INT36855

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Context Info
Confidence 0.42
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 6.16
Pain Relevance 4.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2RY6) signal transducer activity (P2RY6)
Anatomy Link Frequency
nasal 2
1321N1 2
T-cells 2
internal anal sphincter 1
monocytes 1
P2RY6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 236 99.42 Very High Very High Very High
antagonist 152 99.42 Very High Very High Very High
adenocard 108 99.32 Very High Very High Very High
cytokine 510 98.92 Very High Very High Very High
agonist 208 98.08 Very High Very High Very High
chemokine 32 96.96 Very High Very High Very High
Serotonin 4 90.68 High High
fibrosis 8 88.56 High High
imagery 12 86.80 High High
metalloproteinase 8 83.92 Quite High
Disease Link Frequency Relevance Heat
Anaplastic Astrocytoma 6 99.72 Very High Very High Very High
INFLAMMATION 236 99.42 Very High Very High Very High
Stress 71 98.66 Very High Very High Very High
Inflammatory Bowel Disease 14 98.38 Very High Very High Very High
Hypertension 96 95.12 Very High Very High Very High
Increased Venous Pressure Under Development 244 94.96 High High
Nociception 43 94.80 High High
Disease 132 94.08 High High
Diabetes Mellitus 44 93.20 High High
Neointima 20 89.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pyrimidinergic receptor P2Y6 (p2ry6) is expressed in human nasal epithelial cells and activates the IP3 signaling pathway in the presence of UDP, and regulates mucin and fluid secretion [49].
Gene_expression (expressed) of Pyrimidinergic receptor P2Y6 in nasal
1) Confidence 0.42 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2556351 Disease Relevance 0.22 Pain Relevance 0.12
Pyrimidinergic receptor P2Y6 (p2ry6) is expressed in human nasal epithelial cells and activates the IP3 signaling pathway in the presence of UDP, and regulates mucin and fluid secretion [49].
Gene_expression (expressed) of p2ry6 in nasal
2) Confidence 0.42 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2556351 Disease Relevance 0.22 Pain Relevance 0.12
In intact human blood vessels examined in vitro, shear stress decreased contractile P2X1 receptor expression, but increased the expression of mitogenic P2Y2 and P2Y6 receptors in VSMC [151].
Gene_expression (expression) of P2Y6 in blood vessels associated with stress
3) Confidence 0.39 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.48 Pain Relevance 0.03
Growth factors, cytokines and interestingly also ATP are potent stimulators of P2Y2 receptor expression [146, 147].
Gene_expression (expression) of P2Y2 receptor associated with cytokine
4) Confidence 0.39 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.55 Pain Relevance 0.05
1321N1 human astrocytoma cells stably expressing the human P2Y1, P2Y2, P2Y4, and P2Y6 receptors were grown in DMEM containing 4.5 g/l glucose, 5% fetal bovine serum and 600 µg/ml G-418.
Gene_expression (expressing) of P2Y6 in 1321N1 associated with anaplastic astrocytoma
5) Confidence 0.38 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096529 Disease Relevance 0.39 Pain Relevance 0.07
Based on the pharmacologic profiles, multiple purinergic receptors, including P2Y2, P2Y6, and P1 receptors, were functionally expressed.
Gene_expression (expressed) of P2Y6
6) Confidence 0.37 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Abstract Doc Link PMC2671790 Disease Relevance 0.47 Pain Relevance 0.32
It is therefore interesting that the human P2Y2 receptor contains an integrin-binding domain (RGD) in its first extracellular loop and that interaction with integrins influences P2Y2 receptor-mediated activation of G proteins [132].
Gene_expression (contains) of P2Y2 receptor
7) Confidence 0.34 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.68 Pain Relevance 0.07
The P2Y2 receptor is the most abundantly expressed receptor with very low levels of the P2Y4 receptor in the human heart [161], suggesting that the inotropic effects of UTP are mediated via P2Y2 receptors, while the UDP effects are mediated via the P2Y6 receptor [161].
Gene_expression (expressed) of P2Y2 receptor in heart
8) Confidence 0.34 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.13 Pain Relevance 0.17
Dulbecco's modified Eagle's medium (DMEM), fetal bovine serum G-418, and other cell culture reagents were obtained from the Tissue Culture Facility at the University of North Carolina, or from Gibco-BRL Life Technologies (Rockville, MD). 1321N1 human astrocytoma cells stably expressing the P2Y1, P2Y2, P2Y4, or P2Y6 receptors, and wild-type 1321N1 cell were obtained from the University of North Carolina at Chapel Hill.


Gene_expression (expressing) of P2Y6 in 1321N1 associated with anaplastic astrocytoma
9) Confidence 0.33 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096529 Disease Relevance 0.41 Pain Relevance 0.10
As such, P2Y6 receptor expression on T-cells may be upregulated at sites of inflammation and/or T-cells expressing this receptor may be preferentially recruited to these sites.
Gene_expression (expression) of P2Y6 in T-cells associated with inflammation
10) Confidence 0.31 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.53 Pain Relevance 0.43
However, tissue sections obtained from patients with inflammatory bowel disease are reported to contain T-cells within inflammatory lesions possessing enhanced expression of the P2Y6 receptor [51].
Gene_expression (expression) of P2Y6 in T-cells associated with inflammation
11) Confidence 0.31 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.53 Pain Relevance 0.43
The identity of the nucleobases in these dinucleotides was not responsible for the presence or lack of activity except for the necessity of adenosine for P2Y1 agonism and uridine for P2Y6 agonism.
Gene_expression (agonism) of P2Y6 associated with adenocard
12) Confidence 0.28 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096529 Disease Relevance 0 Pain Relevance 0.37
Circulating human neutrophils express P2Y4 and P2Y6 mRNAs, and the P2X7 receptor is reported to be present in these cells [22].
Gene_expression (express) of P2Y6 in neutrophils
13) Confidence 0.27 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.07 Pain Relevance 0.13
Human monocytes, for example, express mRNA encoding P2Y1, P2Y2, P2Y4, P2Y6, P2X1 and P2X7 receptors [14–16].
Gene_expression (express) of P2Y6 in monocytes
14) Confidence 0.24 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.26 Pain Relevance 0.24
In P2Y6 receptor expressing THP-1 cells, the extracellular signal-regulated kinase (ERK) antagonist PD98059 impairs UDP-induced IL-8 output whereas the p38 stress kinase antagonist SB203580 is without effect.
Gene_expression (expressing) of P2Y6 in THP-1 associated with stress and antagonist
15) Confidence 0.24 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.09 Pain Relevance 0.34
In contrast, UDP-challenged P2Y6 receptor 1321N cell transfectants produce IL-8 but not other cytokine products [45].
Gene_expression (transfectants) of P2Y6 associated with cytokine
16) Confidence 0.24 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.28 Pain Relevance 0.35
The inhibitory response to adenosine (P1 purinoceptor agonist), ATP (P2 purinoceptor agonist), RD, and SNS on the internal anal sphincter (IAS) was examined before and after 8-phenyltheophylline (P1 purinoceptor antagonist) and alpha,beta-methylene ATP (P2 purinoceptor antagonist that irreversibly binds and desensitizes P2 purinoceptor).
Gene_expression (desensitizes) of P2 purinoceptor in internal anal sphincter associated with adenocard, antagonist and agonist
17) Confidence 0.23 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 3421341 Disease Relevance 0 Pain Relevance 0.72
Human lymphocytes similarly express mRNAs encoding P2Y1, P2Y2, P2Y4, P2Y6 receptors and members of the P2X family, including P2X7, are detected in both B and T-lymphocyte populations [15, 17–21].
Gene_expression (express) of P2Y6 in lymphocytes
18) Confidence 0.11 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.20 Pain Relevance 0.20
P2Y14, a homologous Gi-coupled nucleotide receptor, is also expressed in DRG.
Gene_expression (expressed) of Gi-coupled nucleotide receptor in DRG
19) Confidence 0.01 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2865444 Disease Relevance 0.63 Pain Relevance 0.19

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