INT36793

Context Info Confidence 0.40 First Reported 1988 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.51 Pain Relevance 0.42

peptidase activity (KLKB1) extracellular space (KLKB1) extracellular region (KLKB1) plasma membrane (KLKB1)

Anatomy Link Frequency plasma 2 blood 1 KLKB1 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 1 99.44 Inflammation 2 98.72 bradykinin 2 95.52 medulla 1 94.88 Enkephalin 2 86.64 antagonist 3 81.96 metalloproteinase 3 47.20 addiction 3 5.00 ischemia 2 5.00 Restless leg syndrome 1 5.00

Disease Link Frequency Relevance Heat Eclampsia 3 95.24 Vasculitis 1 94.20 Injury 1 88.48 Leukemia 2 79.40 Hereditary Angioedema 1 75.00 Pressure Volume 2 Under Development 1 75.00 Peripheral Arterial Disease 18 15.76 Disease 7 5.00 Coronary Artery Disease 6 5.00 Cancer 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Plasma kallikrein is also crosslinked to the coagulation system and the complement cascade.

Plasma kallikrein Binding (crosslinked) of in Plasma

1) Confidence 0.40 Published 2008 Journal Expert Opin Biol Ther Section Abstract Doc Link 18613770 Disease Relevance 0.15 Pain Relevance 0.24

All the identified cleavages occurred either COOH-terminal to or between pairs of basic amino acids, with plasma kallikrein recognizing Lys-Lys, Lys-Arg, and Arg-Arg as processing signals.

plasma kallikrein Binding (recognizing) of in plasma

2) Confidence 0.35 Published 1988 Journal J. Biol. Chem. Section Abstract Doc Link 3410851 Disease Relevance 0 Pain Relevance 0.13

Furthermore, our model currently has no blood sources of VEGF or sVEGFR1, which would elevate their respective plasma concentrations.

plasma Binding (concentrations) of in blood

3) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0.36 Pain Relevance 0.04

General Comments

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