INT36891

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Context Info
Confidence 0.48
First Reported 1987
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 39
Total Number 39
Disease Relevance 34.32
Pain Relevance 9.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 7
brain 6
anterior 4
skeletal muscle tissue 3
skeletal muscle 2
Gd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 1851 99.98 Very High Very High Very High
bradykinin 1801 99.96 Very High Very High Very High
b2 receptor 1475 98.92 Very High Very High Very High
imagery 420 97.68 Very High Very High Very High
anesthesia 87 97.48 Very High Very High Very High
depression 11 95.80 Very High Very High Very High
fortral 6 94.32 High High
medulla 1 75.84 Quite High
Central nervous system 35 71.12 Quite High
Thalamus 76 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 2915 100.00 Very High Very High Very High
Brain Tumor 1402 99.68 Very High Very High Very High
Cancer 3725 99.40 Very High Very High Very High
Malignant Neoplastic Disease 544 98.00 Very High Very High Very High
Depression 11 95.80 Very High Very High Very High
Increased Venous Pressure Under Development 50 94.88 High High
Pressure Volume 2 Under Development 26 78.20 Quite High
Toxicity 13 66.80 Quite High
Solid Tumor 350 63.60 Quite High
Breast Cancer 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although there were relatively small increases in Gd-dendrimer particle sizes, there were significant decreases in particle extravasation across the BTB with increasing Gd-dendrimer generation, irrespective of RG-2 glioma host site.
Positive_regulation (increases) of Gd-dendrimer associated with glioma
1) Confidence 0.48 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 1.77 Pain Relevance 0
With each successively higher Gd-dendrimer generation there was an approximately 2 nm increase in Gd-dendrimer diameter.
Positive_regulation (increase) of Gd-dendrimer
2) Confidence 0.42 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 1.90 Pain Relevance 0
Gd-G6 dendrimers accumulated to lesser extent than Gd-G5 dendrimers in both orthotopic and ectopic tumor tissue extravascular spaces.
Positive_regulation (accumulated) of Gd-G6 associated with cancer
3) Confidence 0.34 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 1.42 Pain Relevance 0
However, these Gd-dendrimer generations extravasated to a greater extent across the BTB of ectopic RG-2 gliomas than the BTB of orthotopic RG-2 gliomas, as Gd-G5, Gd-G6, and Gd-G7 dendrimers achieved higher peak concentrations in the tumor tissue extravascular space of ectopic RG-2 malignant gliomas than in the tumor tissue extravascular space of orthotopic RG-2 malignant gliomas.
Positive_regulation (generations) of Gd-dendrimer associated with cancer and glioma
4) Confidence 0.30 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 1.25 Pain Relevance 0
Gd-G6 dendrimers also extravasated across the BTB of both orthotopic and ectopic RG-2 gliomas and accumulated within the respective tumor tissue extravascular spaces (Figure 2, panels B and F).
Positive_regulation (accumulated) of Gd-G6 associated with cancer and glioma
5) Confidence 0.30 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 1.39 Pain Relevance 0
With each successively higher Gd-dendrimer generation there was an approximately 2 nm increase in Gd-dendrimer diameter.
Positive_regulation (generation) of Gd-dendrimer
6) Confidence 0.30 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 1.87 Pain Relevance 0
Gd-G5 dendrimers readily extravasated across the BTB of both orthotopic and ectopic RG-2 gliomas and accumulated over time within the respective tumor tissue extravascular spaces, as evidenced by the significant positive contrast enhancement over time in the respective tumor tissues (Figure 3, first row).
Positive_regulation (accumulated) of Gd-G5 in row associated with cancer and glioma
7) Confidence 0.30 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 1.27 Pain Relevance 0.28
Gd-G7 dendrimers minimally extravasated across the BTB of both orthotopic and ectopic RG-2 gliomas and so minimally accumulated within the respective tumor tissue extravascular spaces (Figure 2, panels C and G).
Positive_regulation (accumulated) of Gd-G7 associated with cancer and glioma
8) Confidence 0.30 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 1.74 Pain Relevance 0
Gd-G5 dendrimers extravasated across the BTB of both orthotopic and ectopic RG-2 gliomas and accumulated within the respective tumor tissue extravascular spaces (Figure 2, panels A and E).
Positive_regulation (accumulated) of Gd-G5 associated with cancer and glioma
9) Confidence 0.30 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 0.80 Pain Relevance 0
Gd-G7 dendrimers accumulated to an even lesser extent than Gd-G6 dendrimers in both orthotopic and ectopic tumor tissue extravascular spaces.
Positive_regulation (accumulated) of Gd-G7 associated with cancer
10) Confidence 0.30 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 1.58 Pain Relevance 0
We found that the higher generation Gd-G5 through Gd-G8 dendrimers maintained steady state blood concentrations over the 120 minute long imaging session.
Positive_regulation (generation) of Gd-G5 in blood associated with imagery
11) Confidence 0.28 Published 2009 Journal J Transl Med Section Body Doc Link PMC2706803 Disease Relevance 0.86 Pain Relevance 0.12
There was substantial accumulation of rhodamine B Gd-G5 dendrimers within tumor tissue cells as shown by fluorescence microscopy ex vivo (low power, Figure 5D, left).
Positive_regulation (accumulation) of Gd-G5 associated with cancer
12) Confidence 0.17 Published 2008 Journal J Transl Med Section Body Doc Link PMC2639552 Disease Relevance 0.81 Pain Relevance 0.09
On analysis of the percent change in skeletal muscle tissue Gd-DTPA AUC, we found there to be significant increases in Gd-DTPA AUC with only Met-Lys-BK and labradimil infusions.
Positive_regulation (increases) of Gd-DTPA in skeletal muscle tissue associated with bradykinin
13) Confidence 0.14 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 0.85 Pain Relevance 0.43
In the Met-Lys-BK group to NS group comparison, there was a significant percent increase in Gd-DTPA AUC (p < 0.0001) (Figure 7C).
Positive_regulation (increase) of Gd-DTPA associated with bradykinin
14) Confidence 0.14 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 0.25 Pain Relevance 0.37
In the Met-Lys-BK group to NS group comparison, there was a significant percent increase in Gd-DTPA AUC for anterior brain (p = 0.0008) but not posterior brain (p = 0.0600) RG-2 gliomas (Figure 7A and 7B).
Positive_regulation (increase) of Gd-DTPA in anterior associated with bradykinin and glioma
15) Confidence 0.14 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 0.91 Pain Relevance 0.43
To quantify effect of increased Gd-DTPA half-life, for brain tumor and skeletal muscle tissues the percent change in Gd-DTPA AUC between the 1st and the 2nd Gd-DTPA concentration curve profiles.
Positive_regulation (increased) of Gd-DTPA in skeletal muscle tissues associated with brain tumor
16) Confidence 0.14 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 0.46 Pain Relevance 0.35
For anterior brain RG-2 gliomas, there was a statistically significant increase in the Gd-DTPA AUC with the intravenous infusions of Met-Lys-BK and labradimil.
Positive_regulation (increase) of Gd-DTPA in anterior associated with bradykinin and glioma
17) Confidence 0.14 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 1.21 Pain Relevance 0.33
In the case of anterior brain RG-2 gliomas, our findings suggest that observed increases in Gd-DTPA AUC due to the systemic infusion of bradykinin B2 agonists are dependent on RG-2 glioma tumor volume and therefore, the transvascular accumulation of Gd-DTPA increases with increasing tumor volume.
Positive_regulation (accumulation) of Gd-DTPA in anterior associated with cancer, agonist, bradykinin and glioma
18) Confidence 0.14 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 1.30 Pain Relevance 0.40
In the case of anterior brain RG-2 gliomas, our findings suggest that observed increases in Gd-DTPA AUC due to the systemic infusion of bradykinin B2 agonists are dependent on RG-2 glioma tumor volume and therefore, the transvascular accumulation of Gd-DTPA increases with increasing tumor volume.
Positive_regulation (increases) of Gd-DTPA in anterior associated with cancer, agonist, bradykinin and glioma
19) Confidence 0.14 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 1.32 Pain Relevance 0.39
Being metabolically stable bradykinin B2 receptor agonists, Met-Lys-BK and labradimil increased the blood half-life of Gd-DTPA for sufficiently long to significantly increase the transvascular accumulation of Gd-DTPA into the extravascular brain tumor space.
Positive_regulation (accumulation) of Gd-DTPA in brain associated with agonist, b2 receptor, bradykinin and brain tumor
20) Confidence 0.14 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 1.21 Pain Relevance 0.37

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