INT36698

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Context Info
Confidence 0.48
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.97
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CHRM3) signal transduction (CHRM3) protein modification process (CHRM3)
small molecule metabolic process (CHRM3) plasma membrane (CHRM3) signal transducer activity (CHRM3)
Anatomy Link Frequency
salivary gland 1
CHRM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
methadone 2 99.64 Very High Very High Very High
MU agonist 2 99.44 Very High Very High Very High
analgesia 5 96.20 Very High Very High Very High
Pain 4 94.64 High High
antagonist 12 92.24 High High
Potency 3 89.20 High High
anesthesia 4 87.36 High High
spastic colon 1 87.00 High High
aspirin 1 81.20 Quite High
Dopamine 2 61.56 Quite High
Disease Link Frequency Relevance Heat
Urolithiasis 2 99.58 Very High Very High Very High
Heart Rate Under Development 2 97.12 Very High Very High Very High
Pressure Volume 2 Under Development 1 95.40 Very High Very High Very High
Urinary Calculi 7 92.16 High High
Overactive Bladder 1 90.00 High High
Shock 26 89.76 High High
Chronic Obstructive Pulmonary Disease 2 88.96 High High
Congenital Anomalies 1 88.72 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 87.20 High High
Functional Bowel Disorder 1 87.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, zamifenacin had lower affinity for the M3 receptor in the salivary gland (pKi 7.97).
M3 receptor Binding (affinity) of in salivary gland
1) Confidence 0.48 Published 1995 Journal Life Sci. Section Abstract Doc Link 10188786 Disease Relevance 0.35 Pain Relevance 0.27
[Extracorporeal shockwave lithotripsy in the treatment of urolithiasis--experiences from a center with the Piezolith 2200 and HM3 lithotriptors].
HM3 Binding (center) of associated with urolithiasis
2) Confidence 0.36 Published 1988 Journal Z Urol Nephrol Section Title Doc Link 3388994 Disease Relevance 0.68 Pain Relevance 0.17
Certainly for some targets it seems unlikely that clinical response is related to genetic variation; the muscarinic M3 receptor has not so far been found to contain any common coding-region polymorphisms [29] and the extent of polymorphic variation within both the histamine H1 receptor and the Cys-leukotriene 1 receptor is much lower than that of the ?
M3 receptor Binding (found) of
3) Confidence 0.14 Published 2002 Journal Respir Res Section Body Doc Link PMC64808 Disease Relevance 0.13 Pain Relevance 0.08
Nevertheless, the efficacy of treatment with these newer devices is significantly lower when compared to the HM3.22,23
HM3 Binding (compared) of
4) Confidence 0.05 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2972613 Disease Relevance 0.37 Pain Relevance 0.46
-opioid agonist methadone was predicted to bind to the muscarinic M3 receptor (22); this is consistent with, though of course far from establishes the basis of, methadone’s unusual side effects for an opioid agonist, including the heavy sweating that patients report with it.
muscarinic M3 receptor Binding (bind) of associated with mu agonist and methadone
5) Confidence 0.03 Published 2010 Journal Biochemistry Section Body Doc Link PMC2994275 Disease Relevance 0.34 Pain Relevance 0.50

General Comments

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