INT36678

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Context Info
Confidence 0.36
First Reported 1988
Last Reported 2011
Negated 2
Speculated 4
Reported most in Body
Documents 33
Total Number 38
Disease Relevance 14.99
Pain Relevance 7.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TIMP1) extracellular region (TIMP1)
Anatomy Link Frequency
keratinocyte 2
joint 1
medial 1
cleavage 1
bladder 1
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 565 100.00 Very High Very High Very High
rheumatoid arthritis 341 98.84 Very High Very High Very High
Inflammatory mediators 10 98.48 Very High Very High Very High
cytokine 241 97.36 Very High Very High Very High
Arthritis 33 96.56 Very High Very High Very High
Angina 13 96.20 Very High Very High Very High
long-term potentiation 12 96.12 Very High Very High Very High
Inflammation 276 95.96 Very High Very High Very High
depression 226 94.44 High High
Enkephalin 3 93.44 High High
Disease Link Frequency Relevance Heat
Myocardial Infarction 113 99.72 Very High Very High Very High
Suicidal Behaviour 18 99.50 Very High Very High Very High
Major Depressive Disorder 75 99.20 Very High Very High Very High
Bladder Cancer 87 99.12 Very High Very High Very High
Blister 5 99.12 Very High Very High Very High
Rheumatoid Arthritis 341 98.84 Very High Very High Very High
INFLAMMATION 335 98.48 Very High Very High Very High
Metabolic Syndrome 59 98.48 Very High Very High Very High
Sudden Death 10 97.92 Very High Very High Very High
Adhesions 33 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For the complex interconnections between the various MMP components and pathways in tissue, Overall and Kleifeld [44] recently introduced the term "protease web" and underlined that the interactions between MMPs, TIMPs, and related components are more important than the single components.
TIMP Binding (interactions) of associated with metalloproteinase
1) Confidence 0.36 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.12 Pain Relevance 0.24
All TIMPs showed univariate association with the occurrence of MACEs (p <0.001).
TIMP Binding (association) of
2) Confidence 0.36 Published 2010 Journal Am. J. Cardiol. Section Abstract Doc Link 20691304 Disease Relevance 0.68 Pain Relevance 0.97
To our knowledge, there is no publication so far available on detection of MMPs and TIMPs in blood plasma for bladder cancer detection.
TIMP Neg (no) Binding (detection) of in bladder associated with bladder cancer and metalloproteinase
3) Confidence 0.36 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.96 Pain Relevance 0.20
With these ELISA techniques the non-active forms (proforms) of MMPs and in case of MTC1 the complex of MMP1 and TIMP1 were measured.
TIMP1 Binding (complex) of associated with metalloproteinase
4) Confidence 0.35 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.05 Pain Relevance 0.05
One possible explanation is that TIMP-3 is bound to the molecules of the extracellular matrix and is not exposed to B cells in circulation or in the joint cavity.
TIMP Binding (bound) of in cavity
5) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.60 Pain Relevance 0.30
After supplementation with EPA, but not with DHA, levels in docosapentaenoic acid increased.
EPA Binding (supplementation) of
6) Confidence 0.30 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993981 Disease Relevance 0.19 Pain Relevance 0
There is some debate as to whether this reflects better or faster absorption of EPA and DHA as phospholipids or as triglycerides or whether it relates to a slower but equally effective absorption of EPA and DHA as ethyl esters (Rupp et al 2004).
EPA Binding (absorption) of
7) Confidence 0.30 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993981 Disease Relevance 0.15 Pain Relevance 0
In one study, dogs were subjected to experimental myocardial infarction after 8 week supplementing with EPA.
EPA Binding (supplementing) of associated with myocardial infarction
8) Confidence 0.30 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993981 Disease Relevance 0.22 Pain Relevance 0
All these experimental data further support our findings on the immunomodulatory role of antibodies against TIMP-1 and TIMP-2 in patients with RA.
TIMP-1 Binding (findings) of associated with rheumatoid arthritis
9) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.91 Pain Relevance 0.34
Interaction between TIMP blotted to the PVDF membrane and human IgG was visualized using horseradish-peroxidase-labelled antibodies (rabbit F(ab')2-antihuman IgG; DAKO), and aminoethylcarbazole substrate in sodium acetate buffer (pH 5.5).
TIMP Binding (Interaction) of
10) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.21 Pain Relevance 0.07
The amino-terminal domain of TIMP binds the active site of MMPs, inhibiting their proteolytic activity.
TIMP Binding (binds) of associated with metalloproteinase
11) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.31 Pain Relevance 0.46
Extracellular stimulation with TIMP-1 and TIMP-2 is recognized by specific surface receptors and activates cascades dependent on mitogen-activated protein kinase (MAPK) and on tyrosine kinase [22].
TIMP-1 Binding (recognized) of
12) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 1.04 Pain Relevance 0.37
201), The assay recognises free TIMP-1 and TIMP-1 complexed with MMPs, with a lower detection limit of 1.25 ng/mL and a CV of 6.8%.
TIMP Binding (recognises) of
13) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258002 Disease Relevance 0 Pain Relevance 0.04
201), The assay recognises free TIMP-1 and TIMP-1 complexed with MMPs, with a lower detection limit of 1.25 ng/mL and a CV of 6.8%.
TIMP Binding (recognises) of
14) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2258002 Disease Relevance 0 Pain Relevance 0.04
Suicide attempts have also been associated with low levels of RBC EPA.
RBC EPA Binding (associated) of associated with suicidal behaviour
15) Confidence 0.21 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC533861 Disease Relevance 1.28 Pain Relevance 0.20
To measure collagenase activity, TGF?
collagenase Binding (activity) of
16) Confidence 0.16 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0 Pain Relevance 0.04
Keratinocytes were subsequently plated upon these matrices in the presence or absence of Clostridial collagenase and/or heparin-binding epidermal-like growth factor, and cell proliferation and migration were quantified.
collagenase Binding (binding) of in Keratinocytes
17) Confidence 0.16 Published 2005 Journal Journal of Burns and Wounds Section Abstract Doc Link PMC1501117 Disease Relevance 0.31 Pain Relevance 0
Similarily, EPA was taken up by the cells and was elongated to 22:5n-3, since the amount of this fatty acid increased from 0.5 ± 0.046 ?
EPA Binding (22:5n) of
18) Confidence 0.15 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0
B and mitogen-activating protein kinase pathways; by activation, MMPs are secreted as inactive zymogen and require the proteolytic cleavage of the prodomain for activation; and by inhibition, by the tissue inhibitors of metalloproteinases (TIMPs) that bind to activated MMPs.
metalloproteinases Binding (bind) of in cleavage associated with metalloproteinase
19) Confidence 0.15 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154424 Disease Relevance 0 Pain Relevance 0.48
pocket of metalloproteinases and the substances which can show competence to bind with the active site of metalloproteinases is much challenging.
metalloproteinases Binding (bind) of associated with metalloproteinase
20) Confidence 0.15 Published 2010 Journal Biochemistry Research International Section Body Doc Link PMC3004377 Disease Relevance 0 Pain Relevance 0.17

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