INT36616

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Context Info
Confidence 0.67
First Reported 1972
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.00
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ALB) small molecule metabolic process (ALB) enzyme binding (ALB)
DNA binding (ALB) protein complex (ALB) transmembrane transport (ALB)
Anatomy Link Frequency
blood 2
nasal 2
ALB (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 100.00 Very High Very High Very High
methadone 4 100.00 Very High Very High Very High
Dynorphin 2 100.00 Very High Very High Very High
ischemia 11 99.42 Very High Very High Very High
cva 15 99.28 Very High Very High Very High
Opioid 2 98.90 Very High Very High Very High
Arthritis 54 91.84 High High
postherpetic neuralgia 2 84.08 Quite High
Analgesic 1 75.00 Quite High
anesthesia 2 68.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 39 100.00 Very High Very High Very High
Cv Unclassified Under Development 9 99.42 Very High Very High Very High
Angina 7 99.28 Very High Very High Very High
Emergencies 5 99.00 Very High Very High Very High
Cv General 4 Under Development 7 94.72 High High
Arthritis 56 91.84 High High
Myocardial Infarction 46 90.96 High High
Pressure And Volume Under Development 4 90.12 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 87.52 High High
Pulmonary Embolism 10 86.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The accumulation of a tripartite complex of TM, copper, and albumin turns over slowly.
Positive_regulation (accumulation) of albumin Binding (complex) of
1) Confidence 0.67 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297562 Disease Relevance 0.99 Pain Relevance 0.29
Structural requirements for binding of nonsteroidal anti-inflammatory drugs to human serum albumin.
Positive_regulation (requirements) of serum albumin Binding (binding) of associated with inflammation and cinod
2) Confidence 0.48 Published 1988 Journal J Pharm Sci Section Title Doc Link 3373430 Disease Relevance 0.20 Pain Relevance 0.29
The percent of methadone bound to albumin was relatively independent of the concentration of methadone, but was dependent on the concentration of albumin, ranging from 8.0 to 43.8 percent bound as the albumin concentration increased from 0.400 gram to 5.00 grams per 100 milliliters of solution.
Positive_regulation (dependent) of albumin Binding (bound) of associated with methadone
3) Confidence 0.47 Published 1972 Journal Science Section Abstract Doc Link 5032355 Disease Relevance 0 Pain Relevance 0.37
When the concentration of albumin was increased to 40?
Positive_regulation (increased) of albumin Binding (concentration) of
4) Confidence 0.44 Published 2009 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2778444 Disease Relevance 0.09 Pain Relevance 0
How do fatty acids cause allosteric binding of drugs to human serum albumin?
Positive_regulation (cause) of serum albumin Binding (binding) of
5) Confidence 0.43 Published 2002 Journal Pharm. Res. Section Title Doc Link 12425462 Disease Relevance 0 Pain Relevance 0.09
INTRODUCTION: CJC-1008 is a chemical modification of the opioid peptide dynorphin A (1-13) (Dyn A) that promotes dynorphin's covalent attachment to human serum albumin in vivo after administration, thus prolonging its duration of action.
Positive_regulation (promotes) of albumin Binding (attachment) of associated with dynorphin and opioid
6) Confidence 0.35 Published 2006 Journal J Opioid Manag Section Abstract Doc Link 17319450 Disease Relevance 0.07 Pain Relevance 0.51
CONCLUSIONS: We conclude that non-allergic rhinitis is not characterized by increased responsiveness of capsaicin-sensitive nerve fibres; while allergic rhinitis is marked by hyperresponsiveness manifested as increased albumin leakage in nasal fluids.
Positive_regulation (increased) of albumin Binding (leakage) of in nasal
7) Confidence 0.33 Published 1998 Journal Clin. Exp. Allergy Section Body Doc Link 9537786 Disease Relevance 0.10 Pain Relevance 0
Using blood samples collected within 2 hours of arrival at the Emergency Department, ischemia-modified albumin (noncobalt-binding albumin) was found to be increased in patients with unstable angina (sensitivity = 91%) [87].
Positive_regulation (increased) of albumin Binding (binding) of in blood associated with emergencies, ischemia and cva
8) Confidence 0.24 Published 2008 Journal Crit Care Section Body Doc Link PMC2481437 Disease Relevance 1.54 Pain Relevance 0.51

General Comments

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