INT36799

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Context Info
Confidence 0.41
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 17.47
Pain Relevance 3.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ighm)
Anatomy Link Frequency
egg 3
B cells 2
bone marrow 2
lymphoid tissues 2
Ighm (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 23 99.12 Very High Very High Very High
Morphine 8 98.56 Very High Very High Very High
analgesia 10 98.20 Very High Very High Very High
tolerance 6 95.64 Very High Very High Very High
Buprenorphine 4 95.08 Very High Very High Very High
abdominal pain 19 92.60 High High
Pain management 2 92.40 High High
Opioid 2 91.72 High High
Multiple sclerosis 27 90.48 High High
Spinal cord 38 88.56 High High
Disease Link Frequency Relevance Heat
Splenic Rupture 52 99.52 Very High Very High Very High
Neuromyelitis Optica 272 99.32 Very High Very High Very High
Hypersensitivity 6 98.76 Very High Very High Very High
Immunization 77 98.68 Very High Very High Very High
Anaphylaxis 6 98.60 Very High Very High Very High
Cancer 69 98.20 Very High Very High Very High
Disease 186 96.20 Very High Very High Very High
Anaerobic Bacterial Infections 16 95.36 Very High Very High Very High
Peripheral Neuropathy 4 94.56 High High
Lymphatic System Cancer 68 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In 3 out of 4 mice treated with PZQ, only IgM antibody to egg antigen was drastically declined from 30 min to 6 hr after treatment, and then gradually rose to the initial level after 2 to 3 days.
Negative_regulation (declined) of IgM in egg
1) Confidence 0.41 Published 1988 Journal Jpn. J. Exp. Med. Section Abstract Doc Link 3411793 Disease Relevance 0.16 Pain Relevance 0
By the inhibition ELISA, the amount of circulating immune complex (CIC) in serum was shown to be correlated with increase in amount of egg antigen and with decrease in titers of anti-egg IgM.
Negative_regulation (decrease) of IgM in egg
2) Confidence 0.41 Published 1988 Journal Jpn. J. Exp. Med. Section Abstract Doc Link 3411793 Disease Relevance 0.16 Pain Relevance 0.07
In 2 infected mice intravenously injected with 1.5 mg of egg antigen only anti-egg IgM was remarkably reduced shortly after injection and fatal anaphylactic reactions occurred after 30 or 60 min.
Negative_regulation (reduced) of IgM in egg associated with anaphylaxis
3) Confidence 0.41 Published 1988 Journal Jpn. J. Exp. Med. Section Abstract Doc Link 3411793 Disease Relevance 0.18 Pain Relevance 0.05
10) of all IgM positive vaccinees, a decline of the IgM titre was observed while the IgG titre was constant until the last analysis.
Negative_regulation (decline) of IgM
4) Confidence 0.28 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2982812 Disease Relevance 0 Pain Relevance 0
However, in synovia containing lymphoid aggregates, substantial and significant reductions of total IgM and IgG were noted in response to rituximab, whether assayed by constant region mRNA levels (Figure 7a) or by protein content (Figure 7b).
Negative_regulation (reductions) of IgM
5) Confidence 0.24 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.23 Pain Relevance 0.03
A small but significant reduction in circulating RF-IgM, anti-CCP IgG, and total IgM, but not total IgG, was observed (Figure 6a).
Negative_regulation (reduction) of IgM
6) Confidence 0.24 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.06 Pain Relevance 0
Two-way ANOVA showed no significant effect of cathepsin D deficiency on IgM, IgG1 or IgG2b (P > 0.05).
Negative_regulation (deficiency) of IgM
7) Confidence 0.22 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2048983 Disease Relevance 0.27 Pain Relevance 0
Mice were allowed to recover for 21–29 d after surgery, at which time the total serum IgM was determined to be equivalent between the sham-operated and splenectomized groups.
Negative_regulation (equivalent) of IgM
8) Confidence 0.22 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.24 Pain Relevance 0.35
Although a similar reduction in NP-specific IgM was not observed at day 7 after immunization, this time point coincided with the return of MZ B cells to the spleen after integrin treatment and MZ B cell depletion (Fig.
Negative_regulation (reduction) of IgM in B cells associated with immunization
9) Confidence 0.22 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.28 Pain Relevance 0
As seen in BMMSC transplantation, SHED transplantation resulted in a significant reduction in serum levels of anti-dsDNA IgG and IgM, and ANA antibodies (Figures 4B-D).
Negative_regulation (reduction) of IgM
10) Confidence 0.19 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0.98 Pain Relevance 0
Significantly higher levels of antigen-specific IgM and significantly decreased antigen-specific delayed-type hypersensitivity responses were shown in apoE-deficient mice after immunization with tetanus toxoid as compared with control C57BL/6 mice [49].
Negative_regulation (decreased) of IgM associated with immunization, hypersensitivity and anaerobic bacterial infections
11) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.45 Pain Relevance 0.03
However, in aggregate-containing tissues, rituximab significantly reduced total IgM and IgG SSI as well as IgM and IgG1 mRNA.
Negative_regulation (reduced) of IgM
12) Confidence 0.11 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2592782 Disease Relevance 0.66 Pain Relevance 0.33
Consistent with the potential role of a humoral response in NMO pathogenesis is the perivascular deposition of IgM and IgG, both of unknown specificity.
Negative_regulation (deposition) of IgM associated with neuromyelitis optica
13) Confidence 0.07 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.87 Pain Relevance 0.11
Neuropathologic studies demonstrate that NMO is characterized by distinctive “vasculocentric” pathology with prominent perivascular immunoglobulin deposition (IgG and IgM) and evidence of activation of complement lytic pathway, invoking B cell participation in the disease process [56, 100].
Negative_regulation (deposition) of IgM in B cell associated with neuromyelitis optica and disease
14) Confidence 0.07 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 2.71 Pain Relevance 0.40
The immunogenicity of NGcGM3/VSSP was confirmed, with all evaluable patients eliciting IgM and IgG responses after treatment.
Negative_regulation (eliciting) of IgM
15) Confidence 0.06 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2965427 Disease Relevance 0.76 Pain Relevance 0
These symptoms reflect tumour infiltration of lymphoid tissues and bone marrow, increased serum immunoglobulin, tissue deposition of IgM, and auto-antibody activity of IgM [1].
Negative_regulation (deposition) of IgM in bone marrow associated with cancer
16) Confidence 0.04 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2944189 Disease Relevance 2.35 Pain Relevance 0.15
These symptoms reflect tumour infiltration of lymphoid tissues and bone marrow, increased serum immunoglobulin, tissue deposition of IgM, and auto-antibody activity of IgM [1].
Negative_regulation (deposition) of IgM in bone marrow associated with cancer
17) Confidence 0.04 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2944189 Disease Relevance 2.38 Pain Relevance 0.15
These symptoms reflect tumour infiltration of lymphoid tissues and bone marrow, increased serum immunoglobulin, tissue deposition of IgM, and auto-antibody activity of IgM [1].
Negative_regulation (deposition) of IgM in lymphoid tissues associated with cancer
18) Confidence 0.01 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2944189 Disease Relevance 2.38 Pain Relevance 0.15
These symptoms reflect tumour infiltration of lymphoid tissues and bone marrow, increased serum immunoglobulin, tissue deposition of IgM, and auto-antibody activity of IgM [1].
Negative_regulation (deposition) of IgM in lymphoid tissues associated with cancer
19) Confidence 0.01 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2944189 Disease Relevance 2.35 Pain Relevance 0.15
Taken together, these results suggest that PKCI functions as a negative regulator in HmuOR desensitization, phosphorylation, and in mediating morphine analgesia.
Negative_regulation (desensitization) of HmuOR associated with analgesia and morphine
20) Confidence 0.00 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15496510 Disease Relevance 0 Pain Relevance 1.01

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