INT36835

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Context Info
Confidence 0.27
First Reported 1981
Last Reported 2008
Negated 3
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.85
Pain Relevance 2.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ctsa) nucleolus (Ctsa) nucleus (Ctsa)
molecular_function (Ctsa) cellular_component (Ctsa) biological_process (Ctsa)
Anatomy Link Frequency
muscle 1
Ctsa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nociceptor 3 100.00 Very High Very High Very High
Lasting pain 8 99.68 Very High Very High Very High
Hyperalgesia 9 99.36 Very High Very High Very High
cINOD 5 99.16 Very High Very High Very High
Potency 2 98.16 Very High Very High Very High
rheumatoid arthritis 4 94.08 High High
Peripheral nerve injury 3 91.40 High High
anesthesia 1 91.20 High High
aspirin 3 87.52 High High
Spinal cord 38 85.04 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 38 99.84 Very High Very High Very High
Diabetes Mellitus 6 99.40 Very High Very High Very High
Hyperalgesia 10 99.36 Very High Very High Very High
Pain 28 99.24 Very High Very High Very High
Nervous System Injury 4 90.96 High High
Autolysis 1 89.20 High High
Injury 10 87.08 High High
Disease 8 85.84 High High
Motor Neuron Diseases 2 84.24 Quite High
Rheumatoid Arthritis 4 83.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, all NSAID tested, except for SA, had no inhibitory effect on cathepsin E.
Neg (no) Regulation (effect) of cathepsin E associated with cinod
1) Confidence 0.27 Published 1988 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 3417210 Disease Relevance 0.14 Pain Relevance 0.44
In fact there is recent evidence in favor of the idea that the cathepsin inhibitors are also regulated during persistent pain states [36].
Regulation (regulated) of cathepsin associated with pain and lasting pain
2) Confidence 0.26 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2527007 Disease Relevance 0.84 Pain Relevance 0.62
There were no significant changes in lysosomal cathepsin activities in diabetic muscle as compared to controls.
Neg (no) Regulation (changes) of cathepsin in muscle associated with diabetes mellitus
3) Confidence 0.13 Published 1981 Journal Am. J. Physiol. Section Abstract Doc Link 7030084 Disease Relevance 0.54 Pain Relevance 0.09
This apparent contradiction might be explained by either an increase of the active form of CATX, that is still below the detection level of the Western Blot, or a concomitant regulation of endogenous cathepsin inhibitors, the cystatins or thyropins [34,35].
Regulation (regulation) of cathepsin
4) Confidence 0.11 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2527007 Disease Relevance 0.78 Pain Relevance 0.58
Role of the cysteine protease cathepsin S in neuropathic hyperalgesia.
Regulation (Role) of cathepsin S associated with hyperalgesia, nociceptor and neuropathic pain
5) Confidence 0.09 Published 2007 Journal Pain Section Title Doc Link 17250968 Disease Relevance 0.90 Pain Relevance 0.76
Chloroquine, a lysosomotropic agent of lower clinical potency than gold derivatives, inhibits neutral pH-labile cathepsins intracellularly, but does not affect the neutral pH-stable cathepsin S.
Neg (not) Regulation (affect) of cathepsin associated with potency
6) Confidence 0.03 Published 2007 Journal Biol. Chem. Section Abstract Doc Link 17338641 Disease Relevance 0.65 Pain Relevance 0.38

General Comments

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