INT36581

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Context Info
Confidence 0.48
First Reported 1986
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.47
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Orm1) extracellular space (Orm1) extracellular region (Orm1)
Anatomy Link Frequency
plasma 2
Orm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endep 2 99.62 Very High Very High Very High
methadone 8 99.52 Very High Very High Very High
lidocaine 4 99.40 Very High Very High Very High
Dorsal horn 7 92.72 High High
Spinal cord 5 92.08 High High
qutenza 3 90.80 High High
Nortriptyline 1 86.60 High High
Desipramine 1 85.52 High High
analgesia 2 84.24 Quite High
Analgesic 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Burns 4 94.40 High High
Injury 1 77.92 Quite High
INFLAMMATION 5 65.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Methadone is a basic drug highly bound to alpha1-acid glycoprotein (AGP), a plasma protein that increases in several pathological situations.
AGP Binding (bound) of in plasma associated with methadone
1) Confidence 0.48 Published 2004 Journal J Pharm Sci Section Abstract Doc Link 15452846 Disease Relevance 0.07 Pain Relevance 0.58
CONCLUSION: Resistance to atracurium during corynebacterium parvum-induced systemic inflammation is due to increased drug binding to alpha1 -acid glycoprotein and is unrelated to changes in acetylcholine receptor expression.


acid glycoprotein Binding (binding) of
2) Confidence 0.41 Published 2003 Journal Anesthesiology Section Body Doc Link 12502983 Disease Relevance 0 Pain Relevance 0
Selectivity in the binding of psychotropic drugs to the variants of alpha-1 acid glycoprotein.
alpha-1 acid glycoprotein Binding (binding) of associated with endep
3) Confidence 0.36 Published 1988 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 3368020 Disease Relevance 0 Pain Relevance 0.34
The high nonspecific [3H]RTX binding of the original protocol was reduced by the addition of alpha 1-acid glycoprotein (AGP), a plasma protein that binds RTX, to the assay mixture after the binding reaction had been terminated.
AGP Binding (binds) of in plasma
4) Confidence 0.35 Published 1994 Journal Life Sci. Section Abstract Doc Link 8035647 Disease Relevance 0 Pain Relevance 0.47
Imipramine, lidocaine, meperidine, and propranolol bind primarily to alpha-1 acid glycoprotein.
alpha-1 acid glycoprotein Binding (bind) of associated with lidocaine
5) Confidence 0.10 Published 1986 Journal J Clin Pharmacol Section Abstract Doc Link 3950058 Disease Relevance 0.41 Pain Relevance 0.33
CONCLUSIONS: The disposition of the active enantiomer, R -methadone, can be predicted in part by CYP3A activity and protein binding to alpha1-AGP (ORM2), whereas S-methadone disposition is not well explained by the factors examined in this study.
alpha1-AGP Binding (binding) of
6) Confidence 0.00 Published 2001 Journal Clin. Pharmacol. Ther. Section Body Doc Link 11452244 Disease Relevance 0 Pain Relevance 0

General Comments

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