INT36778

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Context Info
Confidence 0.48
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 12.85
Pain Relevance 5.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
BLA 1
heart 1
Anxty (Mus musculus)
Pain Link Frequency Relevance Heat
depression 347 100.00 Very High Very High Very High
Kappa opioid receptor 100 99.92 Very High Very High Very High
Dynorphin 98 99.84 Very High Very High Very High
backache 5 99.74 Very High Very High Very High
headache 5 99.50 Very High Very High Very High
Fibrositis 3 99.44 Very High Very High Very High
amygdala 92 99.40 Very High Very High Very High
addiction 18 99.32 Very High Very High Very High
Lasting pain 9 98.96 Very High Very High Very High
Migraine 3 97.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 732 100.00 Very High Very High Very High
Depression 337 100.00 Very High Very High Very High
Low Back Pain 3 99.74 Very High Very High Very High
Headache 8 99.50 Very High Very High Very High
Sleep Disorders 5 99.44 Very High Very High Very High
Cognitive Disorder 122 99.32 Very High Very High Very High
Pain 122 98.96 Very High Very High Very High
Heart Rate Under Development 8 98.16 Very High Very High Very High
Neurological Disease 3 97.72 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 31 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For such a clinical decision, a decision aid would be expected to improve patient knowledge and create realistic expectations, to reduce decisional conflict and to stimulate patients to be more active in decision making without increasing anxiety [1].
Positive_regulation (increasing) of anxiety associated with anxiety disorder
1) Confidence 0.48 Published 2004 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC539301 Disease Relevance 0.74 Pain Relevance 0.97
Decision aids have been found to improve patient knowledge and create more realistic expectations, to reduce decisional conflict (uncertainty about the course of action) and to stimulate patients to be more active in decision making without increasing anxiety [1].
Positive_regulation (increasing) of anxiety associated with anxiety disorder and acquired immune deficiency syndrome or hiv infection
2) Confidence 0.48 Published 2004 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC539301 Disease Relevance 0.56 Pain Relevance 0
This increase is updated after every activation with AnxInc.
Positive_regulation (activation) of AnxInc
3) Confidence 0.47 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2792710 Disease Relevance 0.56 Pain Relevance 0.10
Values ranging from 0.001% to 10% for AnxInc and values from 0.05 to 0.15 for AnxIncFight, AnxDcrGree and AnxDcrGrmr (whereby AnxDcrGree was kept at higher values than AnxDcrGrmr) changed the level of anxiety, but did not change results qualitatively.
Positive_regulation (values) of AnxDcrGrmr associated with anxiety disorder
4) Confidence 0.41 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2792710 Disease Relevance 0.37 Pain Relevance 0
The simulation was run in turn 1) without the self-reinforcing effects of winning and losing fights, 2) without the grooming inducing effect of anxiety, 3) without the dependence of grooming on the risks to attack and 4) without the selection of interaction partners on the basis of spatial proximity.
Positive_regulation (inducing) of anxiety associated with addiction and anxiety disorder
5) Confidence 0.41 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2792710 Disease Relevance 0.47 Pain Relevance 0.05
Children with migraine revealed higher scores on all scales measuring depression and somatic complaints; adolescent headache sufferers also revealed increased levels of trait anxiety.
Positive_regulation (increased) of anxiety associated with depression, migraine, anxiety disorder and headache
6) Confidence 0.40 Published 1988 Journal Pain Section Abstract Doc Link 3405619 Disease Relevance 1.15 Pain Relevance 0.73
As to the order of what to do first, we are led by four observations: first, those on baboons by Kummer [56] who inform us that upon their first encounter individuals first fight and later groom; second, by the empirical finding that an individual builds up anxiety (as indicated by the increased heart rate) when approaching an opponent by whom it may be defeated [rhesus monkeys, 57]; third, that anxiety increases after a fight as is indicated by the increase in frequency of scratching and heart rate in both opponents [25], [58]–[64]; fourth, that anxiety may subsequently be reduced (in many species) by the receipt of affiliative behaviour as indicated by the reduced heart rate and the rate of self-directed behaviour [57],[61],[62],[64] and to a lesser degree by active grooming [65].
Positive_regulation (increases) of anxiety in heart associated with heart rate under development and anxiety disorder
7) Confidence 0.38 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2792710 Disease Relevance 0.39 Pain Relevance 0.06
Its anxiety also increases after a fight and after a period of not having been involved in grooming.
Positive_regulation (increases) of anxiety associated with anxiety disorder
8) Confidence 0.38 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2792710 Disease Relevance 0.55 Pain Relevance 0.06
Anxiety is induced by fighting and increases with the duration of not being groomed.
Positive_regulation (induced) of Anxiety associated with anxiety disorder
9) Confidence 0.38 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2792710 Disease Relevance 0.57 Pain Relevance 0
Screening procedures to detect patients with elevated anxiety and depression are important in rehabilitation settings to allow the identification of patients requiring additional psychological assessment, prior to commencement of programs.
Positive_regulation (elevated) of anxiety associated with depression and anxiety disorder
10) Confidence 0.04 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1343593 Disease Relevance 1.49 Pain Relevance 0.56
Previous reviews of prevalence rates [34] suggest that patients with chronic pain (including fibromyalgia, and back pain) had higher prevalence of anxiety and depression than patients with oncology, cardiac and neurological disorders.
Positive_regulation (prevalence) of anxiety associated with neurological disease, depression, lasting pain, anxiety disorder, fibrositis and backache
11) Confidence 0.04 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1343593 Disease Relevance 1.78 Pain Relevance 0.48
The total sample was used to identify the proportion of patients with elevated levels of anxiety and depression.
Positive_regulation (elevated) of anxiety associated with depression and anxiety disorder
12) Confidence 0.04 Published 2005 Journal Health Qual Life Outcomes Section Abstract Doc Link PMC1343593 Disease Relevance 1.37 Pain Relevance 0.42
Risks of functional disability, cognitive decline, and nursing home placement also increase with depression or anxiety (Lenze, Martire, et al 2001; Gibbons et al 2002; Sinoff and Werner 2003).
Positive_regulation (increase) of anxiety associated with cognitive disorder, depression and anxiety disorder
13) Confidence 0.03 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682453 Disease Relevance 2.07 Pain Relevance 0.48
These data corroborate other reports [22], [32] using similar assay conditions and strongly support a role for dynorphin/KOR in mediating anxiety-like behaviors.


Positive_regulation (mediating) of anxiety-like associated with dynorphin, anxiety disorder and kappa opioid receptor
14) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.42 Pain Relevance 0.51
The anxiogenic-like effects of CRF and stressin 1 suggest that CRF1-R receptor activation induces dynorphin release in the basolateral amygdala (BLA), a brain region regarded as necessary for anxiety-like behaviors [36].
Positive_regulation (necessary) of anxiety-like in BLA associated with dynorphin, anxiety disorder and amygdala
15) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.37 Pain Relevance 0.66

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