INT36927

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Context Info
Confidence 0.26
First Reported 1987
Last Reported 2000
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 0.33
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
STR 4
spinal 2
caudate-putamen 2
Tac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dopamine receptor 4 100.00 Very High Very High Very High
opiate 4 99.82 Very High Very High Very High
Dopamine 16 99.68 Very High Very High Very High
Inflammatory stimuli 1 96.00 Very High Very High Very High
Intracerebroventricular 2 93.44 High High
Serotonin 4 92.92 High High
Enkephalin 8 90.16 High High
Endogenous opioid 1 89.68 High High
Neurotransmitter 2 85.68 High High
Morphine 4 80.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 1 96.00 Very High Very High Very High
Nociception 5 90.32 High High
Pain 2 35.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was designed to determine if increased 5-HT release from sprouted terminals influences dysregulated preprotachykinin (PPT) and preproenkephalin (PPE) mRNA expression in the DA-depleted STR.
Regulation (influences) of Transcription (expression) of PPT in STR associated with dopamine
1) Confidence 0.26 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11000480 Disease Relevance 0 Pain Relevance 0.62
The present study was designed to determine if increased 5-HT release from sprouted terminals influences dysregulated preprotachykinin (PPT) and preproenkephalin (PPE) mRNA expression in the DA-depleted STR.
Regulation (dysregulated) of Transcription (expression) of PPT in STR associated with dopamine
2) Confidence 0.26 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11000480 Disease Relevance 0 Pain Relevance 0.62
We have investigated the effect of dopamine receptor blockade on striatal proenkephalin mRNA and protachykinin mRNA by Northern gel analysis and by in situ hybridization histochemistry.
Spec (investigated) Regulation (effect) of Transcription (mRNA) of protachykinin associated with dopamine receptor
3) Confidence 0.24 Published 1987 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 3434462 Disease Relevance 0 Pain Relevance 0.16
The changes in mRNA levels for protachykinin and proenkephalin were uniform throughout the caudate-putamen of the rat as determined by in situ hybridization histochemistry.
Regulation (changes) of Transcription (levels) of protachykinin in caudate-putamen
4) Confidence 0.24 Published 1987 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 3434462 Disease Relevance 0 Pain Relevance 0.16
The results of this study indicate that pretreatment with opiate ligands modulates the expression of tachykinin peptide and neurokinin receptor encoding mRNAs in spinal systems following a peripheral chemogenic inflammatory stimulus.
Regulation (modulates) of Transcription (expression) of tachykinin in spinal associated with opiate and inflammatory stimuli
5) Confidence 0.13 Published 1995 Journal Neuroscience Section Abstract Doc Link 7536308 Disease Relevance 0.33 Pain Relevance 0.71

General Comments

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