INT36921

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Context Info
Confidence 0.26
First Reported 1983
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 6.49
Pain Relevance 5.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mdk) extracellular region (Mdk)
Anatomy Link Frequency
neuronal 1
neurons 1
pancreas 1
adult brain 1
myotubes 1
Mdk (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 35 100.00 Very High Very High Very High
substance P 7 100.00 Very High Very High Very High
Opioid 8 99.48 Very High Very High Very High
Morphine 10 99.24 Very High Very High Very High
opiate 8 99.00 Very High Very High Very High
antagonist 8 98.24 Very High Very High Very High
addiction 17 98.16 Very High Very High Very High
Nicotine 5 97.84 Very High Very High Very High
narcan 14 97.80 Very High Very High Very High
Somatostatin 10 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Toxicity 5 99.92 Very High Very High Very High
Skin Cancer 140 99.80 Very High Very High Very High
Hepatocellular Cancer 79 99.12 Very High Very High Very High
Disease 48 96.44 Very High Very High Very High
Aids-related Complex 12 96.40 Very High Very High Very High
Philadelphia Chromosome 1 96.04 Very High Very High Very High
Cancer 250 95.76 Very High Very High Very High
INFLAMMATION 60 95.64 Very High Very High Very High
Autoimmune Disease 13 94.96 High High
Liver Cancer 24 94.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MEK inhibition is a prime target for melanoma therapy given BRAF's downstream dependence on MEK for signal propagation [Figure 1].
Regulation (target) of MEK associated with addiction and skin cancer
1) Confidence 0.26 Published 2010 Journal Journal of Carcinogenesis Section Body Doc Link PMC2862505 Disease Relevance 0.63 Pain Relevance 0.05
To demonstrate a possible circadian rhythm in feeding-induced changes in Met-enkephalin (MEK), 54 male rats initially weighing 255 +/- 3 g were adapted to a 12-hr fast during the light (light-fasted) or dark (dark-fasted) phase of the circadian cycle, then sacrificed before (non-fed) or after (fed) being allowed to eat a meal.
Regulation (changes) of MEK associated with enkephalin
2) Confidence 0.24 Published 1987 Journal Physiol. Behav. Section Abstract Doc Link 3432401 Disease Relevance 0 Pain Relevance 0.62
The effects of MEK (100 nM) were modulated by the prevailing glucose concentration.
Regulation (modulated) of MEK associated with enkephalin
3) Confidence 0.19 Published 1983 Journal Endocrinology Section Abstract Doc Link 6135603 Disease Relevance 0 Pain Relevance 1.54
Finally, ubiquitin hyperexpression induced by glucocorticoids in L6 myotubes was shown to depend on the activity of both MEK, the kinase upstream of ERK, and the Sp1 transcription factor [28].


Regulation (depend) of MEK in myotubes
4) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.66 Pain Relevance 0.08
Although the etiology and pathogenesis of HCC remain unclear, our observation suggests a role for the MEK-MAPK regulatory network.
Regulation (role) of MEK associated with hepatocellular cancer
5) Confidence 0.15 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.00 Pain Relevance 0
Although the etiology and pathogenesis of HCC remain unclear, our observation suggests a role for the MEK-MAPK regulatory network.
Regulation (regulatory) of MEK associated with hepatocellular cancer
6) Confidence 0.15 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.00 Pain Relevance 0
The indirect effect of PTPH1 could be mediated by the dephosphorylation of one or several signaling components upstream of Mek and Jnk, such as the TCR-associated protein tyrosine kinases (PTK) or their immediate targets.
Regulation (targets) of Mek
7) Confidence 0.14 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873500 Disease Relevance 0.19 Pain Relevance 0.03
To assess the nature and extent of the influence that opiates exert on the endocrine pancreas, we examined the effects of MET-enkephalin (MEK), leu-enkephalin, morphine, and the opiate antagonist naloxone (NAL) as well as adrenergic and cholinergic blockade on the hormone release from the isolated perfused dog pancreas.
Spec (examined) Regulation (effects) of MEK in pancreas associated with antagonist, narcan, enkephalin, opiate and morphine
8) Confidence 0.14 Published 1983 Journal Endocrinology Section Abstract Doc Link 6135603 Disease Relevance 0 Pain Relevance 1.35
There are also neuronal pathways for direct reciprocal regulations of SP and MEK. 4.
Regulation (regulations) of MEK in neuronal associated with enkephalin and substance p
9) Confidence 0.10 Published 1995 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 7545560 Disease Relevance 0.09 Pain Relevance 0.93
These data indicate that MEK/ERK activation is also an important mediator of striatal gene regulation in the adult brain.


Regulation (regulation) of MEK in adult brain
10) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669182 Disease Relevance 0.10 Pain Relevance 0
To assess whether the phosphorylation and activation of such factors in striatal neurons is dependent on MEK and ERK, we tested whether these effects were sensitive to pharmacologic inhibition of the MAPK cascade.
Spec (whether) Regulation (dependent) of MEK in neurons
11) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669182 Disease Relevance 0.07 Pain Relevance 0
The BCR-ABL kinase is constitutively active and via downstream signaling regulates multiple survival pathways, including Ras/Raf/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK), PI3/AKT, NF-?
Regulation (regulates) of MEK
12) Confidence 0.02 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.98 Pain Relevance 0
ERK1/2 are stimulated by mitogen-activated protein kinase kinases (MEK1/2), but little is known about the regulation of MEK activity by opioid drugs.
Regulation (regulation) of MEK associated with opioid
13) Confidence 0.02 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16678156 Disease Relevance 0.25 Pain Relevance 0.98
In contrast, none of the extracts had any significant effect on MEK whereas only a cake saponin subfraction enhanced insulin-induced PKB/Akt activation.
Regulation (effect) of MEK
14) Confidence 0.01 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Abstract Doc Link PMC1513146 Disease Relevance 0.14 Pain Relevance 0
More specifically, the flavonoid naringenin impaired the PI3K and MAPK pathways; it inhibits the phosphorylation of ERK1/2 without affecting the upstream kinase, MEK (27).
Neg (without) Regulation (affecting) of MEK
15) Confidence 0.01 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1513146 Disease Relevance 0.40 Pain Relevance 0
A number of drugs targeting the kinases p38, JNK, MEK, IKK2, JAK3, Lck, and Syk are currently undergoing clinical trials for the treatment of diseases related to inflammation and autoimmunity.
Regulation (drugs tar) of MEK associated with autoimmune disease, inflammation and disease
16) Confidence 0.01 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.97 Pain Relevance 0.22

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