plasma insulin levels were observed during the fasting period in GK rats treated with EA.
Positive_regulation (increase) of Gene_expression (levels) of insulin in plasma associated with electroacupuncture
4) Confidence 0.50 Published 2009 Journal Metab. Clin. Exp. Section Abstract Doc Link 19501858 Disease Relevance 0.46 Pain Relevance 0.66
Fructose-induced insulin resistance and hypertension in rats.
Positive_regulation (Fructose-induced) of Gene_expression (resistance) of insulin associated with hypertension and insulin resistance
5) Confidence 0.50 Published 1987 Journal Hypertension Section Title Doc Link 3311990 Disease Relevance 0.68 Pain Relevance 0.08
The change in blood glucose following ultrasound mediated insulin delivery was ?
Positive_regulation (delivery) of Gene_expression (delivery) of insulin in blood
6) Confidence 0.49 Published 2008 Journal International Journal of Nanomedicine Section Abstract Doc Link PMC2626935 Disease Relevance 0 Pain Relevance 0.09
The purpose of this study was to test the hypothesis that estrogen withdrawal increases insulin resistance and hypertension.
Positive_regulation (increases) of Gene_expression (resistance) of insulin associated with hypertension, insulin resistance and withdrawal
7) Confidence 0.49 Published 1996 Journal Am. J. Hypertens. Section Abstract Doc Link 8972891 Disease Relevance 0.64 Pain Relevance 0.19
Estrogen withdrawal in these animals also induces fasting and glucose-stimulated hyperinsulinemia, which are signs of worsening insulin resistance.
Positive_regulation (induces) of Gene_expression (resistance) of insulin associated with hyperinsulinism, insulin resistance and withdrawal
8) Confidence 0.49 Published 1996 Journal Am. J. Hypertens. Section Abstract Doc Link 8972891 Disease Relevance 0.74 Pain Relevance 0.27
Mortality in the insulin-treated group was 10% versus 28% in the untreated group.
Positive_regulation (treated) of Gene_expression (treated) of insulin
9) Confidence 0.49 Published 1987 Journal J. Surg. Res. Section Abstract Doc Link 3599982 Disease Relevance 0.65 Pain Relevance 0
This finding suggests that the dysfunction of the heart observed in diabetes may be caused by conspicuous alterations of myocardial metabolism caused by insulin deficiency, which can be reversed by means of exogenous replacement of the hormone.

?

Positive_regulation (caused) of Gene_expression (deficiency) of insulin in heart associated with diabetes mellitus
10) Confidence 0.49 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1698470 Disease Relevance 0.75 Pain Relevance 0.11
At plasma insulin levels of approximately 90 mU/l, CAP-rats showed a 21% increase in whole body glucose uptake compared with CON (24.4 +/- 1.6 vs 20.1 +/- 0.8 mg/kg min, p < 0.02), which was paralleled by a 20% increase in whole body glycolysis (12.6 +/- 0.8 vs 10.5 +/- 0.5 mg/ kg.min p < 0.05) (concentration of 3H2O in plasma).
Positive_regulation (increase) of Gene_expression (levels) of insulin in body associated with qutenza
11) Confidence 0.48 Published 1998 Journal Diabetologia Section Abstract Doc Link 9686923 Disease Relevance 0.24 Pain Relevance 0.70
Process in the insulin synthesis and secretion is disregulated and is related with the destruction of the ?
Positive_regulation (Process) of Gene_expression (synthesis) of insulin
12) Confidence 0.48 Published 2008 Journal Nutrition Research and Practice Section Body Doc Link PMC2788183 Disease Relevance 0.37 Pain Relevance 0
The activation of PI 3-kinase is required for insulin to stimulate glucose transport (44,45).
Positive_regulation (activation) of Gene_expression (required) of insulin
13) Confidence 0.47 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.46 Pain Relevance 0
The levels of serum glucose and immunoreactive insulin rapidly increased after the administration of capsaicin.
Positive_regulation (increased) of Gene_expression (levels) of insulin associated with qutenza
14) Confidence 0.46 Published 1986 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 2876434 Disease Relevance 0.06 Pain Relevance 0.74
We found that plasma immunoreactive glucagon concentrations significantly increased, whereas plasma immunoreactive insulin concentrations did not change significantly despite hyperglycemia.
Neg (not) Positive_regulation (change) of Gene_expression (concentrations) of insulin in plasma associated with hyperglycemia
15) Confidence 0.46 Published 1988 Journal Diabetes Section Abstract Doc Link 2891576 Disease Relevance 0.24 Pain Relevance 0.80
These results corresponded with an increase in the (pro)insulin biosynthesis under the same conditions.
Positive_regulation (increase) of Gene_expression (biosynthesis) of insulin
16) Confidence 0.42 Published 1990 Journal Biomed. Biochim. Acta Section Abstract Doc Link 2097989 Disease Relevance 0 Pain Relevance 0.74
Insulin produced a significant increase in glucagon levels, and GLP-1 analog produced a significant increase in insulin levels without any change in other glucoregulatory and stress hormone levels.
Positive_regulation (increase) of Gene_expression (produced) of Insulin associated with stress
17) Confidence 0.42 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16280413 Disease Relevance 0.97 Pain Relevance 0.18
Insulin (1 IU, I.P.) produced in healthy rats significant increases in pancreatic flow rate, amylase secretion and protein output compared to basal (p < 0.05).
Positive_regulation (increases) of Gene_expression (produced) of Insulin
18) Confidence 0.40 Published 2004 Journal Mol. Cell. Biochem. Section Abstract Doc Link 15362492 Disease Relevance 0.37 Pain Relevance 0
These all changes observed in STZ-diabetic rats were significantly reversed by daily injection of insulin.
Positive_regulation (injection) of Gene_expression (injection) of insulin associated with diabetes mellitus
19) Confidence 0.39 Published 1997 Journal Life Sci. Section Abstract Doc Link 9126871 Disease Relevance 0.82 Pain Relevance 0.06
The latter regimen also decreased significantly increased plasma levels of insulin and glucose and insulin resistance (HOMA index) at 14 weeks.
Positive_regulation (increased) of Gene_expression (levels) of insulin in plasma associated with insulin resistance
20) Confidence 0.39 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17988733 Disease Relevance 1.37 Pain Relevance 0.53

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