INT36777

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Context Info
Confidence 0.41
First Reported 1986
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 11.47
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
coronary artery 3
B-cell 1
HNP 1
CTD (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 6 99.50 Very High Very High Very High
fibrosis 2 98.28 Very High Very High Very High
Morphine 1 94.08 High High
cocaine 1 92.72 High High
Pain 15 92.64 High High
headache 4 90.88 High High
Sciatica 1 84.60 Quite High
Fibrositis 36 83.12 Quite High
Angina 2 79.92 Quite High
Inflammation 26 79.76 Quite High
Disease Link Frequency Relevance Heat
Disease 370 100.00 Very High Very High Very High
Cleidocranial Dysplasia 93 100.00 Very High Very High Very High
Watson Syndrome 90 100.00 Very High Very High Very High
Coronary Artery Disease 12 100.00 Very High Very High Very High
Stress 2 99.92 Very High Very High Very High
Acute Coronary Syndrome 2 99.76 Very High Very High Very High
Left Ventricular Hypertrophy 1 99.66 Very High Very High Very High
Systemic Lupus Erythematosus 69 99.48 Very High Very High Very High
Fibrosis 2 98.28 Very High Very High Very High
Nephrosclerosis 1 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In two cases CTD was positive for recurrent HNP but surgery showed only fibrosis.
Gene_expression (positive) of CTD in HNP associated with fibrosis
1) Confidence 0.41 Published 1988 Journal Neuroradiology Section Abstract Doc Link 3405411 Disease Relevance 0.32 Pain Relevance 0.17
Gene expression data are essentially present in the CTD such as a chemical can increase, decrease or affect a gene expression.
Gene_expression (present) of CTD
2) Confidence 0.33 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2873901 Disease Relevance 0.17 Pain Relevance 0
Different associations are presented in the CTD such as “chemical x results in increased expression of protein z” or “compound x binds to protein z”.
Gene_expression (presented) of CTD
3) Confidence 0.33 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2873901 Disease Relevance 0.18 Pain Relevance 0
However, only few binding data are present in CTD and therefore integrated in our network: 3189 in total among the 42,194 associations.
Gene_expression (present) of CTD
4) Confidence 0.33 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2873901 Disease Relevance 0.15 Pain Relevance 0
A total of five patients were diagnosed with CTD with two in the last 5 years.
Gene_expression (diagnosed) of CTD associated with disease
5) Confidence 0.32 Published 2008 Journal Clin. Rheumatol. Section Abstract Doc Link 18500432 Disease Relevance 0.82 Pain Relevance 0.09
There are five important research objectives of an NF1-CTD study that provide a context for applying the framework described in the Methods section:
Gene_expression (study) of CTD associated with cleidocranial dysplasia and watson syndrome
6) Confidence 0.28 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC548287 Disease Relevance 1.02 Pain Relevance 0.09
The prevalence of NF1-CTD is relatively low.
Gene_expression (prevalence) of CTD associated with cleidocranial dysplasia and watson syndrome
7) Confidence 0.28 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC548287 Disease Relevance 0.90 Pain Relevance 0.05
CTD is diagnosed usually during the first year of life and fractures often occur before 3 years of age.
Gene_expression (diagnosed) of CTD associated with cleidocranial dysplasia
8) Confidence 0.24 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC548287 Disease Relevance 1.76 Pain Relevance 0.09
The presence of previous coronary artery disease (CAD) is an exclusion criterion for this diagnosis in several studies.
Gene_expression (presence) of coronary artery disease in coronary artery associated with coronary artery disease
9) Confidence 0.19 Published 2008 Journal Int. J. Cardiol. Section Abstract Doc Link 18201780 Disease Relevance 0.84 Pain Relevance 0.08
Within the group of women with silicone implants and CTD (Group 1), between those women with paraproteins and those women without paraproteins there were only borderline significant differences or no significant differences (Mann–Whitney U test) in age (55.6 years versus 49.3 years, P = 0.041), in duration of CTD (10.4 versus 6.4 years, P = 0.051), in implant duration (10.2 years versus 12.5 years, P = 0.267), and in duration of silicone exposure (16.1 years versus 15.4 years, P = 0.783).
Gene_expression (duration) of CTD associated with disease
10) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212583 Disease Relevance 1.48 Pain Relevance 0.30
Although B-cell hyperreactivity and ANA production are characteristic hallmarks of CTD, especially SLE, serum ANAs are often found in subjects who do not fulfil the classification criteria for a CTD (22).
Gene_expression (hallmarks) of CTD in B-cell associated with systemic lupus erythematosus and disease
11) Confidence 0.10 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 1.39 Pain Relevance 0
Regardless of the presence or absence of CTD, there was a trend toward lower levels of total protein and various globulin fractions in women with silicone implants (Figure 1).
Neg (absence) Gene_expression (absence) of CTD associated with disease
12) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212583 Disease Relevance 0.74 Pain Relevance 0.12
Usefulness of oral dipyridamole suspension for stress thallium imaging without exercise in the detection of coronary artery disease.
Gene_expression (detection) of coronary artery disease in coronary artery associated with stress, coronary artery disease and imagery
13) Confidence 0.03 Published 1986 Journal Am. J. Cardiol. Section Title Doc Link 3953432 Disease Relevance 0.78 Pain Relevance 0.29
Left ventricular hypertrophy was common, and coronary artery disease (CAD) detected in nearly one third of the cases.
Gene_expression (detected) of coronary artery disease in coronary artery associated with coronary artery disease and left ventricular hypertrophy
14) Confidence 0.01 Published 2004 Journal Forensic Sci. Int. Section Abstract Doc Link 14687775 Disease Relevance 0.92 Pain Relevance 0.14

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