INT36793

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Context Info
Confidence 0.40
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.51
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (KLKB1) extracellular space (KLKB1) extracellular region (KLKB1)
plasma membrane (KLKB1)
Anatomy Link Frequency
plasma 2
blood 1
KLKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 1 99.44 Very High Very High Very High
Inflammation 2 98.72 Very High Very High Very High
bradykinin 2 95.52 Very High Very High Very High
medulla 1 94.88 High High
Enkephalin 2 86.64 High High
antagonist 3 81.96 Quite High
metalloproteinase 3 47.20 Quite Low
addiction 3 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Restless leg syndrome 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eclampsia 3 95.24 Very High Very High Very High
Vasculitis 1 94.20 High High
Injury 1 88.48 High High
Leukemia 2 79.40 Quite High
Hereditary Angioedema 1 75.00 Quite High
Pressure Volume 2 Under Development 1 75.00 Quite High
Peripheral Arterial Disease 18 15.76 Low Low
Disease 7 5.00 Very Low Very Low Very Low
Coronary Artery Disease 6 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma kallikrein is also crosslinked to the coagulation system and the complement cascade.
Plasma kallikrein Binding (crosslinked) of in Plasma
1) Confidence 0.40 Published 2008 Journal Expert Opin Biol Ther Section Abstract Doc Link 18613770 Disease Relevance 0.15 Pain Relevance 0.24
All the identified cleavages occurred either COOH-terminal to or between pairs of basic amino acids, with plasma kallikrein recognizing Lys-Lys, Lys-Arg, and Arg-Arg as processing signals.
plasma kallikrein Binding (recognizing) of in plasma
2) Confidence 0.35 Published 1988 Journal J. Biol. Chem. Section Abstract Doc Link 3410851 Disease Relevance 0 Pain Relevance 0.13
Furthermore, our model currently has no blood sources of VEGF or sVEGFR1, which would elevate their respective plasma concentrations.
plasma Binding (concentrations) of in blood
3) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0.36 Pain Relevance 0.04

General Comments

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