INT36676

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Context Info
Confidence 0.36
First Reported 1988
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.41
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Pepd)
Anatomy Link Frequency
leg 1
Pepd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paroxysmal extreme pain disorder 9 100.00 Very High Very High Very High
burning pain 1 98.70 Very High Very High Very High
Pain 2 97.64 Very High Very High Very High
Glutamate 1 82.08 Quite High
addiction 2 66.00 Quite High
dorsal root ganglion 3 36.24 Quite Low
Trigeminal ganglion neurons 2 33.76 Quite Low
Disease Link Frequency Relevance Heat
Somatoform Disorder 9 100.00 Very High Very High Very High
Prolidase Deficiency 2 100.00 Very High Very High Very High
Syndrome 1 100.00 Very High Very High Very High
Pain 2 98.70 Very High Very High Very High
Leg Ulcer 2 98.52 Very High Very High Very High
Erythermalgia 9 98.06 Very High Very High Very High
Ganglion Cysts 5 35.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Hereditary prolidase deficiency in 2 sisters with therapy-resistant leg ulcers].
Gene_expression (deficiency) of prolidase in leg associated with prolidase deficiency and leg ulcer
1) Confidence 0.36 Published 1988 Journal Hautarzt Section Title Doc Link 3384668 Disease Relevance 0.20 Pain Relevance 0.09
Gain-of-function mutations of Na(V)1.7 have been shown to produce two distinct disorders: Na(V)1.7 mutations that enhance activation produce inherited erythromelalgia (IEM), characterized by burning pain in the extremities; Na(V)1.7 mutations that impair inactivation produce a different, nonoverlapping syndrome, paroxysmal extreme pain disorder (PEPD), characterized by rectal, periocular, and perimandibular pain.
Gene_expression (produce) of PEPD associated with somatoform disorder, pain, syndrome, paroxysmal extreme pain disorder, erythermalgia and burning pain
2) Confidence 0.03 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18945915 Disease Relevance 1.21 Pain Relevance 0.73

General Comments

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