INT36715

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Context Info
Confidence 0.68
First Reported 1983
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 50
Total Number 56
Disease Relevance 4.18
Pain Relevance 11.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpc4) protein complex (Trpc4) transmembrane transport (Trpc4)
cytoplasm (Trpc4)
Anatomy Link Frequency
brain 11
neuronal 4
striatum 3
neurons 3
cortex 3
Trpc4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 12 100.00 Very High Very High Very High
Dynorphin 8 100.00 Very High Very High Very High
qutenza 4 99.84 Very High Very High Very High
amygdala 134 99.76 Very High Very High Very High
Hippocampus 1032 99.74 Very High Very High Very High
Pyramidal cell 473 99.52 Very High Very High Very High
Analgesic 6 99.22 Very High Very High Very High
Kinase C 86 99.20 Very High Very High Very High
Nucleus accumbens 258 98.32 Very High Very High Very High
TRP channel 89 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 258 99.72 Very High Very High Very High
Hypersensitivity 86 95.24 Very High Very High Very High
Acidosis 2 91.72 High High
Death 44 81.60 Quite High
Nociception 1 75.80 Quite High
Cv Unclassified Under Development 1 69.72 Quite High
INFLAMMATION 1 69.28 Quite High
Pain 2 51.92 Quite High
Depression 43 5.00 Very Low Very Low Very Low
Targeted Disruption 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conformation and biological studies of synthesized Trp4-Met5 enkephalin N-protected with 3,5-dimethoxy-alpha, alpha-dimethylbenzoylcarbonyl group.
Gene_expression (synthesized) of Trp4-Met5 associated with analgesic and enkephalin
1) Confidence 0.68 Published 1988 Journal Pharmazie Section Title Doc Link 3393577 Disease Relevance 0 Pain Relevance 0.57
A highly purified Trp4-Met5 enkephalin was synthesized using liquid phase method of peptide synthesis.
Gene_expression (synthesized) of Trp4-Met5 associated with enkephalin
2) Confidence 0.68 Published 1988 Journal Pharmazie Section Abstract Doc Link 3393577 Disease Relevance 0 Pain Relevance 0.24
TRPC4 transcripts are also detected in capsaicin-sensitive dorsal root ganglia neurons.
Gene_expression (detected) of TRPC4 in neurons associated with qutenza
3) Confidence 0.65 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16115206 Disease Relevance 0.08 Pain Relevance 0.32
Developmental expression of TRPC4 and 5 proteins
Gene_expression (expression) of TRPC4
4) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.12
To examine the cortical layer-specific expression of TRPC4 and 5 in the frontal cortex, we performed quantitative analysis of the in situ hybridization signal in the superficial (layers 2/3) and deep (layer 5/6) cortical layers.
Spec (examine) Gene_expression (expression) of TRPC4 in frontal cortex associated with urological neuroanatomy
5) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0.33 Pain Relevance 0.31
In both species TRPC4 expression is very high in CA1 while moderate expression in CA2 and DG, and little expression in CA3 and hilus is observed.
Gene_expression (expression) of TRPC4 in hilus
6) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0.31 Pain Relevance 0.41
The rationale for using the background region as the control is that because we are examining the expression of TRPC4 and 5 in different brain regions within the same slice, instead of the differences in expression in the same region across different slices, using a region of the tissue without a specific signal has an advantage because it does not assume expression or lack of expression in any brain regions.
Gene_expression (expression) of TRPC4 in brain
7) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0.13 Pain Relevance 0
Expression of both TRPC4 and 5 in the cell body layer of the HIP provides evidence that these channels are present in pyramidal neurons in the HIP.
Gene_expression (Expression) of TRPC4 in pyramidal neurons associated with pyramidal cell and hippocampus
8) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.30
Real-time PCR of the seven TRPC channels in microdissections of the LS of adult rat confirms that TRPC4 is the predominantly expressed channel in the LS, comprising 66% of the TRPC channel population.
Gene_expression (expressed) of TRPC4
9) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.06
In adults, TRPC4 expression was high throughout the frontal cortex, lateral septum (LS), pyramidal cell layer of the hippocampus (HIP), dentate gyrus (DG), and ventral subiculum (vSUB).
Gene_expression (expression) of TRPC4 in dentate gyrus associated with pyramidal cell, urological neuroanatomy and hippocampus
10) Confidence 0.65 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1892805 Disease Relevance 0.18 Pain Relevance 0.32
Region-specific protein expression of TRPC4 and TRPC5
Gene_expression (expression) of TRPC4
11) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.03
Results of TRPC5 protein expression from immunoblots from rat striatum, PFC, and LS show that TRPC4 protein is most highly expressed in the LS and moderately expressed in the PFC with lower expression in the striatum.
Gene_expression (expressed) of TRPC4 protein in striatum
12) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.05
Results of TRPC5 protein expression from immunoblots from rat striatum, PFC, and LS show that TRPC4 protein is most highly expressed in the LS and moderately expressed in the PFC with lower expression in the striatum.
Gene_expression (expressed) of TRPC4 protein in striatum
13) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.06
As with TRPC4, no significant TRPC5 expression was detected in layer 1 of the PFC where there are few neuronal cell bodies.
Gene_expression (expression) of TRPC4 in neuronal
14) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0.11 Pain Relevance 0.38
The protein expression of TRPC4 and TRPC5 correspond with the mRNA expression for each channel in regions such as the PFC, LS, and HIP; however, in the nucleus accumbens TRPC5 mRNA is expressed at low to moderate levels yet the protein is expressed at moderate to high levels.
Gene_expression (expression) of TRPC4 in nucleus accumbens associated with nucleus accumbens and hippocampus
15) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.26
Results show that TRPC4 mRNA is expressed at similar levels throughout layers 2,3,5, and 6 in all regions of the frontal cortex, including the PFC, anterior cingulate, MCx, SCx and orbitofrontal cortex.
Gene_expression (expressed) of TRPC4 mRNA in cortex associated with somatosensory cortex, urological neuroanatomy and anterior cingulate
16) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0.35 Pain Relevance 0.35
In situ hybridization histochemistry and immunoblotting further resolved a dense corticolimbic expression of the TRPC4 and TRPC5 channels.
Gene_expression (expression) of TRPC4
17) Confidence 0.65 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1892805 Disease Relevance 0.15 Pain Relevance 0.21
Coronal and horizontal brain slices show that TRPC4 mRNA is highly expressed in the LS and cell body layer of the CA1-CA2 sub-regions of the HIP, vSUB, and dorsal tenia tecta (Figure 3).
Gene_expression (expressed) of TRPC4 mRNA in cell body associated with hippocampus
18) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0.14 Pain Relevance 0.17
The dense pyramidal neuron-specific corticolimbic expression of TRPC4 and 5 channels in the brain suggests that they may be involved in modulating synaptic plasticity associated with learning and memory.
Gene_expression (expression) of TRPC4 in pyramidal neuron associated with pyramidal cell
19) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.40
To determine if TRPC4 or 5 protein expression is developmentally regulated, we examined expression at different stages of development in the HIP.
Gene_expression (expression) of TRPC4 associated with hippocampus
20) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.13

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