INT3682

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Context Info
Confidence 0.42
First Reported 1977
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 1.87
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 8
erythrocytes 1
urine 1
Ppr1 (Mus musculus)
Pain Link Frequency Relevance Heat
methadone 6 99.72 Very High Very High Very High
Gabapentin 103 99.26 Very High Very High Very High
Neuropeptide 9 98.80 Very High Very High Very High
bradykinin 1 96.52 Very High Very High Very High
addiction 1 95.36 Very High Very High Very High
Inflammatory mediators 1 95.20 Very High Very High Very High
Bioavailability 9 94.24 High High
qutenza 1 93.00 High High
Neurotransmitter 2 87.52 High High
Central nervous system 46 85.96 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 3 99.40 Very High Very High Very High
INFLAMMATION 6 94.80 High High
Pain 5 81.96 Quite High
Ganglion Cysts 46 77.68 Quite High
Body Weight 4 77.12 Quite High
Schizophrenia 13 75.00 Quite High
Psychosis 7 75.00 Quite High
Neuropathic Pain 28 74.40 Quite High
Adverse Drug Reaction 1 71.48 Quite High
Neuralgia 2 68.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Covalent binding of ibuprofen to plasma protein was observed in all patients, correlating well with the area under the plasma concentration versus time curve of ibuprofen glucuronide (r = 0.966).
plasma protein Binding (binding) of in plasma
1) Confidence 0.42 Published 1995 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 7781263 Disease Relevance 0.22 Pain Relevance 0.16
In canine and feline plasma the degree of binding of robenacoxib to plasma protein in vitro was greater than 98%.
plasma protein Binding (binding) of in plasma
2) Confidence 0.35 Published 2009 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 19161454 Disease Relevance 0.05 Pain Relevance 0.11
In the blood, drugs are present in the unbound form but may also be bound to plasma proteins and erythrocytes.
plasma protein Binding (bound) of in erythrocytes
3) Confidence 0.35 Published 2007 Journal Pharm Res Section Body Doc Link PMC2469271 Disease Relevance 0 Pain Relevance 0
Pardridge suggested that “the BBB PS product predicts the level of free drug in brain, because the level of free drug is determined by: (i) the total drug concentration in plasma; (ii) the PS product; and (iii), in the case of drugs bound by plasma proteins, the fraction of drug in plasma that is bioavailable for transport into brain.” (15).
plasma protein Binding (bound) of in plasma
4) Confidence 0.35 Published 2007 Journal Pharm Res Section Body Doc Link PMC2469271 Disease Relevance 0 Pain Relevance 0.07
Plasma protein binding, 85% on average, with extremes ranging from 79% to 89% did not depend on thiopentone concentration or age.
Plasma protein Binding (binding) of in Plasma
5) Confidence 0.28 Published 1986 Journal Anasth Intensivther Notfallmed Section Abstract Doc Link 3752425 Disease Relevance 0.22 Pain Relevance 0.07
Gabapentin is well absorbed orally, circulates unbound to plasma protein and it is excreted mostly in an unaltered form into urine [13].
plasma protein Binding (unbound) of in urine associated with gabapentin
6) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009974 Disease Relevance 0.81 Pain Relevance 1.09
The major factors are enzyme activity, plasma protein and blood cell binding, and gastrointestinal motility.
plasma protein Binding (binding) of in plasma
7) Confidence 0.04 Published 1984 Journal Clin Pharmacokinet Section Abstract Doc Link 6362950 Disease Relevance 0 Pain Relevance 0.24
The sensory neuropeptides cause not only vasodilatation but also, in some instances, extravasation of plasma protein and an increase in interstitial fluid volume.
plasma protein Binding (extravasation) of in plasma associated with neuropeptide and increased venous pressure under development
8) Confidence 0.01 Published 1990 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 2196862 Disease Relevance 0.31 Pain Relevance 0.68
Aripiprazole has extensive extravascular distribution and more than 99% of aripiprazole and dehydro-aripiprazole (the main active metabolite of aripiprazole) is bound to plasma protein.
plasma protein Binding (bound) of in plasma
9) Confidence 0.00 Published 2004 Journal Drugs Section Abstract Doc Link 15257633 Disease Relevance 0.26 Pain Relevance 0.24
Both methadone and LAAM may compete for plasma protein or tissue binding sites.
plasma protein Binding (compete) of in plasma associated with methadone
10) Confidence 0.00 Published 1977 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 832446 Disease Relevance 0 Pain Relevance 0.31

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