INT36797

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.24
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 8.76
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Mki67) nucleolus (Mki67) nucleus (Mki67)
intracellular (Mki67) cytoplasm (Mki67)
Anatomy Link Frequency
vascular endothelium 1
Mki67 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 5 80.28 Quite High
headache 1 78.56 Quite High
Inflammation 22 75.52 Quite High
Pain 4 59.28 Quite High
Pyramidal cell 26 55.08 Quite High
Serotonin 12 53.08 Quite High
imagery 16 48.56 Quite Low
abdominal pain 6 42.16 Quite Low
Somatostatin 26 41.00 Quite Low
Hippocampus 10 37.68 Quite Low
Disease Link Frequency Relevance Heat
Cancer 583 99.84 Very High Very High Very High
Ovarian Cancer 74 99.84 Very High Very High Very High
Fibrosarcoma 54 99.80 Very High Very High Very High
Breast Cancer 383 97.64 Very High Very High Very High
Fibroma 10 97.24 Very High Very High Very High
Colon Cancer 3 96.00 Very High Very High Very High
Retinoblastoma 2 95.56 Very High Very High Very High
Osteogenic Sarcomas 60 95.40 Very High Very High Very High
Metastasis 69 93.68 High High
Lymphatic System Cancer 7 90.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For a subset of cases, the Ki-67 (MIB-1) proliferation index values were also available, and included values of < 10% for 5 cases, ?
Regulation (available) of Ki-67
1) Confidence 0.24 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2984427 Disease Relevance 0.61 Pain Relevance 0.04
Ki-67 immunoreactivity was assessed independently by two pathologists using a semi-quantitative method.
Regulation (immunoreactivity) of Ki-67
2) Confidence 0.24 Published 1988 Journal J. Pathol. Section Abstract Doc Link 3411382 Disease Relevance 0.37 Pain Relevance 0
Conversely, cell-cycle inhibitor p27KIP1 was strongly down-regulated, while markers like Ki67 and cdk2 were hardly affected by tau-mediated neurodegeneration (Figure 8A; results not shown).
Regulation (affected) of Ki67
3) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 0.30 Pain Relevance 0.03
Ki67 is vital for cell proliferation, since downregulation of Ki67 using antisense nucleotides prevents cell proliferation.10 Ki67 is tightly controlled and regulated, implying a fundamental role in cell proliferation.
Regulation (regulated) of Ki67
4) Confidence 0.18 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.67 Pain Relevance 0
Ki67 is vital for cell proliferation, since downregulation of Ki67 using antisense nucleotides prevents cell proliferation.10 Ki67 is tightly controlled and regulated, implying a fundamental role in cell proliferation.
Regulation (controlled) of Ki67
5) Confidence 0.18 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.67 Pain Relevance 0
This Phase II double-blind, randomised, multicentre study compared the effects of a single 250mg intramuscular dose of fulvestrant and placebo 14-21 days prior to surgery of curative intent on the oestrogen receptor (ER), progesterone receptor and Ki67 levels in 66 premenopausal women with ER-positive primary breast cancer.
Regulation (effects) of Ki67 associated with breast cancer
6) Confidence 0.14 Published 2007 Journal Eur. J. Cancer Section Abstract Doc Link 17064888 Disease Relevance 0.48 Pain Relevance 0.08
There is a trend towards change noted in these markers (in this study, Ki-67, Bcl-2, Caspase-3) both at 24 hours and at 21 days after the first cycle of chemotherapy, although these results need to be confirmed in larger studies.
Regulation (change) of Ki-67
7) Confidence 0.13 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2669088 Disease Relevance 0.32 Pain Relevance 0.06
In work by Tsuji et al. [3], the Ki-67 index values for fibrosarcomas were found to be higher than the Ki-67 values for fibromas.
Regulation (values) of Ki-67 associated with fibroma and fibrosarcoma
8) Confidence 0.13 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2984427 Disease Relevance 1.15 Pain Relevance 0
This review summarizes mainly the prognostic values of classical (Ki67, ER, PR, HER2) and novel molecular factors (p53, p14ARF, cyclin D1, cyclin E, TBX2/3, BRCA1/2, and VEGF) for breast cancer.
Regulation (values) of Ki67 associated with breast cancer
9) Confidence 0.12 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.18 Pain Relevance 0
The study also found significant associations between EGFR and Ki-67 (p = 0.002), EGFR and p-AKT (p = 0.027), and p-AKT and Ki-67 controlling EGFR (p = 0.004).
Regulation (controlling) of Ki-67
10) Confidence 0.10 Published 2007 Journal Biomarker Insights Section Abstract Doc Link PMC2717822 Disease Relevance 0.46 Pain Relevance 0
In addition, no reports are available on the correlation pattern among EGFR, AKT, and Ki-67, a cancer cell proliferation index.
Regulation (available) of Ki-67 associated with cancer
11) Confidence 0.10 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717822 Disease Relevance 0.68 Pain Relevance 0
Chromogranin A appears to undergo a process of fragmentation, and the fragments detected by particular tests influence the resulting sensitivity.

4.3 Ki67

Regulation (influence) of Ki67
12) Confidence 0.09 Published 2006 Journal Current Oncology Section Body Doc Link PMC1891174 Disease Relevance 0.48 Pain Relevance 0.06
The vascular endothelium was an internal positive control for CD34, and small intestine mucosa was an internal control for Ki-67.
Regulation (control) of Ki-67 in vascular endothelium
13) Confidence 0.07 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1633731 Disease Relevance 0.97 Pain Relevance 0.03
Another example is Ki-67; there are conflicting results on the prognostic value of Ki-67 in ovarian carcinoma [31–36].
Regulation (value) of Ki-67 associated with ovarian cancer
14) Confidence 0.03 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2592352 Disease Relevance 0.41 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox