INT36772

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Context Info
Confidence 0.69
First Reported 1983
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 1.73
Pain Relevance 3.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) cytoplasm (Oxt)
Anatomy Link Frequency
uterine 6
plasma 2
myometrium 2
margin 2
neuron 2
Oxt (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 19 100.00 Very High Very High Very High
Dismenorea 19 99.80 Very High Very High Very High
Action potential 2 95.60 Very High Very High Very High
Opioid 7 88.40 High High
antagonist 3 88.08 High High
epidural 7 88.00 High High
medulla 6 87.60 High High
analgesia 6 83.64 Quite High
gABA 2 78.60 Quite High
Pain 1 74.44 Quite High
Disease Link Frequency Relevance Heat
Dysmenorrhea 19 99.80 Very High Very High Very High
Stress 4 83.76 Quite High
Pain 1 74.44 Quite High
Newborn Jaundice 1 71.36 Quite High
Targeted Disruption 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During parturition, oxytocin cells increase their basal activity, and hence oxytocin secretion increases.
Positive_regulation (increase) of Positive_regulation (increases) of oxytocin
1) Confidence 0.69 Published 2003 Journal Front Neuroendocrinol Section Abstract Doc Link 12609499 Disease Relevance 0.06 Pain Relevance 0.50
Oxytocin neurones were activated during birth as shown by both increased immediate early gene ( Fos) expression in oxytocin neurones in the supraoptic nucleus and increased plasma oxytocin concentrations during birth.
Positive_regulation (increased) of Positive_regulation (increased) of oxytocin in plasma
2) Confidence 0.50 Published 2002 Journal Reproduction Section Abstract Doc Link 11914117 Disease Relevance 0.15 Pain Relevance 0.11
We conclude that morphine could be used as an inhibitor of nocturnal uterine contractions, and that this is caused by the morphine induced increased metabolic clearance rate of oxytocin.
Positive_regulation (caused) of Positive_regulation (increased) of oxytocin in uterine associated with dismenorea and morphine
3) Confidence 0.50 Published 2002 Journal Yonsei Med. J. Section Abstract Doc Link 12402368 Disease Relevance 0.33 Pain Relevance 0.83
Cyto-architectonic changes in parturition, involving evident retraction of glial processes between oxytocin cells so they get closer together, are probably a response to oxytocin neuron activation rather than being essential for their patterns of firing in parturition.
Positive_regulation (response) of Positive_regulation (activation) of oxytocin in neuron
4) Confidence 0.50 Published 2003 Journal Front Neuroendocrinol Section Abstract Doc Link 12609499 Disease Relevance 0 Pain Relevance 0.11
We conclude that morphine could be used as an inhibitor of nocturnal uterine contractions, and that this is caused by the morphine induced increased metabolic clearance rate of oxytocin.
Positive_regulation (caused) of Positive_regulation (induced) of oxytocin in uterine associated with dismenorea and morphine
5) Confidence 0.50 Published 2002 Journal Yonsei Med. J. Section Abstract Doc Link 12402368 Disease Relevance 0.33 Pain Relevance 0.83
We conclude that morphine could be used as an inhibitor of nocturnal uterine contractions, and that this is caused by the morphine induced increased metabolic clearance rate of oxytocin.
Positive_regulation (increased) of Positive_regulation (induced) of oxytocin in uterine associated with dismenorea and morphine
6) Confidence 0.50 Published 2002 Journal Yonsei Med. J. Section Abstract Doc Link 12402368 Disease Relevance 0.33 Pain Relevance 0.82
Our study demonstrates that pulsed administration of oxytocin every 8 minutes is as effective and safe as continuous intravenous infusion of oxytocin for induction of labor, requires less oxytocin with therefore, a wider margin of safety and is consistent with the pulsatile release of oxytocin during normal labor.
Positive_regulation (effective) of Positive_regulation (infusion) of oxytocin in margin
7) Confidence 0.49 Published 1988 Journal J Perinat Med Section Abstract Doc Link 3404378 Disease Relevance 0.07 Pain Relevance 0.07
RESULTS: When compared with the group receiving narcotic analgesia (n = 45), the group receiving epidural analgesia (n = 48) had a significant prolongation in the first and second stages of labor, an increased requirement for oxytocin augmentation, and a significant slowing in the rate of cervical dilatation.
Positive_regulation (increased) of Positive_regulation (requirement) of oxytocin
8) Confidence 0.49 Published 1993 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 8238138 Disease Relevance 0 Pain Relevance 0
When oxytocin was used electively there was a reduction in the length of the first stage of labour from 696 min to 578 min, (P < 0.05) even though more than half of the control group (53%) required oxytocin augmentation.
Positive_regulation (required) of Positive_regulation (augmentation) of oxytocin
9) Confidence 0.46 Published 1995 Journal Int J Obstet Anesth Section Abstract Doc Link 15636982 Disease Relevance 0.07 Pain Relevance 0.28
Both types of studies showed that epidural analgesia increased risk of oxytocin augmentation 2-fold.
Positive_regulation (increased) of Positive_regulation (augmentation) of oxytocin
10) Confidence 0.43 Published 1999 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 10203666 Disease Relevance 0 Pain Relevance 0
We conclude that: (i) continuous E2 infusion results in a pattern of uterine activity characterized by alternating high activity and quiescence, and increased frequency of occasional rises in basal IUP; (ii) E2 induced increases in OT and PGF2 alpha responses are consistent with other reports that E2 increases OT and PGF2 alpha binding to myometrium; (iii) the E2 effect on OT response is probably independent of enhanced PG synthesis.
Positive_regulation (induced) of Positive_regulation (increases) of OT in myometrium associated with dismenorea
11) Confidence 0.33 Published 1983 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 6311384 Disease Relevance 0.39 Pain Relevance 0.39

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