INT36584

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Context Info
Confidence 0.32
First Reported 1988
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.11
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grpr) signal transducer activity (Grpr)
Anatomy Link Frequency
lateral spinal nucleus 1
Grpr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 1 100.00 Very High Very High Very High
substance P 2 99.92 Very High Very High Very High
Potency 1 99.92 Very High Very High Very High
Dynorphin 2 99.32 Very High Very High Very High
Neuropeptide 6 96.80 Very High Very High Very High
agonist 3 90.64 High High
Enkephalin 1 85.36 High High
Cholecystokinin 1 84.32 Quite High
Somatostatin 2 82.64 Quite High
spinothalamic 1 75.04 Quite High
Disease Link Frequency Relevance Heat
Pain 1 59.80 Quite High
Adhesions 1 50.12 Quite High
Dysmenorrhea 1 5.00 Very Low Very Low Very Low
Bordatella Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two specific GRP-preferring receptor antagonists, namely [D-Phe6]Bn-(6-13) methyl ester and [Leu14,psi 13-14]Bn were inhibitory for both Bn-mediated tension and generation of inositol phosphates. [125I-Tyr4]Bn bound to myometrial membranes with high affinity (Kd = 104 pM) to a single class of sites in a saturable and reversible manner.
GRP-preferring receptor Binding (bound) of associated with antagonist
1) Confidence 0.32 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8279518 Disease Relevance 0 Pain Relevance 0.10
In conclusion, we show that for the PLC-coupled GRP-R, receptor number had little or no effect on binding affinity, potency for activating PLC, tyrosine phosphorylation of p125FAK, or extent of receptor internalization.
GRP-R Binding (affinity) of associated with potency
2) Confidence 0.19 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9145910 Disease Relevance 0.05 Pain Relevance 0.14
The lateral spinal nucleus had the highest percentage of neuropeptide containing ascending tract cells; cells of all the four populations of peptidergic neurons lying in this region were involved in supraspinal projections; they stained for vasoactive intestinal polypeptide, bombesin, substance P or dynorphin and their axons projected in the spinomesencephalic, spinoreticular and spinosolitary tracts.
bombesin Binding (stained) of in lateral spinal nucleus associated with dynorphin, neuropeptide and substance p
3) Confidence 0.17 Published 1988 Journal Neuroscience Section Abstract Doc Link 3368049 Disease Relevance 0.06 Pain Relevance 0.66

General Comments

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