INT36767

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Context Info
Confidence 0.20
First Reported 1982
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 4.13
Pain Relevance 4.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Atp7b) Golgi apparatus (Atp7b) plasma membrane (Atp7b)
Anatomy Link Frequency
coronary artery 1
PMNs 1
platelet 1
Atp7b (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 7 99.56 Very High Very High Very High
Angina 31 98.72 Very High Very High Very High
ischemia 6 98.20 Very High Very High Very High
Dynorphin 3 97.92 Very High Very High Very High
Morphine 6 96.86 Very High Very High Very High
rheumatoid arthritis 1 94.96 High High
anesthesia 3 94.48 High High
Dopamine 2 90.00 High High
Restless leg syndrome 3 89.16 High High
aspirin 6 89.04 High High
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 2 99.74 Very High Very High Very High
Coronary Artery Disease 1 99.28 Very High Very High Very High
Cv General 3 Under Development 31 98.72 Very High Very High Very High
Cv Unclassified Under Development 7 98.20 Very High Very High Very High
Disease 7 97.80 Very High Very High Very High
Myocardial Infarction 6 95.80 Very High Very High Very High
Rheumatoid Arthritis 1 94.96 High High
Increased Venous Pressure Under Development 9 89.16 High High
Thrombosis Related Under Development 1 77.40 Quite High
INFLAMMATION 2 75.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 14 VO patients were then studied by rapid atrial pacing to detect TxB2 release coinciding with pacing-induced angina and myocardial lactate production.
Localization (release) of TxB2 associated with angina
1) Confidence 0.20 Published 1983 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 6407435 Disease Relevance 0.84 Pain Relevance 0.58
Although antiplatelet agent will block all TxB2 release even in VO, their clinical potential seems greatest in VA.
Localization (release) of TxB2 associated with angina
2) Confidence 0.18 Published 1983 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 6407435 Disease Relevance 0.80 Pain Relevance 0.50
In the latter groups, basal TxB2 release was absent.
Neg (absent) Localization (release) of TxB2
3) Confidence 0.18 Published 1983 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 6407435 Disease Relevance 0.73 Pain Relevance 0.55
After 0.4 mg kg(-1) ketorolac i.v. platelet aggregation and TxB2 formation are inhibited more in comparison with propacetamol, and platelet dysfunction is still seen after 24 h.


Localization (formation) of TxB2 in platelet
4) Confidence 0.03 Published 2000 Journal Acta Anaesthesiol Scand Section Body Doc Link 10669275 Disease Relevance 0 Pain Relevance 0
COX-1(-/-) had a 89% reduction (P<0.0001) in the excretion of TxB2, a 76% reduction (P<0.01) in PGE2, a 40% reduction (P<0.0002) in 6-ketoPGF1alpha (6keto), a 27% reduction (P<0.02) in 11-betaPGF2alpha (11beta), a 35% reduction (P<0.01) in nitrate plus nitrite (NOx), and a 52% increase in metanephrine (P<0.02).
Localization (excretion) of TxB2
5) Confidence 0.03 Published 2005 Journal Hypertension Section Abstract Doc Link 15883230 Disease Relevance 0.07 Pain Relevance 0.09
The basal excretion of Tx-M was 105 +/- 26 pg/mg creatinine.
Localization (excretion) of Tx-M
6) Confidence 0.01 Published 1988 Journal Clin Physiol Section Abstract Doc Link 3402185 Disease Relevance 0.61 Pain Relevance 0.36
Intraoperatively, creatinine clearance and urinary excretion of PGE2, 6-keto PGF1 alpha and TxB2 were also determined before, during and after aortic crossclamping.
Localization (excretion) of TxB2 associated with disorders of creatine metabolism
7) Confidence 0.01 Published 1996 Journal Nephron Section Abstract Doc Link 8956299 Disease Relevance 0.31 Pain Relevance 0.14
Morphine was found to inhibit PMNs aggregation induced by PHA (0.01), PMA (0.01), fMLP (0.01) and Ca++ ionophore (p < 0.01), ATP release (p < 0.01), thromboxane B2 (TxB2) and leukotriene B4 (LTB4) secretion during cell aggregation.
Localization (secretion) of TxB2 in PMNs associated with morphine
8) Confidence 0.01 Published 1993 Journal Riv Eur Sci Med Farmacol Section Abstract Doc Link 7909619 Disease Relevance 0 Pain Relevance 1.25
PGE2 and TxB2 are released in large quantities and are increased after stimulation with zymosan.
Localization (released) of TxB2
9) Confidence 0.01 Published 1982 Journal Rev Rhum Mal Osteoartic Section Abstract Doc Link 7123126 Disease Relevance 0.24 Pain Relevance 0.05
Effects of gallopamil on epinephrine and norepinephrine plasmatic levels and on TxB2 and beta-tg release in patients with coronary artery disease during adrenergic stimulus with cold pressor test.
Localization (release) of TxB2 in coronary artery associated with coronary artery disease
10) Confidence 0.01 Published 1995 Journal Pharmacol. Res. Section Title Doc Link 8668647 Disease Relevance 0.45 Pain Relevance 0.47
After furosemide, all NSAIDs decreased fractional excretions of Na+ and Cl-, PRA, and TxB2 by equivalent degrees (P less than 0.05).
Localization (excretions) of TxB2 associated with cinod
11) Confidence 0.00 Published 1985 Journal Kidney Int. Section Abstract Doc Link 3884880 Disease Relevance 0.08 Pain Relevance 0.51

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