INT36616

Context Info Confidence 0.67 First Reported 1972 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 8 Disease Relevance 3.00 Pain Relevance 2.07

transport (ALB) small molecule metabolic process (ALB) enzyme binding (ALB) DNA binding (ALB) protein complex (ALB) transmembrane transport (ALB)

Anatomy Link Frequency blood 2 nasal 2 ALB (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 4 100.00 methadone 4 100.00 Dynorphin 2 100.00 ischemia 11 99.42 cva 15 99.28 Opioid 2 98.90 Arthritis 54 91.84 postherpetic neuralgia 2 84.08 Analgesic 1 75.00 anesthesia 2 68.00

Disease Link Frequency Relevance Heat INFLAMMATION 39 100.00 Cv Unclassified Under Development 9 99.42 Angina 7 99.28 Emergencies 5 99.00 Cv General 4 Under Development 7 94.72 Arthritis 56 91.84 Myocardial Infarction 46 90.96 Pressure And Volume Under Development 4 90.12 Acquired Immune Deficiency Syndrome Or Hiv Infection 8 87.52 Pulmonary Embolism 10 86.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The accumulation of a tripartite complex of TM, copper, and albumin turns over slowly.

Positive_regulation (accumulation) of albumin Binding (complex) of

1) Confidence 0.67 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297562 Disease Relevance 0.99 Pain Relevance 0.29

Structural requirements for binding of nonsteroidal anti-inflammatory drugs to human serum albumin.

Positive_regulation (requirements) of serum albumin Binding (binding) of associated with inflammation and cinod

2) Confidence 0.48 Published 1988 Journal J Pharm Sci Section Title Doc Link 3373430 Disease Relevance 0.20 Pain Relevance 0.29

The percent of methadone bound to albumin was relatively independent of the concentration of methadone, but was dependent on the concentration of albumin, ranging from 8.0 to 43.8 percent bound as the albumin concentration increased from 0.400 gram to 5.00 grams per 100 milliliters of solution.

Positive_regulation (dependent) of albumin Binding (bound) of associated with methadone

3) Confidence 0.47 Published 1972 Journal Science Section Abstract Doc Link 5032355 Disease Relevance 0 Pain Relevance 0.37

When the concentration of albumin was increased to 40?

Positive_regulation (increased) of albumin Binding (concentration) of

4) Confidence 0.44 Published 2009 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2778444 Disease Relevance 0.09 Pain Relevance 0

How do fatty acids cause allosteric binding of drugs to human serum albumin?

Positive_regulation (cause) of serum albumin Binding (binding) of

5) Confidence 0.43 Published 2002 Journal Pharm. Res. Section Title Doc Link 12425462 Disease Relevance 0 Pain Relevance 0.09

INTRODUCTION: CJC-1008 is a chemical modification of the opioid peptide dynorphin A (1-13) (Dyn A) that promotes dynorphin's covalent attachment to human serum albumin in vivo after administration, thus prolonging its duration of action.

Positive_regulation (promotes) of albumin Binding (attachment) of associated with dynorphin and opioid

6) Confidence 0.35 Published 2006 Journal J Opioid Manag Section Abstract Doc Link 17319450 Disease Relevance 0.07 Pain Relevance 0.51

CONCLUSIONS: We conclude that non-allergic rhinitis is not characterized by increased responsiveness of capsaicin-sensitive nerve fibres; while allergic rhinitis is marked by hyperresponsiveness manifested as increased albumin leakage in nasal fluids.

Positive_regulation (increased) of albumin Binding (leakage) of in nasal

7) Confidence 0.33 Published 1998 Journal Clin. Exp. Allergy Section Body Doc Link 9537786 Disease Relevance 0.10 Pain Relevance 0

Using blood samples collected within 2 hours of arrival at the Emergency Department, ischemia-modified albumin (noncobalt-binding albumin) was found to be increased in patients with unstable angina (sensitivity = 91%) [87].

Positive_regulation (increased) of albumin Binding (binding) of in blood associated with emergencies, ischemia and cva

8) Confidence 0.24 Published 2008 Journal Crit Care Section Body Doc Link PMC2481437 Disease Relevance 1.54 Pain Relevance 0.51

General Comments

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