INT36795

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Context Info
Confidence 0.78
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.05
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (KLKB1) extracellular space (KLKB1) extracellular region (KLKB1)
plasma membrane (KLKB1)
Anatomy Link Frequency
plasma 3
KLKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 2 100.00 Very High Very High Very High
bradykinin 8 99.96 Very High Very High Very High
medulla 1 91.16 High High
abdominal pain 6 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
headache 5 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Angioedema 22 92.76 High High
Hereditary Angioedema 57 92.12 High High
Disease 19 58.28 Quite High
Pressure And Volume Under Development 16 33.16 Quite Low
Death 3 28.00 Quite Low
Phobia 1 27.76 Quite Low
Emergencies 1 20.56 Low Low
Hypersensitivity 7 11.76 Low Low
Injury 3 11.68 Low Low
Stress 2 10.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since plasma kallikrein releases bradykinin from high-molecular-weight kininogen, its inhibition has also been a target of investigation[6].
Localization (releases) of plasma kallikrein in plasma associated with bradykinin
1) Confidence 0.78 Published 2010 Journal BMC Blood Disord Section Body Doc Link PMC2881905 Disease Relevance 1.05 Pain Relevance 0.12
Moreover, plasma kallikrein was found to cleave at the COOH terminus of the basic pairs of amino acids preceding enkephalin sequences thereby releasing the biologically active form of the peptide with the free NH2-terminal Tyr needed for receptor recognition.
Localization (releasing) of plasma kallikrein in plasma associated with enkephalin
2) Confidence 0.73 Published 1988 Journal J. Biol. Chem. Section Abstract Doc Link 3410851 Disease Relevance 0 Pain Relevance 0.15
Simultaneously in all fluid volumes, free VEGF121 levels remained consistent while free VEGF165, presumably released from NRP1s, elevated slightly (plasma data shown in Fig. 6E).
Localization (released) of plasma in plasma
3) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

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