INT36580

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Context Info
Confidence 0.45
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.63
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (LCN1)
Anatomy Link Frequency
plasma 1
testis 1
peripheral nerves 1
LCN 1
LCN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 69 96.80 Very High Very High Very High
cytokine 49 94.64 High High
Spinal cord 2 93.76 High High
Thalamus 2 90.16 High High
Inflammatory response 31 89.52 High High
beta blocker 7 88.48 High High
Inflammatory marker 3 85.80 High High
medulla 4 77.20 Quite High
wide dynamic range 8 47.12 Quite Low
chemokine 7 43.80 Quite Low
Disease Link Frequency Relevance Heat
Severe Acute Respiratory Syndrome 144 100.00 Very High Very High Very High
Influenza Virus Infection 21 99.68 Very High Very High Very High
Chronic Renal Failure 20 98.88 Very High Very High Very High
Embryonal Carcinoma 6 97.32 Very High Very High Very High
Death 25 96.84 Very High Very High Very High
INFLAMMATION 106 96.80 Very High Very High Very High
Stress 3 95.92 Very High Very High Very High
Cv General 2 Under Development 7 94.88 High High
Renal Disease 52 92.12 High High
Vasculitis 1 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among genes induced in larvae by copper exposure, we detected strong stimulation of the mmp9 gene (VEG, OAP and MLA, unpublished work).
Positive_regulation (stimulation) of VEG
1) Confidence 0.45 Published 2010 Journal BMC Biol Section Body Doc Link PMC3022775 Disease Relevance 0.56 Pain Relevance 0.11
This locus represents a fusion of two GenomeScan-predicted models, LCN6 and an adjacent lipocalin-like gene based on BG256703, a bridging EST derived from a testis embryonal carcinoma cell line.
Positive_regulation (adjacent) of lipocalin in testis associated with embryonal carcinoma
2) Confidence 0.38 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0.10 Pain Relevance 0
Most of the ESTs listed from this combined locus are derived from the 3' lipocalin-like adjacent gene.
Positive_regulation (derived) of lipocalin
3) Confidence 0.38 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293424 Disease Relevance 0.09 Pain Relevance 0.04
We confirmed our microarrays findings by Real time PCR on selected upregulated genes such as Lactoferrin Lipocalin, S100P, FCGR3A, and TLR2 (Figure 2).
Positive_regulation (upregulated) of Lipocalin
4) Confidence 0.05 Published 2005 Journal BMC Immunol Section Body Doc Link PMC546205 Disease Relevance 0.29 Pain Relevance 0.13
and IL-12-p40 were upregulated, whereas genes upregulated in the SARS patients (LTF, Lipocalin, S100P, FGR3A and TLR2), were not upregulated in the influenza patients.
Neg (not) Positive_regulation (upregulated) of Lipocalin associated with influenza virus infection and severe acute respiratory syndrome
5) Confidence 0.04 Published 2005 Journal BMC Immunol Section Body Doc Link PMC546205 Disease Relevance 1.05 Pain Relevance 0.16
and IL-12-p40 were upregulated, whereas genes upregulated in the SARS patients (LTF, Lipocalin, S100P, FGR3A and TLR2), were not upregulated in the influenza patients.
Positive_regulation (upregulated) of Lipocalin associated with influenza virus infection and severe acute respiratory syndrome
6) Confidence 0.04 Published 2005 Journal BMC Immunol Section Body Doc Link PMC546205 Disease Relevance 1.03 Pain Relevance 0.16
Individuals with CKD become progressively malnourished, as evidenced by low levels of albumin, prealbumin, and transferrin, which has been suggested to be a mechanism for activation of inflammation.24,25 Renal failure causes changes in plasma components and endothelial structure and function, thereby favoring vascular injury, which may play a role as a trigger for inflammatory response.26-28 Between 30 and 50% of CKD patients have elevated serum levels of inflammatory markers such as C-reactive protein, interleukin-6, and tumor necrosis factor-?.
Positive_regulation (levels) of prealbumin in plasma associated with necrosis, inflammatory response, chronic renal failure, inflammation, cancer, inflammatory marker and vasculitis
7) Confidence 0.04 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730617 Disease Relevance 2.44 Pain Relevance 0.25
Mean latency for orthodromic activation of LCN neurons following electrical stimulation of peripheral nerves was 12.6 ms.
Positive_regulation (activation) of LCN in peripheral nerves
8) Confidence 0.01 Published 1988 Journal J. Neurophysiol. Section Abstract Doc Link 3367201 Disease Relevance 0 Pain Relevance 0.09
Latencies for antidromic activation of LCN neurons averaged 2.3 ms, corresponding to a mean conduction velocity of approximately 17 m/s.
Positive_regulation (activation) of LCN in LCN
9) Confidence 0.01 Published 1988 Journal J. Neurophysiol. Section Abstract Doc Link 3367201 Disease Relevance 0 Pain Relevance 0.09

General Comments

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