INT3679

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Context Info
Confidence 0.78
First Reported 1977
Last Reported 2010
Negated 4
Speculated 1
Reported most in Abstract
Documents 171
Total Number 172
Disease Relevance 72.90
Pain Relevance 35.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (AVP) cell-cell signaling (AVP) response to stress (AVP)
signal transducer activity (AVP) cytosol (AVP) extracellular space (AVP)
Anatomy Link Frequency
plasma 34
neurons 9
hypothalamus 6
skin 4
blood 3
AVP (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 657 100.00 Very High Very High Very High
Neurotransmitter 104 100.00 Very High Very High Very High
Dopamine 84 100.00 Very High Very High Very High
Enkephalin 77 100.00 Very High Very High Very High
Serotonin 91 99.92 Very High Very High Very High
bradykinin 31 99.92 Very High Very High Very High
Calcitonin gene-related peptide 3 99.92 Very High Very High Very High
opiate 42 99.90 Very High Very High Very High
narcan 51 99.86 Very High Very High Very High
Perioperative pain 12 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyponatremia 1085 100.00 Very High Very High Very High
Stress 189 100.00 Very High Very High Very High
Vomiting 144 100.00 Very High Very High Very High
Natriuresis 121 100.00 Very High Very High Very High
Syndrome 85 100.00 Very High Very High Very High
Cv General 2 Under Development 1316 99.84 Very High Very High Very High
Cv Unclassified Under Development 107 99.82 Very High Very High Very High
Adrenal Insufficiency 40 99.82 Very High Very High Very High
Post Operative Pain 12 99.78 Very High Very High Very High
Appetite Loss 11 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results suggest either that circulating AVP is taken up and accumulated by the human vas deferens, and/or that AVP is synthesized locally.
Gene_expression (synthesized) of AVP in vas deferens
1) Confidence 0.78 Published 1988 Journal J. Urol. Section Abstract Doc Link 3172359 Disease Relevance 0 Pain Relevance 0.27
With respect to the effect of estrogen on central neuropeptide transmission, estrogen stimulates the expression of the arginine vasopressin (AVP) gene in the bed nucleus of the stria terminalis (BNST) in rodents.
Gene_expression (expression) of AVP in nucleus associated with neuropeptide
2) Confidence 0.78 Published 1996 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 8818400 Disease Relevance 0.66 Pain Relevance 0.48
With respect to the effect of estrogen on central neuropeptide transmission, estrogen stimulates the expression of the arginine vasopressin (AVP) gene in the bed nucleus of the stria terminalis (BNST) in rodents.
Gene_expression (expression) of arginine vasopressin in nucleus associated with neuropeptide
3) Confidence 0.78 Published 1996 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 8818400 Disease Relevance 0.66 Pain Relevance 0.48
Should the infusion rate be titrated against MAP or AVP levels?
Gene_expression (levels) of AVP
4) Confidence 0.78 Published 2005 Journal Crit Care Section Body Doc Link PMC1175907 Disease Relevance 0.59 Pain Relevance 0.29
Structure and synthesis of vasopressin
Gene_expression (synthesis) of vasopressin
5) Confidence 0.78 Published 2005 Journal Crit Care Section Body Doc Link PMC1175907 Disease Relevance 0.46 Pain Relevance 0
At high concentrations it inhibits the production of vasopressin [50].
Gene_expression (production) of vasopressin
6) Confidence 0.78 Published 2005 Journal Crit Care Section Body Doc Link PMC1175907 Disease Relevance 0.66 Pain Relevance 0.48
Such a response to operation may produce ADH levels that can indeed decrease urinary flow, but more importantly may succeed in achieving levels that can exert a significant vasopressor effect.
Gene_expression (produce) of ADH associated with diuresis
7) Confidence 0.78 Published 1980 Journal Contemp Anesth Pract Section Abstract Doc Link 7011672 Disease Relevance 0.27 Pain Relevance 0.34
In addition, he developed SIADH-like symptoms, and we strongly suspected that it was due to ectopic production of ADH from this carcinoma.
Gene_expression (production) of ADH associated with hyponatremia and carcinoma
8) Confidence 0.78 Published 2004 Journal Nippon Hinyokika Gakkai Zasshi Section Abstract Doc Link 15354720 Disease Relevance 1.07 Pain Relevance 0.12
Levels of other anterior pituitary hormones (prolactin, luteinizing hormone and follicle stimulating hormone) and of arginine vasopressin were unchanged.
Gene_expression (Levels) of arginine vasopressin in follicle
9) Confidence 0.75 Published 1985 Journal J Hypertens Suppl Section Abstract Doc Link 3007707 Disease Relevance 0.63 Pain Relevance 0.89
Likewise, arginine vasopressin and oxytocin are expressed in the anterior hypothalamus.
Gene_expression (expressed) of arginine vasopressin in hypothalamus
10) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.41 Pain Relevance 0.18
The basic mechanism is straightforward: MDMA causes excess antidiuretic hormone (ADH) production and thus a reduced renal response to water loading, so that excess fluid ingestion following MDMA leads to dilutional hyponatraemia and cerebral oedema [18].
Gene_expression (production) of ADH associated with hyponatremia and pressure and volume under development
11) Confidence 0.75 Published 2008 Journal Crit Care Section Body Doc Link PMC2374627 Disease Relevance 1.99 Pain Relevance 0.62
A common cause of hyponatremia in patients with cancer is the syndrome of inappropriate secretion of antidiuretic hormone (SIADH), which may result from ectopic production of arginine vasopressin (AVP) by the tumor tissue.
Gene_expression (production) of arginine vasopressin associated with hyponatremia, syndrome and cancer
12) Confidence 0.75 Published 2007 Journal Support Care Cancer Section Abstract Doc Link 17701059 Disease Relevance 1.56 Pain Relevance 0.14
Blood samples were obtained by peripheral vein puncture before the induction of anesthesia, then 2, 4, 6, 8, 24, 48, and 72 h after skin incision to measure the levels of serum IL-6, adrenocorticotropic hormone (ACTH), cortisol, and antidiuretic hormone (ADH).
Gene_expression (levels) of ADH in skin associated with anesthesia
13) Confidence 0.75 Published 2000 Journal Surg. Today Section Abstract Doc Link 10664330 Disease Relevance 0.15 Pain Relevance 0.18
Most patients will produce a diuresis within hours as levels of MDMA fall and ADH production resumes.
Gene_expression (production) of ADH associated with diuresis
14) Confidence 0.75 Published 2008 Journal Crit Care Section Body Doc Link PMC2374627 Disease Relevance 1.73 Pain Relevance 0.51
Plasma levels of beta-endorphin, leucine enkephalin and arginine vasopressin in patients with essential hypertension and the effects of clonidine.
Gene_expression (levels) of arginine vasopressin in Plasma associated with hypertension, narcan, enkephalin and clonidine
15) Confidence 0.75 Published 1995 Journal Int. J. Cardiol. Section Title Doc Link 8586472 Disease Relevance 0.43 Pain Relevance 0.74
Pro-inflammatory cytokines, such as interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF alpha), released from inflammatory foci, can activate the hypothalamus to produce corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP).
Gene_expression (produce) of arginine vasopressin in hypothalamus associated with necrosis, inflammation, cancer and cytokine
16) Confidence 0.75 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11268412 Disease Relevance 0.97 Pain Relevance 0.57
Patients with obsessive-compulsive disorder (OCD) hypersecrete the arousal producing neurohormone arginine vasopressin (AVP) into the cerebrospinal fluid and plasma.
Gene_expression (producing) of AVP in plasma associated with obsessive-compulsive disorder and anxiety disorder
17) Confidence 0.75 Published 1992 Journal Brain Res. Section Abstract Doc Link 1450938 Disease Relevance 0.29 Pain Relevance 0.37
The resultant cell-volume shrinkage or increased intracellular osmolality, or both, in turn initiate a cascade of events that lead to the augmentation of both AVP synthesis and release (Robinson et al 1990).
Gene_expression (synthesis) of AVP
18) Confidence 0.71 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504060 Disease Relevance 0.13 Pain Relevance 0.14
The synthesis and release of AVP may also be induced by nonosmotic stimuli including hypovolemia, a fall in arterial blood pressure, neural regulation by various hypothalamic neurotransmitters and neuropeptides, and many pharmacological agents.
Gene_expression (synthesis) of AVP in neural associated with neurotransmitter, pressure volume 2 under development and neuropeptide
19) Confidence 0.71 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504060 Disease Relevance 0.31 Pain Relevance 0.38
In the dysregulated state where AVP is excessively produced and released irrespective of hypoosmolality, profound water retention and hyponatremia may occur (Baylis 2003).


Gene_expression (produced) of AVP associated with hyponatremia and pressure and volume under development
20) Confidence 0.71 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504060 Disease Relevance 0.59 Pain Relevance 0

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