INT36575

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Context Info
Confidence 0.65
First Reported 1981
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 10.10
Pain Relevance 4.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFRSF10A) transcription factor binding (TNFRSF10A)
Anatomy Link Frequency
apoptotic cells 1
T cell 1
TNFRSF10A (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 13 100.00 Very High Very High Very High
Morphine 9 99.72 Very High Very High Very High
spinal inflammation 12 99.52 Very High Very High Very High
cytokine 9 95.84 Very High Very High Very High
cINOD 20 94.60 High High
palliative 1 81.12 Quite High
Inflammation 5 75.00 Quite High
Disease Link Frequency Relevance Heat
Death 24 100.00 Very High Very High Very High
Rheumatoid Arthritis 13 100.00 Very High Very High Very High
Disease 3 99.98 Very High Very High Very High
Apoptosis 34 99.90 Very High Very High Very High
Low Back Pain 12 99.52 Very High Very High Very High
Membranous Glomerulonephritis 3 98.96 Very High Very High Very High
Systemic Sclerosis 4 97.84 Very High Very High Very High
Dermatomyositis 3 96.88 Very High Very High Very High
Systemic Lupus Erythematosus 5 96.84 Very High Very High Very High
Stomach Cancer 15 93.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HLA typing revealed the presence of HLA A2, A9, B8, B27, DR3 and DR4 antigens.
Gene_expression (presence) of DR4
1) Confidence 0.65 Published 1988 Journal Br. J. Rheumatol. Section Abstract Doc Link 3365534 Disease Relevance 0.78 Pain Relevance 0.40
Concurrent presence of the HLA-B27 and HLA-DR4 antigens was demonstrated.
Gene_expression (presence) of DR4
2) Confidence 0.65 Published 1981 Journal J. Rheumatol. Section Abstract Doc Link 6975378 Disease Relevance 0.71 Pain Relevance 0.59
Much of the genetic contribution to these diseases lies in the MHC, including HLA-DR4 (RA), HLA-B27 (AS), HLA-DRB1*0301, DRB1*1501/*1503, DRB1*08, and C4 null alleles (SLE), and HLA-DRB1*11 and DRB1*1502 (SSc).
Gene_expression (lies) of RA associated with spinal inflammation, rheumatoid arthritis, systemic sclerosis, systemic lupus erythematosus and disease
3) Confidence 0.65 Published 2005 Journal J Rheumatol Suppl Section Abstract Doc Link 15660456 Disease Relevance 1.94 Pain Relevance 0.66
NAG-1 cDNA was transfected into SNU601 cells, and the relation between the ectopic expression of NAG-1 and death receptor-4 (DR-4) and DR-5 levels was studied.
Gene_expression (expression) of death receptor-4 associated with death
4) Confidence 0.07 Published 2004 Journal Carcinogenesis Section Abstract Doc Link 15180942 Disease Relevance 1.07 Pain Relevance 0.38
NAG-1 cDNA was transfected into SNU601 cells, and the relation between the ectopic expression of NAG-1 and death receptor-4 (DR-4) and DR-5 levels was studied.
Gene_expression (expression) of DR-4 associated with death
5) Confidence 0.07 Published 2004 Journal Carcinogenesis Section Abstract Doc Link 15180942 Disease Relevance 1.07 Pain Relevance 0.38
Moreover, temporal expressions of DR-4 and DR-5 induced by sulindac sulfide were similar to that of NAG-1.
Gene_expression (expressions) of DR-4
6) Confidence 0.06 Published 2004 Journal Carcinogenesis Section Abstract Doc Link 15180942 Disease Relevance 1.03 Pain Relevance 0.33
NAG-1 cDNA was transfected into SNU601 cells, and the relation between the ectopic expression of NAG-1 and death receptor-4 (DR-4) and DR-5 levels was studied.
Gene_expression (levels) of DR-4 associated with death
7) Confidence 0.06 Published 2004 Journal Carcinogenesis Section Abstract Doc Link 15180942 Disease Relevance 1.07 Pain Relevance 0.37
Forced NAG-1 expression significantly induced apoptosis and DR-4 and DR-5 expression.
Gene_expression (expression) of DR-4 associated with apoptosis
8) Confidence 0.05 Published 2004 Journal Carcinogenesis Section Abstract Doc Link 15180942 Disease Relevance 0.97 Pain Relevance 0.29
Death of the Bcl-2 overexpressing B cells can be explained by the prominent induction of the extrinsic apoptotic pathway, with an active role of the neoplastic microenvironment for the expression of death receptor ligands and the clearance of the apoptotic cells.
Gene_expression (expression) of death receptor in apoptotic cells associated with apoptosis and death
9) Confidence 0.03 Published 2008 Journal Cell Cycle Section Abstract Doc Link 18235230 Disease Relevance 0.81 Pain Relevance 0.08
We previously showed that morphine enhances Fas death receptor expression in a T cell hybridoma and human PBL.
Gene_expression (expression) of death receptor in T cell associated with death and morphine
10) Confidence 0.02 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16210602 Disease Relevance 0.65 Pain Relevance 0.70

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