INT36770

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Context Info
Confidence 0.70
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 10.42
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pth) extracellular region (Pth) cellular_component (Pth)
Anatomy Link Frequency
parathyroid 18
parathyroid gland 2
Pth (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 1 97.52 Very High Very High Very High
Pain 22 89.68 High High
Restless leg syndrome 1 61.52 Quite High
fibrosis 6 53.92 Quite High
imagery 10 24.92 Low Low
cytokine 2 22.16 Low Low
Inflammation 10 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
neuralgia 2 5.00 Very Low Very Low Very Low
Earache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypocalcemia 2 99.98 Very High Very High Very High
Acid Base Imbalance 68 99.52 Very High Very High Very High
Hypercalcemia 86 98.52 Very High Very High Very High
Parathyroid Cancer 11 97.68 Very High Very High Very High
Osteitis 4 97.24 Very High Very High Very High
Rickets 4 96.12 Very High Very High Very High
Chronic Renal Failure 124 95.76 Very High Very High Very High
Metastasis 6 94.48 High High
Osteoporosis 28 93.84 High High
Hyperplasia 56 93.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These effects were not correlated with anesthesia or immobilization, and we suggest that inaktin-induced changes in calcium metabolism involve an impairment of hypocalcemia-induced parathyroid hormone secretion, in addition to the impairment of parathyroid hormone effects previously reported.
Positive_regulation (induced) of Localization (secretion) of parathyroid hormone in parathyroid associated with hypocalcemia and anesthesia
1) Confidence 0.70 Published 1988 Journal Fundam Clin Pharmacol Section Abstract Doc Link 3402897 Disease Relevance 0.10 Pain Relevance 0.10
We conclude that EDTA treatment increases endogenous PTH secretion considerably and leads to increased bone resorption.
Positive_regulation (increases) of Localization (secretion) of PTH associated with hypercalcemia
2) Confidence 0.64 Published 1993 Journal Dan Med Bull Section Abstract Doc Link 8299406 Disease Relevance 0.32 Pain Relevance 0.06
In response to the fall in serum calcium levels, PTH secretion increases as a compensatory mechanism to maintain mineral homeostasis.
Positive_regulation (increases) of Localization (secretion) of PTH
3) Confidence 0.47 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.45 Pain Relevance 0
There is convincing evidence that parathyroid gland secretion of PTH is stimulated by hypocalcemia, whereas secretion of C-terminal fragments is promoted by hypercalcemia.
Positive_regulation (stimulated) of Localization (secretion) of PTH in parathyroid gland associated with hypocalcemia and hypercalcemia
4) Confidence 0.46 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684083 Disease Relevance 0.41 Pain Relevance 0
Phosphorus retention and reduced synthesis of 1–25 vitamin D result in low serum calcium levels, which causes a feedback secretion of intact parathyroid hormone (iPTH).
Positive_regulation (causes) of Localization (secretion) of parathyroid hormone in parathyroid
5) Confidence 0.44 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2644631 Disease Relevance 0.62 Pain Relevance 0
Glandular volume is a key marker for the severity of sHPT and increased secretion of iPTH [3,8].
Positive_regulation (increased) of Localization (secretion) of iPTH
6) Confidence 0.41 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2644631 Disease Relevance 0.66 Pain Relevance 0
We sequentially measured the serum concentrations of bone alkaline phosphatase [by an electrophoretic technique (BALP)], carboxy-terminal telopeptide of type I collagen (ICTP), calcium (CaS), intact parathyroid hormone (PTH), and the fasting urinary excretion of calcium (Ca:Cr).
Positive_regulation (concentrations) of Localization (excretion) of parathyroid hormone in parathyroid
7) Confidence 0.35 Published 1999 Journal Clin. Chem. Section Body Doc Link 10430790 Disease Relevance 0.28 Pain Relevance 0
We sequentially measured the serum concentrations of bone alkaline phosphatase [by an electrophoretic technique (BALP)], carboxy-terminal telopeptide of type I collagen (ICTP), calcium (CaS), intact parathyroid hormone (PTH), and the fasting urinary excretion of calcium (Ca:Cr).
Positive_regulation (concentrations) of Localization (excretion) of PTH in parathyroid
8) Confidence 0.35 Published 1999 Journal Clin. Chem. Section Body Doc Link 10430790 Disease Relevance 0.28 Pain Relevance 0
PTH secretion is stimulated by chronic metabolic acidosis in humans [36].
Positive_regulation (stimulated) of Localization (secretion) of PTH associated with acid base imbalance
9) Confidence 0.18 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2991191 Disease Relevance 1.36 Pain Relevance 0.03
Calcitonin administration caused a mean increase in parathyroid hormone (PTH) secretion 3.6 +/- 1.5 to 6.5 +/- 1.7 ng/ml; p less than 0.05) after 6 weeks of therapy.
Positive_regulation (caused) of Localization (secretion) of parathyroid hormone in parathyroid
10) Confidence 0.15 Published 1984-1985 Journal Uremia Invest Section Abstract Doc Link 6537690 Disease Relevance 0.75 Pain Relevance 0.09
Calcitonin administration caused a mean increase in parathyroid hormone (PTH) secretion 3.6 +/- 1.5 to 6.5 +/- 1.7 ng/ml; p less than 0.05) after 6 weeks of therapy.
Positive_regulation (increase) of Localization (secretion) of PTH in parathyroid
11) Confidence 0.11 Published 1984-1985 Journal Uremia Invest Section Abstract Doc Link 6537690 Disease Relevance 0.75 Pain Relevance 0.09
Calcitonin administration caused a mean increase in parathyroid hormone (PTH) secretion 3.6 +/- 1.5 to 6.5 +/- 1.7 ng/ml; p less than 0.05) after 6 weeks of therapy.
Positive_regulation (increase) of Localization (secretion) of parathyroid hormone in parathyroid
12) Confidence 0.10 Published 1984-1985 Journal Uremia Invest Section Abstract Doc Link 6537690 Disease Relevance 0.75 Pain Relevance 0.09
This results in increased synthesis and release of parathyroid hormone (PTH).
Positive_regulation (increased) of Localization (release) of parathyroid hormone in parathyroid
13) Confidence 0.06 Published 2008 Journal European Journal of Dentistry Section Body Doc Link PMC2635909 Disease Relevance 1.84 Pain Relevance 0
This results in increased synthesis and release of parathyroid hormone (PTH).
Positive_regulation (results) of Localization (release) of parathyroid hormone in parathyroid
14) Confidence 0.06 Published 2008 Journal European Journal of Dentistry Section Body Doc Link PMC2635909 Disease Relevance 1.85 Pain Relevance 0

General Comments

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