INT36716

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Context Info
Confidence 0.68
First Reported 1988
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 3.48
Pain Relevance 3.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tspo)
Tspo (Mus musculus)
Pain Link Frequency Relevance Heat
Versed 32 99.84 Very High Very High Very High
Neuropathic pain 2 99.04 Very High Very High Very High
Pain 7 98.44 Very High Very High Very High
gABA 3 97.44 Very High Very High Very High
antagonist 8 97.28 Very High Very High Very High
Inflammation 14 96.60 Very High Very High Very High
imagery 32 95.16 Very High Very High Very High
positron emission tomography 18 94.84 High High
Analgesic 2 94.76 High High
allodynia 1 94.60 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 3 99.04 Very High Very High Very High
Pain 2 98.44 Very High Very High Very High
Cancer 8 98.24 Very High Very High Very High
INFLAMMATION 18 96.60 Very High Very High Very High
Nervous System Injury 3 95.52 Very High Very High Very High
Amyloid Plaque 32 94.16 High High
Hyperalgesia 2 94.04 High High
Nociception 1 88.04 High High
Alzheimer's Dementia 20 87.56 High High
Cognitive Disorder 28 82.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PBR, P450scc, 3beta-HSD and StAR protein expression induced by MDZ was determined by Western blotting.
Positive_regulation (induced) of Gene_expression (expression) of PBR associated with versed
1) Confidence 0.68 Published 2010 Journal Toxicol. Lett. Section Abstract Doc Link 19857560 Disease Relevance 0.17 Pain Relevance 0.61
In both cell types, MDZ-stimulated steroidogenesis in dose- and time-dependent manners, and induced the expression of PBR and StAR proteins, but had no effect on P450scc and 3beta-HSD expressions.
Positive_regulation (induced) of Gene_expression (expression) of PBR associated with versed
2) Confidence 0.49 Published 2010 Journal Toxicol. Lett. Section Abstract Doc Link 19857560 Disease Relevance 0.27 Pain Relevance 0.73
For example, increased expression of peripheral benzodiazepine receptor (PBR) has been target for the compound [11C] (R)-PK11195.
Positive_regulation (increased) of Gene_expression (expression) of PBR
3) Confidence 0.49 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.05 Pain Relevance 0.32
In the present study, we first tested whether the enhanced PBR expression is causally related to neuropathic pain, and we found that the PBR antagonist PK11195 is effective in reducing SNL-induced mechanical allodynia and thermal hyperalgesia.
Spec (whether) Positive_regulation (enhanced) of Gene_expression (expression) of PBR associated with nervous system injury, allodynia, thermal hyperalgesia, antagonist and neuropathic pain
4) Confidence 0.46 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19403993 Disease Relevance 0.68 Pain Relevance 0.74
Despite certain inconsistencies in the literature, present data provide further support for benzodiazepine receptor mediation of this ecologically-relevant form of pain inhibition.
Positive_regulation (support) of Gene_expression (mediation) of benzodiazepine receptor associated with pain
5) Confidence 0.43 Published 1988 Journal Physiol. Behav. Section Abstract Doc Link 3393607 Disease Relevance 0.26 Pain Relevance 0.78
For example, increased expression of peripheral benzodiazepine receptor (PBR) has been target for the compound [11C] (R)-PK11195.
Positive_regulation (increased) of Gene_expression (expression) of benzodiazepine receptor
6) Confidence 0.08 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.04 Pain Relevance 0.32

General Comments

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