INT36943

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Context Info
Confidence 0.37
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 4.09
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CHKB)
Anatomy Link Frequency
upper 2
neutrophils 2
muscle 1
heart 1
mesenchymal cells 1
CHKB (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 4 100.00 Very High Very High Very High
Angina 16 99.76 Very High Very High Very High
Inflammation 5 99.72 Very High Very High Very High
Kinase C 47 99.10 Very High Very High Very High
cva 26 98.76 Very High Very High Very High
Enkephalin 14 94.84 High High
cINOD 3 92.00 High High
Central nervous system 3 85.88 High High
opiate 4 82.32 Quite High
ischemia 57 72.56 Quite High
Disease Link Frequency Relevance Heat
Carcinoma 5 100.00 Very High Very High Very High
Depression 4 100.00 Very High Very High Very High
INFLAMMATION 8 99.72 Very High Very High Very High
Melanoma 39 99.70 Very High Very High Very High
Angina 16 98.98 Very High Very High Very High
Cv General 3 Under Development 22 98.76 Very High Very High Very High
Myalgia 20 98.44 Very High Very High Very High
Cancer 36 96.48 Very High Very High Very High
Metastasis 36 95.66 Very High Very High Very High
Injury 43 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PURPOSE: Unaccustomed exercise is associated with an elevated plasma creatine kinase (CK), myofibrillar inflammation, and delayed onset muscle soreness (DOMS).
CK Binding (associated) of in muscle associated with inflammation and myalgia
1) Confidence 0.37 Published 1999 Journal Med Sci Sports Exerc Section Abstract Doc Link 9927002 Disease Relevance 0.30 Pain Relevance 0.19
The markers normally used include creatine kinase (CK), heart-fatty acid binding protein, myoglobin, TnI and ?
CK Binding (binding) of in heart
2) Confidence 0.36 Published 2008 Journal British Journal of Sports Medicine Section Body Doc Link PMC2564766 Disease Relevance 0.25 Pain Relevance 0.07
20 min duration) angina chest pain at rest or on minimal exercise within 12 h before randomization, with one of the following electrocardiographic or laboratory findings: ST-segment depression >1 mm in at least two contiguous leads; T-wave inversion >1.5 mm in at least three contiguous leads; transient ST-segment elevation >1 mm with duration of <30 min in at least two contiguous leads; total CK and/or CK-MB >1.5 times upper limit of the normal range; and troponin I >2.0 ?
CK Binding (randomization) of in upper associated with angina, depression and cva
3) Confidence 0.31 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 0.61 Pain Relevance 0.31
20 min duration) angina chest pain at rest or on minimal exercise within 12 h before randomization, with one of the following electrocardiographic or laboratory findings: ST-segment depression >1 mm in at least two contiguous leads; T-wave inversion >1.5 mm in at least three contiguous leads; transient ST-segment elevation >1 mm with duration of <30 min in at least two contiguous leads; total CK and/or CK-MB >1.5 times upper limit of the normal range; and troponin I >2.0 ?
CK-MB Binding (randomization) of in upper associated with angina, depression and cva
4) Confidence 0.27 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 0.61 Pain Relevance 0.31
The interpretation of discordant CK and troponin levels is discussed.
CK Binding (interpretation) of
5) Confidence 0.24 Published 2010 Journal CJEM Section Abstract Doc Link 20078923 Disease Relevance 0.31 Pain Relevance 0.18
CK participated in the design of the study, obtained funding, enrolled patients, and participated in drafting the manuscript

Pre-publication history

CK Binding (participated) of
6) Confidence 0.18 Published 2008 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2245927 Disease Relevance 0.07 Pain Relevance 0
CK participated in the design of the study, obtained funding, enrolled patients, and participated in drafting the manuscript

Pre-publication history

CK Binding (funding) of
7) Confidence 0.18 Published 2008 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC2245927 Disease Relevance 0.07 Pain Relevance 0
This observation coupled with the previous report that 25OH-C possesses the ability to amplify the Receptor Ck dependent generation of PA [42] suggests that PA generation followed by the conversion of PA to DAG and PKC activation may be the point at which 25OH-C interacts with Receptor Ck dependent signaling pathway.
Ck Binding (interacts) of associated with kinase c
8) Confidence 0.17 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0.25
These CK+ mesenchymal cells are associated with TA flaps and give rise to SE cells directly covering the ovarian stroma (yellow arched arrow, step 1).
CK Binding (associated) of in mesenchymal cells
9) Confidence 0.15 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC420494 Disease Relevance 0.05 Pain Relevance 0
During association of oocytes (panel D) with CK+ nests (see serial section in panel E) in the lower ovarian cortex, abundant MAPK immunoexpression was apparent in the oocyte nucleus and cytoplasm.
CK Binding (association) of in cortex
10) Confidence 0.15 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC420494 Disease Relevance 0.08 Pain Relevance 0
Thus, a broader panel of immuno-markers may be useful in distinguishing between metastases of malignant melanoma and other metastatic malignancies when the lesion is morphologically undifferentiated; Gupta et al. [15], in fact, reported four cases of morphologically undifferentiated melanoma that showed a positivity for HMB45 (two cases), S100 (one case), vimentin (three cases), NKI/C3 (two cases), NKI/Bteb (one case) and CK (three cases).
CK Binding (positivity) of associated with melanoma, carcinoma and metastasis
11) Confidence 0.12 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2396655 Disease Relevance 1.40 Pain Relevance 0
Initial attempts to detect interaction of leuEK and metEK with neutrophils yielded inconsistent results.
leuEK Binding (interaction) of in neutrophils
12) Confidence 0.08 Published 1987 Journal J Burn Care Rehabil Section Abstract Doc Link 3436973 Disease Relevance 0.09 Pain Relevance 0.73
Initial attempts to detect interaction of leuEK and metEK with neutrophils yielded inconsistent results.
metEK Binding (interaction) of in neutrophils
13) Confidence 0.05 Published 1987 Journal J Burn Care Rehabil Section Abstract Doc Link 3436973 Disease Relevance 0.09 Pain Relevance 0.73
Related to this, it should be noted that the large degree of variability in subjects' responses in both CK activity and CRP also interfered with our ability to detect group differences.
CK Binding (interfered) of
14) Confidence 0.02 Published 2007 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2131751 Disease Relevance 0.16 Pain Relevance 0

General Comments

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