INT3659

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Context Info
Confidence 0.51
First Reported 1976
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 26
Total Number 27
Disease Relevance 10.08
Pain Relevance 7.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gcg) extracellular region (Gcg) cytoplasm (Gcg)
Anatomy Link Frequency
plasma 4
blood 2
intermediary 1
nephron 1
urine 1
Gcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 4 100.00 Very High Very High Very High
Cholecystokinin 2 100.00 Very High Very High Very High
qutenza 22 99.84 Very High Very High Very High
anesthesia 11 99.84 Very High Very High Very High
narcan 8 99.72 Very High Very High Very High
Chronic pancreatitis 7 99.38 Very High Very High Very High
Clonidine 4 99.32 Very High Very High Very High
Somatostatin 20 99.24 Very High Very High Very High
Morphine 18 99.20 Very High Very High Very High
agonist 12 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 4 100.00 Very High Very High Very High
Appetite Loss 387 99.98 Very High Very High Very High
Pancreatitis 8 99.38 Very High Very High Very High
Diabetes Mellitus 105 98.70 Very High Very High Very High
Gastric Motility Disorder 2 97.92 Very High Very High Very High
Impaired Glucose Tolerance 29 97.46 Very High Very High Very High
Hyperglycemia 20 95.52 Very High Very High Very High
Hypertension 7 95.20 Very High Very High Very High
Hypoglycemia 14 95.04 Very High Very High Very High
Hyperlipidemia 10 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The combined reduction of both glucagon and glucose after somatostatin or propranolol treatment in morphine exposed rats, points to glucagon as a potential link between opioid stimulation and hyperglycemia.
Negative_regulation (reduction) of glucagon associated with hyperglycemia, somatostatin, opioid and morphine
1) Confidence 0.51 Published 1993 Journal Life Sci. Section Abstract Doc Link 8102765 Disease Relevance 0.09 Pain Relevance 1.09
The fed rats given Pentobarbital, had unchanged blood glucose, a slight non-significant depression of glucagon and a significant increase in insulin (P < 0.01).
Negative_regulation (depression) of glucagon in blood associated with depression
2) Confidence 0.45 Published 1994 Journal Lab. Anim. Section Abstract Doc Link 7967463 Disease Relevance 0.19 Pain Relevance 0.09
Capsaicin and its effects upon meal patterns, and glucagon and epinephrine suppression of food intake.
Negative_regulation (suppression) of glucagon associated with qutenza
3) Confidence 0.43 Published 1987 Journal Physiol. Behav. Section Title Doc Link 3659150 Disease Relevance 0.08 Pain Relevance 0.84
The secretory responsiveness to glucose plus glucagon was completely suppressed by 10(-7) mol/l clonidine.
Negative_regulation (suppressed) of glucagon associated with clonidine
4) Confidence 0.41 Published 1990 Journal Diabetologia Section Abstract Doc Link 2076797 Disease Relevance 0 Pain Relevance 0.10
Fentanyl plus pentobarbital, anesthesia caused reductions of insulin and glucagon levels in the plasma and a decrease in catecholamines excretion in the urine.
Negative_regulation (reductions) of glucagon in urine associated with anesthesia and catecholamine
5) Confidence 0.38 Published 1996 Journal J. Surg. Res. Section Abstract Doc Link 8656639 Disease Relevance 0.52 Pain Relevance 0.56
Furthermore, glucagon and the sympatho-adrenal system increase and decrease, respectively, the plasma insulin concentration.
Negative_regulation (decrease) of glucagon in plasma
6) Confidence 0.37 Published 1981 Journal Horm. Metab. Res. Section Abstract Doc Link 7021387 Disease Relevance 0.07 Pain Relevance 0.06
Adrenal corticosterone and pancreatic glucagon responses were not impaired.
Negative_regulation (impaired) of glucagon
7) Confidence 0.37 Published 2003 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12388440 Disease Relevance 0.57 Pain Relevance 0.20
Tetracaine inhibited the adenylate cyclase activity in the order glucagon greater than basal greater than fluoride; it seems that tetracaine acted at the receptor unit level since it reduced the binding affinity.
Negative_regulation (inhibited) of glucagon
8) Confidence 0.37 Published 1983 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6309252 Disease Relevance 0 Pain Relevance 0.08
There was a remarkable glucagon decrease after naloxone and morphine remaining from 5 to 25 min.
Negative_regulation (decrease) of glucagon associated with narcan and morphine
9) Confidence 0.35 Published 1992 Journal Life Sci. Section Abstract Doc Link 1528092 Disease Relevance 0.08 Pain Relevance 0.97
The fasted rats given Pentobarbital had unchanged blood glucose and plasma insulin and a non-significant depression of glucagon.
Negative_regulation (depression) of glucagon in blood associated with depression
10) Confidence 0.33 Published 1994 Journal Lab. Anim. Section Abstract Doc Link 7967463 Disease Relevance 0.17 Pain Relevance 0.09
Plasma glucagon, corticosterone, epinephrine and norepinephrine levels were reduced in CAP-rats: 43 +/- 2 compared with 70 +/- 6 pg/ml, 855 +/- 55 compared with 1131 +/- 138 nmol/l, 513 +/- 136 compared with 1048 +/- 164 pmol/l and 928 +/- 142 compared with 1472 +/- 331 pmol/l, respectively, p < 0.05.
Negative_regulation (reduced) of glucagon in Plasma associated with qutenza
11) Confidence 0.32 Published 1998 Journal Diabetologia Section Abstract Doc Link 9686923 Disease Relevance 0.23 Pain Relevance 0.85
KX-induced changes of glucoregulatory hormone levels such as insulin, GH, ACTH, and corticosterone were significantly altered by yohimbine, whereas the glucagon levels remained unaffected.
Neg (unaffected) Negative_regulation (unaffected) of glucagon
12) Confidence 0.30 Published 2005 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 16246906 Disease Relevance 0.66 Pain Relevance 0.31
Activation of liver glycogen phosphorylase did not occur in vitro under conditions found suitable for demonstrating the effectiveness of glucagon, suggesting the possible involvement of an intermediary substanc(s) in vivo.
Negative_regulation (effectiveness) of glucagon in intermediary
13) Confidence 0.27 Published 1976 Journal Endocrinology Section Abstract Doc Link 826391 Disease Relevance 0.36 Pain Relevance 0
Future studies from us will estimate the effects of this DPP-IV inhibitor on the enzyme activity/expression, as well as on levels of GLP-1 and glucagon, in order to have a more detailed picture of how the incretins pathway is affected and its relative contribution for the effects of sitagliptin here reported.
Negative_regulation (inhibitor) of glucagon
14) Confidence 0.25 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2905949 Disease Relevance 1.00 Pain Relevance 0
Our present data show that early malnutrition does not exert any affect on glucagon values however; post-weaning malnutrition decreases the glucagon levels for more than 50% compared to controls, even after short and long term nutritional rehabilitation.
Negative_regulation (decreases) of glucagon associated with appetite loss
15) Confidence 0.24 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2586678 Disease Relevance 1.11 Pain Relevance 0
At 90 days, after balanced diet rehabilitation, the MGL group showed a similar glucose tolerance test as the controls but display low values of insulin, while the MPW group exhibited high levels of glucose and TAG, and low values of insulin, glucagon, FFA and hepatic glycogen.
Negative_regulation (values) of glucagon associated with tolerance and impaired glucose tolerance
16) Confidence 0.24 Published 2008 Journal International Journal of Biological Sciences Section Abstract Doc Link PMC2586678 Disease Relevance 0.91 Pain Relevance 0.13
Secretin, a structurally related peptide, was also active at higher concentrations whereas another partial analogue, glucagon, was ineffective.
Negative_regulation (ineffective) of glucagon
17) Confidence 0.22 Published 1980 Journal Neuroendocrinology Section Abstract Doc Link 7413020 Disease Relevance 0 Pain Relevance 0.21
In conclusion, glucose counterregulation is preserved but slightly impaired in patients with diabetes secondary to chronic pancreatitis, and the combination of total glucagon deficiency and pharmacological blockade of the metabolic actions of circulating epinephrine abolishes glucose counterregulation after hypoglycemia.
Negative_regulation (deficiency) of glucagon associated with hypoglycemia, diabetes mellitus and chronic pancreatitis
18) Confidence 0.21 Published 1990 Journal Metab. Clin. Exp. Section Abstract Doc Link 1967815 Disease Relevance 1.06 Pain Relevance 0.41
However, in the MPW group glucagon was significantly decreased at 55 days and was not restored after nutritional rehabilitation at 90 and 180 days (fig. 5 D, E, F).
Negative_regulation (decreased) of glucagon associated with appetite loss
19) Confidence 0.21 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2586678 Disease Relevance 1.79 Pain Relevance 0
Secretin, a structurally related peptide, was also active at higher concentrations, whereas another partial analogue, glucagon, was ineffective.
Negative_regulation (ineffective) of glucagon
20) Confidence 0.20 Published 1981 Journal J. Physiol. (Paris) Section Abstract Doc Link 6122734 Disease Relevance 0 Pain Relevance 0.17

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