INT36588

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Context Info
Confidence 0.87
First Reported 1984
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.98
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
cleavage 1
neural 1
mast cells 1
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 19 100.00 Very High Very High Very High
metalloproteinase 16 99.74 Very High Very High Very High
Rsd 2 99.60 Very High Very High Very High
qutenza 6 99.08 Very High Very High Very High
Chronic pancreatitis 2 92.56 High High
Analgesic 1 91.20 High High
tolerance 19 90.72 High High
backache 1 88.08 High High
substance P 4 50.00 Quite Low
Potency 1 45.20 Quite Low
Disease Link Frequency Relevance Heat
Natriuresis 5 100.00 Very High Very High Very High
Osteoporosis 2 100.00 Very High Very High Very High
Reflex Sympathetic Dystrophy 2 99.60 Very High Very High Very High
Increased Venous Pressure Under Development 7 98.76 Very High Very High Very High
Disease 3 98.52 Very High Very High Very High
Weight Gain 9 93.12 High High
Pancreatitis 2 92.56 High High
Impaired Glucose Tolerance 20 92.08 High High
Hyperglycemia 3 88.80 High High
Hyperlipidemia 2 88.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Calcitonin treatment for osteoporosis].
Protein_catabolism (osteoporosis) of Calcitonin associated with osteoporosis
1) Confidence 0.87 Published 2001 Journal Clin Calcium Section Title Doc Link 15775633 Disease Relevance 0.20 Pain Relevance 0.18
Local intradermal calcitonin].
Protein_catabolism (intradermal) of calcitonin
2) Confidence 0.75 Published 1984 Journal Chir Ital Section Title Doc Link 6545144 Disease Relevance 0.20 Pain Relevance 0.20
CONCLUSIONS: These data suggest that SP participates in regulation of gastric mucosal blood flow by activation of mast cells most likely by releasing proteases from mast cells that cleave and inactivate CGRP.


Protein_catabolism (cleave) of CGRP in mast cells
3) Confidence 0.56 Published 1994 Journal Gastroenterology Section Body Doc Link 7507874 Disease Relevance 0.06 Pain Relevance 0
The concentration of calcitonin was considerably raised, the most noticeable elevation was observed in patients with a severe course.
Protein_catabolism (concentration) of calcitonin
4) Confidence 0.40 Published 1988 Journal Ter. Arkh. Section Abstract Doc Link 3368866 Disease Relevance 0.27 Pain Relevance 0.17
In these studies, we propose that AVE7688, Candoxatril, and to a lesser extent Enalapril may be protecting vascular reactivity and neural function by inhibiting neutral endopeptidase and the degradation of C-type natriuretic peptide and calcitonin gene-related peptide [11–13, 20].

5.

Protein_catabolism (degradation) of calcitonin in neural associated with natriuresis and calcitonin gene-related peptide
5) Confidence 0.32 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2933895 Disease Relevance 1.16 Pain Relevance 0.10
Carbopol polymers have been shown to inhibit luminal degradation of insulin, calcitonin, and insulin-like growth factor-I (IGF-I) by trypsin and chymotrypsin61.
Protein_catabolism (degradation) of calcitonin
6) Confidence 0.13 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792531 Disease Relevance 0 Pain Relevance 0
Vascular matrix metalloproteinase-2-dependent cleavage of calcitonin gene-related peptide promotes vasoconstriction.
Protein_catabolism (cleavage) of calcitonin in cleavage associated with qutenza, metalloproteinase, increased venous pressure under development and calcitonin gene-related peptide
7) Confidence 0.08 Published 2000 Journal Circ. Res. Section Title Doc Link 11029402 Disease Relevance 0.10 Pain Relevance 0.67

General Comments

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