INT36764

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Context Info
Confidence 0.80
First Reported 1982
Last Reported 2007
Negated 2
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.53
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ace) peptidase activity (Ace) extracellular space (Ace)
extracellular region (Ace) plasma membrane (Ace)
Anatomy Link Frequency
brain 1
Ace (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 5 100.00 Very High Very High Very High
bradykinin 10 99.24 Very High Very High Very High
Inflammation 9 62.76 Quite High
antagonist 4 50.72 Quite High
Analgesic 1 47.04 Quite Low
anesthesia 5 25.00 Low Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Catecholamine 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypotension 5 99.24 Very High Very High Very High
Death 3 95.36 Very High Very High Very High
Myocardial Infarction 47 94.92 High High
Heart Rate Under Development 3 89.96 High High
Pressure And Volume Under Development 12 88.52 High High
Increased Venous Pressure Under Development 9 83.76 Quite High
INFLAMMATION 9 62.76 Quite High
Chronic Renal Failure 1 61.72 Quite High
Hypertension 1 59.64 Quite High
Left Ventricular Dysfunction 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that Bulbus Fritillaria extracts have a hypotensive effect in rats via the inhibition of ACE activity and direct release of NO/cGMP in the vascular tissue.
Localization (release) of ACE associated with hypotension
1) Confidence 0.80 Published 2002 Journal J Ethnopharmacol Section Abstract Doc Link 12020927 Disease Relevance 0.23 Pain Relevance 0
These results suggest that berberine has a hypotensive effect, at least in part, via the inhibition of ACE and direct release of NO/cGMP in the vascular tissues.
Localization (release) of ACE associated with hypotension
2) Confidence 0.79 Published 2002 Journal Vascul. Pharmacol. Section Abstract Doc Link 14567065 Disease Relevance 0.10 Pain Relevance 0
Incubation of tissue samples with specific polyclonal antibodies and 125I-protein A, followed by autoradiography, allows the permanent recording of the radioimmunohistochemical localization of brain methionine-enkephalin, tyrosine hydroxylase, and angiotensin-converting enzyme and of pituitary vasopressin and could be applied to the localization of many other tissue antigens. 4.
Localization (localization) of angiotensin-converting enzyme in brain associated with enkephalin
3) Confidence 0.78 Published 1988 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 3401900 Disease Relevance 0 Pain Relevance 0.27
In a subset analysis, 366 patients who were not receiving ACE inhibitors were randomly assigned to either valsartan or placebo.
Neg (not) Localization (receiving) of ACE
4) Confidence 0.71 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 0.66 Pain Relevance 0.03
The present study was designed to investigate whether the Bulbus Fritillaria shows a hypotensive effect via the angiotensin converting enzyme (ACE) inhibition and elicit NO/cGMP release in rat aortic rings.
Neg (NO) Localization (release) of ACE associated with hypotension
5) Confidence 0.70 Published 2002 Journal J Ethnopharmacol Section Abstract Doc Link 12020927 Disease Relevance 0.17 Pain Relevance 0
The release of ALP and ACE as biomarkers of epithelial and endothelial integrity are not elevated during the perfusion and do not correspond to the small translocation of 192Ir after a lag-time of about 60 min -UFP.
Localization (release) of ACE
6) Confidence 0.37 Published 2005 Journal Part Fibre Toxicol Section Body Doc Link PMC1180470 Disease Relevance 0.12 Pain Relevance 0.03
Using the coaxial perfusion technique it was found that in the 15-min period from 15 to 30 min after immersing the highest amount of bradykinin-like substance was obtained, and the release of kininogen, kinin-forming enzyme and kininase was markedly increased.
Localization (release) of kininase associated with bradykinin
7) Confidence 0.20 Published 1982 Journal Arzneimittelforschung Section Abstract Doc Link 7201806 Disease Relevance 0.25 Pain Relevance 0.19

General Comments

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