INT36892

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Context Info
Confidence 0.68
First Reported 1987
Last Reported 2011
Negated 4
Speculated 0
Reported most in Body
Documents 57
Total Number 57
Disease Relevance 12.15
Pain Relevance 3.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 22
effector T lymphocytes 2
lymph nodes 1
macrophage 1
DP thymocyte 1
Trav6-3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 834 99.92 Very High Very High Very High
Kinase C 23 99.84 Very High Very High Very High
agonist 23 99.56 Very High Very High Very High
rheumatoid arthritis 203 97.88 Very High Very High Very High
chemokine 95 97.88 Very High Very High Very High
Inflammation 500 95.84 Very High Very High Very High
fortral 6 93.92 High High
Inflammatory response 42 91.80 High High
tolerance 43 89.64 High High
antagonist 21 89.56 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 88 99.96 Very High Very High Very High
Alagille Syndrome 2 99.32 Very High Very High Very High
T-cell Lymphoma 11 99.28 Very High Very High Very High
Cancer 435 98.76 Very High Very High Very High
Necrosis 37 98.52 Very High Very High Very High
Acute Disease 11 98.20 Very High Very High Very High
Rheumatoid Arthritis 211 97.88 Very High Very High Very High
Cold Sores 40 96.52 Very High Very High Very High
Infection 227 96.16 Very High Very High Very High
INFLAMMATION 549 95.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies have found that a 95% reduction in TCR expression does not adversely affect response to foreign Ags, indicating that T cells have an excess of TCR for Ag recognition.
Positive_regulation (excess) of TCR in T cells associated with alagille syndrome
1) Confidence 0.68 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18490725 Disease Relevance 0.18 Pain Relevance 0
Because self-reactive T cells may have low affinity for peptide:MHC, we investigated whether myelin-reactive T cells require these excess TCR for optimal response.
Positive_regulation (excess) of TCR in T cells
2) Confidence 0.45 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18490725 Disease Relevance 0.18 Pain Relevance 0
However PTPMEG deletion in vivo does not induce TCR?
Neg (not) Positive_regulation (induce) of TCR
3) Confidence 0.23 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873500 Disease Relevance 0.32 Pain Relevance 0.10
Moreover, clearance of Staphylococcus Enterotoxin B (SEB)-activated TCR V?
Positive_regulation (activated) of TCR
4) Confidence 0.20 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.83 Pain Relevance 0.03
Without antigen, however, phase two is abbreviated and T cell–DC contacts do not result in the expression of activation markers (CD25), cytokine production (IL-2) or cell division but do induce TCR signaling, which might represent TCR interaction with self-MHC ligands required for optimal foreign antigen reactivity [42].
Neg (not) Positive_regulation (induce) of TCR in T cell associated with cytokine
5) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297591 Disease Relevance 0 Pain Relevance 0.09
Results reported herein clearly show that cells from AKR/J T cell lymphomas are susceptible to be deleted as a consequence of Sag signaling via TCR.
Positive_regulation (consequence) of TCR in T cell associated with t-cell lymphoma
6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.92 Pain Relevance 0
Recently, we described that the Vav1 and RasGRF2 GEFs play synergistic roles in the activation of specific T–cell receptor (TCR) downstream signaling pathways, including the optimal activation of phospholipase C–?
Positive_regulation (activation) of TCR in T-cell
7) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.39 Pain Relevance 0.04
This was associated with accumulation of the TCR?
Positive_regulation (accumulation) of TCR
8) Confidence 0.18 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.39 Pain Relevance 0.25
rearrangement, and test the newly generated TCR?
Positive_regulation (generated) of TCR
9) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.06 Pain Relevance 0
By analogy to conventional T cells, which stop migrating in response to antigen in vitro [24], we hypothesized that TCR activation would modify the patrolling behavior of hepatic NKT cells.
Positive_regulation (activation) of TCR in T cells
10) Confidence 0.16 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0 Pain Relevance 0
However, when data were stratified according to validated EULAR clinical response criteria we found that at 30 weeks the best clinical outcomes were associated with an accumulation in the percent CD3+TCR?
Positive_regulation (accumulation) of TCR
11) Confidence 0.16 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.33 Pain Relevance 0.11
Failure to be selected results in additional TCR?
Positive_regulation (results) of TCR
12) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.09 Pain Relevance 0
These results demonstrate that Fas activation, which requires repeated TCR stimulation to upregulate FasL in T cells, is not involved in the shutdown of acute immune responses; instead, this death is mediated predominantly by Bim.


Positive_regulation (stimulation) of TCR in T cells associated with death
13) Confidence 0.14 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 1.37 Pain Relevance 0
Indeed, it may be that the evolution of a role for Gads in mediating the interaction between LAT and SLP-76 has occurred because of its role in facilitating weak signaling by the pre-TCR to ensure an optimal number of mature T cells in the circulation rather than to facilitate TCR or platelet activation at higher agonist concentrations.
Positive_regulation (activation) of TCR in mature T cells associated with agonist
14) Confidence 0.13 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0.12 Pain Relevance 0.05
Gads binds constitutively to SLP-76 and associates with LAT upon T-cell receptor (TCR) activation forming a LAT signalosome that is critical for activation of PLC?
Positive_regulation (activation) of TCR in T-cell
15) Confidence 0.13 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
At the DP thymocyte stage, cells undergo TCR?
Positive_regulation (undergo) of TCR in DP thymocyte
16) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.06 Pain Relevance 0
If circulating TCR?
Positive_regulation (circulating) of TCR
17) Confidence 0.13 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.43 Pain Relevance 0.26
The results described thus far indicated that circulating TCR?
Positive_regulation (circulating) of TCR
18) Confidence 0.13 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.07 Pain Relevance 0.25
To define alternative signaling pathways of effector function, we prepared bulk populations of TCR?
Positive_regulation (populations) of TCR
19) Confidence 0.13 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.10 Pain Relevance 0.25
Taken together, these results suggest that antigen-experienced TCR?
Positive_regulation (experienced) of TCR
20) Confidence 0.13 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.22 Pain Relevance 0.26

General Comments

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