INT3657

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Context Info
Confidence 0.78
First Reported 1976
Last Reported 2011
Negated 6
Speculated 8
Reported most in Abstract
Documents 514
Total Number 524
Disease Relevance 321.69
Pain Relevance 75.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
plasma 58
blood 28
fat 15
liver 13
muscle 13
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 1247 100.00 Very High Very High Very High
tolerance 1048 100.00 Very High Very High Very High
cytokine 440 100.00 Very High Very High Very High
Pain 237 100.00 Very High Very High Very High
allodynia 236 100.00 Very High Very High Very High
Enkephalin 85 100.00 Very High Very High Very High
Morphine 67 100.00 Very High Very High Very High
narcan 54 100.00 Very High Very High Very High
depression 30 100.00 Very High Very High Very High
Spinal cord 148 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 10151 100.00 Very High Very High Very High
Insulin Resistance 2877 100.00 Very High Very High Very High
Obesity 2554 100.00 Very High Very High Very High
INFLAMMATION 1460 100.00 Very High Very High Very High
Stress 1400 100.00 Very High Very High Very High
Pressure And Volume Under Development 1059 100.00 Very High Very High Very High
Impaired Glucose Tolerance 907 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 725 100.00 Very High Very High Very High
Apoptosis 708 100.00 Very High Very High Very High
Hyperinsulinism 487 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In these rats the administration of insulin produced a diminution in glycemia.
Gene_expression (produced) of insulin
1) Confidence 0.78 Published 1992 Journal Arch Int Physiol Biochim Biophys Section Abstract Doc Link 1282385 Disease Relevance 0.38 Pain Relevance 0.14
It is postulated that obese rats synthesize and cleave much more insulin than lean controls despite their higher circulating levels of insulin.
Gene_expression (synthesize) of insulin associated with obesity
2) Confidence 0.78 Published 1995 Journal Endocrinology Section Abstract Doc Link 7649094 Disease Relevance 0.33 Pain Relevance 0.18
Fasting levels of insulin, glucose, and triglycerides and the responses during an intravenous glucose tolerance test (IVGTT) were compared as indices of insulin resistance and the effectiveness of dietary Cr.
Gene_expression (levels) of insulin associated with tolerance, insulin resistance and impaired glucose tolerance
3) Confidence 0.77 Published 1998 Journal Metab. Clin. Exp. Section Abstract Doc Link 9550535 Disease Relevance 0.59 Pain Relevance 0.12
The sucrose solution did not affect insulin sensitivity in any group; however, urethan anesthesia did produce insulin resistance.
Gene_expression (produce) of insulin associated with anesthesia and insulin resistance
4) Confidence 0.77 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 8203621 Disease Relevance 0.41 Pain Relevance 0.26
Process in the insulin synthesis and secretion is disregulated and is related with the destruction of the ?
Gene_expression (synthesis) of insulin
5) Confidence 0.74 Published 2008 Journal Nutrition Research and Practice Section Body Doc Link PMC2788183 Disease Relevance 0.37 Pain Relevance 0
Fasting serum insulin levels were shown in Table 3.
Gene_expression (levels) of insulin
6) Confidence 0.74 Published 2008 Journal Nutrition Research and Practice Section Body Doc Link PMC2788183 Disease Relevance 1.22 Pain Relevance 0
Body weights, fasting serum glucose, and fasting serum insulin levels
Gene_expression (levels) of insulin in Body associated with body weight
7) Confidence 0.74 Published 2008 Journal Nutrition Research and Practice Section Body Doc Link PMC2788183 Disease Relevance 1.10 Pain Relevance 0
cell failure shown in diabetes could be restored by more expression of insulin receptor substrate-2 (Irs2) since Irs2 mediates replication and survival of the ?
Gene_expression (expression) of insulin associated with diabetes mellitus
8) Confidence 0.74 Published 2008 Journal Nutrition Research and Practice Section Body Doc Link PMC2788183 Disease Relevance 0.27 Pain Relevance 0
Insulin and cAMP production by islets of obese rats were both inhibited by the alpha 2-adrenoceptor agonist clonidine.
Gene_expression (production) of Insulin associated with obesity, agonist and clonidine
9) Confidence 0.74 Published 1992 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 1322330 Disease Relevance 0.33 Pain Relevance 0.35
The post-receptor biosynthetic processes involved in the expression of the biological activities of insulin (syntheses of glycogen, protein, lipid) require energy produced by oxidative metabolism while the degradation of insulin is carried out by nonlysosomal mechanisms which are not energy-requiring.
Gene_expression (expression) of insulin
10) Confidence 0.69 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3904755 Disease Relevance 0.13 Pain Relevance 0.12
The slope of the regression line for glucose disposal rate versus plasma insulin was lower in spontaneously hypertensive rats compared with Wistar-Kyoto rats (2.652 vs. 4.864, P < 0.001), indicating that insulin stimulation of glucose disposal rate was reduced by 50% in spontaneously hypertensive rats.
Gene_expression (slope) of insulin in plasma associated with hypertension
11) Confidence 0.67 Published 1993 Journal Diabetes Section Abstract Doc Link 8349047 Disease Relevance 0.64 Pain Relevance 0.06
These results indicated that nosedrops containing insulin plus an extremely low concentration (0.03%) of an absorption-enhancing agent such as tetradecylmaltoside can be used to lower blood D-glucose values.
Gene_expression (containing) of insulin in blood
12) Confidence 0.67 Published 1994 Journal Endocrinology Section Abstract Doc Link 7988421 Disease Relevance 0 Pain Relevance 0.08
The suppression was most marked in the first hour after insulin injection.
Gene_expression (injection) of insulin
13) Confidence 0.67 Published 1982 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 7051049 Disease Relevance 0.07 Pain Relevance 0.31
Does fluoxetine administration influence insulin resistance in 90% pancreatectomized rats?
Gene_expression (resistance) of insulin associated with insulin resistance and fluoxetine
14) Confidence 0.67 Published 2002 Journal Metab. Clin. Exp. Section Title Doc Link 11782870 Disease Relevance 0.34 Pain Relevance 0.64
It is postulated that obese rats synthesize and cleave much more insulin than lean controls despite their higher circulating levels of insulin.
Gene_expression (levels) of insulin associated with obesity
15) Confidence 0.67 Published 1995 Journal Endocrinology Section Abstract Doc Link 7649094 Disease Relevance 0.32 Pain Relevance 0.17
On the basis of the insulin sensitivity index, SH rats were clearly more insulin resistant than age-matched Wistar rats.
Gene_expression (resistant) of insulin associated with hypertension
16) Confidence 0.67 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 12450062 Disease Relevance 1.12 Pain Relevance 0.39
In summary, SH rats are more insulin resistant than Wistar rats, and anesthesia, which elevated basal glucose and insulin levels and increased the insulin output in response to a glucose challenge, may increase insulin resistance.
Gene_expression (resistant) of insulin associated with anesthesia, hypertension and insulin resistance
17) Confidence 0.67 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 12450062 Disease Relevance 1.11 Pain Relevance 0.37
Effects of age and anesthetic on plasma glucose and insulin levels and insulin sensitivity in spontaneously hypertensive and Wistar rats.
Gene_expression (sensitivity) of insulin in plasma associated with hypertension
18) Confidence 0.67 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 12450062 Disease Relevance 1.15 Pain Relevance 0.39
On the basis of the insulin sensitivity index, SH rats were clearly more insulin resistant than age-matched Wistar rats.
Gene_expression (resistant) of insulin associated with hypertension
19) Confidence 0.67 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 12450062 Disease Relevance 1.09 Pain Relevance 0.39
The effects of chromium (Cr) supplementation on diet-induced insulin resistance produced by feeding a high-fat, low-Cr diet were studied in rats to ascertain the role of Cr in insulin resistance.
Gene_expression (produced) of insulin in fat associated with insulin resistance
20) Confidence 0.67 Published 1998 Journal Metab. Clin. Exp. Section Abstract Doc Link 9550535 Disease Relevance 0.40 Pain Relevance 0.03

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