INT3658

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Context Info
Confidence 0.53
First Reported 1976
Last Reported 2010
Negated 8
Speculated 3
Reported most in Abstract
Documents 28
Total Number 32
Disease Relevance 12.89
Pain Relevance 8.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gcg) extracellular region (Gcg) cytoplasm (Gcg)
Anatomy Link Frequency
plasma 5
blood 2
neuronal 1
liver 1
pancreas 1
Gcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 30 100.00 Very High Very High Very High
substance P 7 100.00 Very High Very High Very High
Opioid 4 100.00 Very High Very High Very High
anesthesia 18 99.92 Very High Very High Very High
Chronic pancreatitis 10 99.84 Very High Very High Very High
Morphine 28 99.82 Very High Very High Very High
tetrodotoxin 12 99.58 Very High Very High Very High
Clonidine 17 99.20 Very High Very High Very High
tolerance 33 99.04 Very High Very High Very High
antagonist 5 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Appetite Loss 516 99.84 Very High Very High Very High
Pancreatitis 12 99.84 Very High Very High Very High
Hypoglycemia 10 99.84 Very High Very High Very High
Iron Overload 7 99.40 Very High Very High Very High
Decapitation 5 99.32 Very High Very High Very High
Hyperinsulinism 8 99.16 Very High Very High Very High
Impaired Glucose Tolerance 46 99.04 Very High Very High Very High
Cancer 6 98.80 Very High Very High Very High
Diabetes Mellitus 195 98.12 Very High Very High Very High
Hyperglycemia 31 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of pinealectomy on plasma glucose, insulin and glucagon levels in the rat.
Regulation (Effect) of glucagon in plasma
1) Confidence 0.53 Published 1986 Journal Horm. Metab. Res. Section Title Doc Link 3519410 Disease Relevance 0 Pain Relevance 0.07
Comparison of the modifying effects of somatostatin and propranolol on morphine-induced changes in glucose, glucagon and insulin levels in fed rats.
Regulation (changes) of glucagon associated with somatostatin and morphine
2) Confidence 0.53 Published 1993 Journal Life Sci. Section Title Doc Link 8102765 Disease Relevance 0 Pain Relevance 0.74
Somatic afferent regulation of plasma immunoreactive glucagon in anesthetized rats.
Regulation (regulation) of glucagon in plasma associated with anesthesia
3) Confidence 0.52 Published 1994 Journal Jpn. J. Physiol. Section Title Doc Link 7823413 Disease Relevance 0 Pain Relevance 0.10
The effects of the fentanyl fluanisone combination (Hypnorm) and pentobarbitone sodium (Pentobarbital) anaesthesia on blood glucose, insulin and glucagon were tested in rats in the fed and fasted state.
Regulation (effects) of glucagon in blood
4) Confidence 0.48 Published 1994 Journal Lab. Anim. Section Abstract Doc Link 7967463 Disease Relevance 0.05 Pain Relevance 0.03
Therefore the influences of the procedure on the plasma insulin, glucagon and glucose responses were studied in healthy rats and in rats with a tumour inoculated subcapsularly into the liver.
Regulation (responses) of glucagon in liver associated with cancer
5) Confidence 0.46 Published 1990 Journal Br J Surg Section Abstract Doc Link 2187562 Disease Relevance 0.33 Pain Relevance 0.09
We examined the effect of intravenous injection of the amphibian skin opioid heptapeptide dermorphin on plasma glucose, insulin, glucagon and somatostatin in the rat.
Spec (examined) Regulation (effect) of glucagon in skin associated with somatostatin and opioid
6) Confidence 0.38 Published 1983 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6141770 Disease Relevance 0 Pain Relevance 0.35
Considering the vast physiological actions promoted by the incretins, not only related with the control of glucose by insulin and glucagon regulation, but also with the peripheral insulin sensitization, cardiac and neuronal protection and beta-cell preservation, the use of an incretin enhancer (such as sitagliptin) might present beneficial effects on diabetes pathophysiology and on prevention of its serious complications, which deserves better elucidation.
Regulation (regulation) of glucagon in neuronal associated with diabetes mellitus
7) Confidence 0.35 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2905949 Disease Relevance 0.78 Pain Relevance 0.04
Non-adrenergic non-cholinergic effects do not participate in regulation of glucagon and somatostatin secretion under the conditions employed.
Regulation (regulation) of glucagon associated with somatostatin
8) Confidence 0.32 Published 1992 Journal Diabetologia Section Abstract Doc Link 1478364 Disease Relevance 0 Pain Relevance 0.31
The somatostatin response was attenuated by tetrodotoxin while the change of glucagon remained unaffected.
Neg (unaffected) Regulation (unaffected) of glucagon associated with tetrodotoxin and somatostatin
9) Confidence 0.32 Published 1992 Journal Diabetologia Section Abstract Doc Link 1478364 Disease Relevance 0.09 Pain Relevance 0.49
Only glucagon levels changed significantly during induction and maintenance of hyperglycemia.
Regulation (changed) of glucagon associated with hyperglycemia
10) Confidence 0.32 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16280413 Disease Relevance 0.78 Pain Relevance 0.17
KX-induced changes of glucoregulatory hormone levels such as insulin, GH, ACTH, and corticosterone were significantly altered by yohimbine, whereas the glucagon levels remained unaffected.
Neg (unaffected) Regulation (unaffected) of glucagon
11) Confidence 0.31 Published 2005 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 16246906 Disease Relevance 0.66 Pain Relevance 0.31
At the time intervals sampled, radioimmunoassayable plasma levels of growth hormone, glucagon, and insulin were not significantly changed after injection of NT into normal rats.
Neg (not) Regulation (changed) of glucagon in plasma
12) Confidence 0.29 Published 1976 Journal Endocrinology Section Abstract Doc Link 826391 Disease Relevance 0.31 Pain Relevance 0.09
The enhanced glucagon response to arginine and the nonsuppressibility of glucagon secretion by oral glucose found in these patients were similar to the results found in the same tests performed in our previous series of patients with "idiopathic" diabetes and at variance with those reported by others in patients with chronic pancreatitis.
Regulation (response) of glucagon associated with diabetes mellitus and chronic pancreatitis
13) Confidence 0.26 Published 1977 Journal Diabetologia Section Abstract Doc Link 908475 Disease Relevance 0.80 Pain Relevance 0.09
At variance with the modest effects of glucagon, D-glucose, L-arginine, or a tumor-promoting phorbol ester upon cyclic AMP production by intact islets, forskolin caused a six-fold increase in cyclic AMP production.
Regulation (effects) of glucagon associated with cancer
14) Confidence 0.26 Published 1984 Journal Biosci. Rep. Section Abstract Doc Link 6087950 Disease Relevance 0.10 Pain Relevance 0.69
Since both glucose and glucagon effects were influenced by the addition of clonidine, it is possible to interpret the data as indicating that the effects of both stimulators eventually converge at some common step in the adenylate cyclase cascade.
Regulation (influenced) of glucagon associated with clonidine
15) Confidence 0.26 Published 1990 Journal Second Messengers Phosphoproteins Section Abstract Doc Link 1962819 Disease Relevance 0 Pain Relevance 0.36
Future studies from us will estimate the effects of this DPP-IV inhibitor on the enzyme activity/expression, as well as on levels of GLP-1 and glucagon, in order to have a more detailed picture of how the incretins pathway is affected and its relative contribution for the effects of sitagliptin here reported.
Regulation (effects) of glucagon
16) Confidence 0.26 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2905949 Disease Relevance 1.06 Pain Relevance 0
Our present data show that early malnutrition does not exert any affect on glucagon values however; post-weaning malnutrition decreases the glucagon levels for more than 50% compared to controls, even after short and long term nutritional rehabilitation.
Neg (not) Regulation (affect) of glucagon associated with appetite loss
17) Confidence 0.25 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2586678 Disease Relevance 1.13 Pain Relevance 0
Glucagon receptors were however, affected by dietary carbohydrates.
Regulation (affected) of Glucagon
18) Confidence 0.24 Published 1992 Journal Life Sci. Section Abstract Doc Link 1579053 Disease Relevance 0.34 Pain Relevance 0.43
In contrast the combined adrenergic and cholinergic blockade with atropine, phentolamine and propranolol (10(-5) mol/l) did not modify the insulin, glucagon and somatostatin response.
Neg (not) Regulation (response) of glucagon associated with somatostatin
19) Confidence 0.19 Published 1992 Journal Diabetologia Section Abstract Doc Link 1478364 Disease Relevance 0.08 Pain Relevance 0.56
Subsequent bilateral electrical cervical vagal stimulation-induced insulin and glucagon responses in the same animals under anesthesia showed the same branch dependency.
Regulation (responses) of glucagon associated with anesthesia
20) Confidence 0.19 Published 1990 Journal Am. J. Physiol. Section Abstract Doc Link 2178454 Disease Relevance 0 Pain Relevance 0.10

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