INT36798

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Context Info
Confidence 0.77
First Reported 1988
Last Reported 2010
Negated 8
Speculated 8
Reported most in Body
Documents 178
Total Number 187
Disease Relevance 132.00
Pain Relevance 8.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Mki67) nucleolus (Mki67) nucleus (Mki67)
intracellular (Mki67) cytoplasm (Mki67)
Anatomy Link Frequency
brain 3
smooth muscle 2
endometrium 2
liver 2
pancreas 2
Mki67 (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 163 100.00 Very High Very High Very High
Dismenorea 19 99.84 Very High Very High Very High
Chronic pancreatitis 18 99.20 Very High Very High Very High
Inflammation 231 97.56 Very High Very High Very High
cINOD 26 96.28 Very High Very High Very High
cytokine 101 95.56 Very High Very High Very High
fifth nerve 8 95.52 Very High Very High Very High
positron emission tomography 429 94.32 High High
headache 16 92.20 High High
Pain 48 90.72 High High
Disease Link Frequency Relevance Heat
Ovarian Cancer 653 100.00 Very High Very High Very High
Apoptosis 633 100.00 Very High Very High Very High
Malignant Neoplastic Disease 392 100.00 Very High Very High Very High
Hyperplasia 229 100.00 Very High Very High Very High
Epstein-barr Virus 94 100.00 Very High Very High Very High
Breast Cancer 1909 99.98 Very High Very High Very High
Uterine Fibroids 200 99.98 Very High Very High Very High
Body Weight 34 99.96 Very High Very High Very High
Necrosis 89 99.88 Very High Very High Very High
Cancer 6594 99.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immuno-histochemical study of Ki-67 antigen expression was also performed with a labelling index of 10%.
Gene_expression (expression) of Ki-67
1) Confidence 0.77 Published 2006 Journal J Neurosurg Sci Section Abstract Doc Link 17108889 Disease Relevance 0.63 Pain Relevance 0.24
The immunohistochemical analysis of the expression of Ki-67 and Cyclin B1 proteins (cellular proliferation markers) revealed a very low proliferative cell index.
Gene_expression (expression) of Ki-67 associated with hyperplasia
2) Confidence 0.76 Published 2009 Journal J Orofac Pain Section Abstract Doc Link 19639107 Disease Relevance 1.52 Pain Relevance 0.49
The correlation between Ki67 gene expression and 18F-FLT uptake in our study is in accordance with other studies finding strong correlation between Ki67 at the protein level and 18F-FLT uptake [8]–[11].
Gene_expression (expression) of Ki67 gene
3) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0.06 Pain Relevance 0.03
Expression of Ki67 and TK1
Gene_expression (Expression) of Ki67
4) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0 Pain Relevance 0
Comparison of 18F-FLT uptake and Ki67 gene expression showed a similar change following treatment with Top216.
Gene_expression (expression) of Ki67 gene
5) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0.13 Pain Relevance 0.07
This was further validated by a similar decrease in Ki67 gene expression.
Gene_expression (expression) of Ki67 gene
6) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0.63 Pain Relevance 0.04
Expression of Ki67 and TK1 was analyzed in vitro in a parallel group of mice, which were treated with either Top216 or vehicle and biopsied before and at 6, 30 (Day 1) and 126 (Day 5) hours after initiation of treatment.
Spec (analyzed) Gene_expression (Expression) of Ki67
7) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0.52 Pain Relevance 0
Gene expression levels of Ki67 and TK1 are shown in figure 6.
Gene_expression (expression) of Ki67
8) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0 Pain Relevance 0
Uptake of 18F-FLT was compared with uptake of 18F-FDG and Ki67 and TK1 gene expression.


Gene_expression (expression) of Ki67
9) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0.71 Pain Relevance 0.09
Cryostat sections from samples of 108 colorectal carcinomas were stained with the murine monoclonal antibody Ki-67, which is expressed in proliferating cells.
Gene_expression (expressed) of monoclonal antibody Ki-67 associated with colon cancer
10) Confidence 0.68 Published 1988 Journal J. Pathol. Section Abstract Doc Link 3411382 Disease Relevance 0.36 Pain Relevance 0
Tumour biology characterised by Ki67 and E-cadherin expression may help to identify patients with a favourable outcome so that patient selection can be improved, but this needs further evaluation in larger patient cohorts.
Gene_expression (expression) of Ki67 associated with cancer
11) Confidence 0.65 Published 2005 Journal Best Pract Res Clin Gastroenterol Section Abstract Doc Link 16183532 Disease Relevance 0.89 Pain Relevance 0.17
All antigens used here including c-Kit, CD34, vimentin, smooth muscle actin (SMA), desmin, S100 protein, synaptophysin, CD56 and Ki67 (MIB-1) were summarized in Table 2.
Gene_expression (used) of Ki67 in smooth muscle
12) Confidence 0.65 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2822305 Disease Relevance 0.83 Pain Relevance 0.06
Expression of Ki67 was 21% increased at Day 5 (P?
Gene_expression (Expression) of Ki67
13) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0 Pain Relevance 0.03
In the treatment group expression of Ki67 was significantly lower at 6 hours post injection (?
Gene_expression (expression) of Ki67
14) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0 Pain Relevance 0
Expression of Ki67 in the control group was significantly lower at 6 hours (?
Gene_expression (Expression) of Ki67
15) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0 Pain Relevance 0.03
The survival rate and the correlation between Ki67 expression and each factor were assessed using the Kaplan-Meier method and the log-rank test using the SPSS software (SPSS Inc., Chicago, IL, USA).
Gene_expression (expression) of Ki67
16) Confidence 0.59 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671769 Disease Relevance 0.80 Pain Relevance 0
From 1995 to 2007, 27 patients with sinonasal mucosal melanoma were reviewed retrospectively, and the expression of Ki67 antigen was assessed by immunohistochemistry.


Gene_expression (expression) of Ki67 associated with melanoma
17) Confidence 0.59 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Abstract Doc Link PMC2671769 Disease Relevance 0.52 Pain Relevance 0
Melanin staining was detected in the cytoplasm, whereas Ki67 was detected in the nuclei of tumor cells.
Gene_expression (detected) of Ki67 associated with cancer
18) Confidence 0.59 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671769 Disease Relevance 0.39 Pain Relevance 0
Thus, our primary objectives were to analyze the clinical features of sinonasal MMM and to determine whether Ki67 expression is correlated with prognosis.


Spec (whether) Gene_expression (expression) of Ki67 associated with melanoma
19) Confidence 0.59 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671769 Disease Relevance 1.22 Pain Relevance 0
Immunohistochemistry revealed a strong positivity for the Ki67-antigen (Figure 3); the Ki67 index was between 41% and 48%, respectively

Intraperitoneal Tumours

Gene_expression (index) of Ki67 associated with cancer
20) Confidence 0.57 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527616 Disease Relevance 0.67 Pain Relevance 0

General Comments

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