INT36947

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Context Info
Confidence 0.45
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 11.04
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PNLIP) small molecule metabolic process (PNLIP) extracellular region (PNLIP)
lipid metabolic process (PNLIP)
Anatomy Link Frequency
plasma 1
acinar cells 1
bile 1
PNLIP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 41 99.38 Very High Very High Very High
Bile 2 96.80 Very High Very High Very High
Chronic pancreatitis 20 95.92 Very High Very High Very High
Pain 23 84.92 Quite High
cva 4 83.52 Quite High
Bioavailability 1 76.00 Quite High
metalloproteinase 3 70.96 Quite High
abdominal pain 2 58.76 Quite High
Inflammatory response 15 50.80 Quite High
cytokine 6 43.68 Quite Low
Disease Link Frequency Relevance Heat
Pre-term Labor 150 100.00 Very High Very High Very High
Cancer 129 99.76 Very High Very High Very High
Chorioamnionitis 51 99.52 Very High Very High Very High
INFLAMMATION 56 99.38 Very High Very High Very High
Premature Birth 171 98.44 Very High Very High Very High
Pancreatic Cancer 130 98.24 Very High Very High Very High
Frailty 1 96.76 Very High Very High Very High
Birth Weight 9 96.48 Very High Very High Very High
Pancreatitis 30 95.92 Very High Very High Very High
Malignant Neoplastic Disease 4 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M PTL group.
Gene_expression (group) of PTL
1) Confidence 0.45 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.37 Pain Relevance 0
The inhibition rate (IR) was calculated as follows: IR = (1-A value of PTL well/A value of control well) × 100%

Flow Cytometry

Gene_expression (value) of PTL
2) Confidence 0.45 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0 Pain Relevance 0
M PTL groups were (94 ± 7)/HPF and (58 ± 8)/HPF respectively, which were less than (146 ± 10)/HPF of control group (P < 0.05) (Fig. 4).


Gene_expression (groups) of PTL
3) Confidence 0.45 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.84 Pain Relevance 0
Genes encoding digestive enzymes produced by acinar cells such as amylase (AMY2A), elastase (ELA3A, ELA3B), carboxypeptidase A (CPA2), pancreatic lipase (PNLIP), and trypsin (PRSS2) were enriched in this cluster (Figures 1, “Acinar” cluster).
Gene_expression (produced) of pancreatic lipase in acinar cells
4) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.15 Pain Relevance 0.07
The tumor cells were negative for C-erbB2, MUC1, trypsin, pancreatic amylase and pancreatic lipase.
Neg (negative) Gene_expression (negative) of pancreatic lipase associated with cancer
5) Confidence 0.31 Published 2009 Journal Pathol. Int. Section Abstract Doc Link 19121093 Disease Relevance 1.02 Pain Relevance 0.06
Antenatal glucocorticoids and PTL
Gene_expression (glucocorticoids) of PTL
6) Confidence 0.15 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2861440 Disease Relevance 1.10 Pain Relevance 0.04
A meta-analysis over a decade ago102 showed that progesterone was beneficial in reducing PTL: odds ratio 0.43 (95% CI 0.20, 0.89); PTB: odds ratio 0.50 (95% CI 0.30, 0.85) and low birth weight (<2500 g): odds ratio 0.50 (95% CI 0.27, 0.80).
Gene_expression (reducing) of PTL associated with birth weight, premature birth and pre-term labor
7) Confidence 0.12 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697509 Disease Relevance 0.67 Pain Relevance 0.12
However there were a number of cases in the PPROM and PTL groups that were positive for either bacteria or histological chorioamnionitis but not for both.
Gene_expression (groups) of PTL associated with chorioamnionitis and pre-term labor
8) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785424 Disease Relevance 1.46 Pain Relevance 0.11
In indicated preterm delivery there was a complete absence of histological chorioamnionitis, in contrast PPROM and PTL groups had significantly higher incidence of histological chorioamnionitis (88% and 68% respectively).
Gene_expression (groups) of PTL associated with chorioamnionitis, premature birth and pre-term labor
9) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785424 Disease Relevance 1.55 Pain Relevance 0.13
However, although the data in Figure 4 shows that a similar proportion of the PTL with intact membranes and PPROM groups had both bacteria and chorioamnionitis 25% of cases in the PPROM group had chorioamnionitis but no bacteria, whilst approx 25% of the PTL group had bacteria but no chorioamnionitis.
Gene_expression (proportion) of PTL associated with chorioamnionitis and pre-term labor
10) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785424 Disease Relevance 0.93 Pain Relevance 0.03
Project name: Pancreatic Expression database
Gene_expression (database) of Pancreatic Expression
11) Confidence 0.06 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2216037 Disease Relevance 0.46 Pain Relevance 0
Using the Pancreatic Expression database, it is possible to search and retrieve genes/proteins expressed only in pancreatic cancer and not in chronic pancreatitis and then ask which of these are present in urine and/or plasma.
Gene_expression (database) of Pancreatic Expression in plasma associated with pancreatic cancer and chronic pancreatitis
12) Confidence 0.06 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2216037 Disease Relevance 0.46 Pain Relevance 0.10
In human milk however, palmitic acid esterified at the sn-2 position of the triacylglycerol molecule is well absorbed as 2-monopalmitin, since it readily forms mixed micelles with bile acids [11,13-15].
Gene_expression (position) of triacylglycerol molecule in bile associated with bile
13) Confidence 0.04 Published 2007 Journal Nutr J Section Body Doc Link PMC1852321 Disease Relevance 0.06 Pain Relevance 0.05
One implant type was made of PL-DL-lactide (PLA), the second one was a titanium core partially covered with PLA.
Gene_expression (covered) of PL-DL-lactide
14) Confidence 0.04 Published 2009 Journal The Open Orthopaedics Journal Section Abstract Doc Link PMC2703834 Disease Relevance 0.24 Pain Relevance 0.08
Simultaneously, the inflammatory process (represented by serum levels of trypsin, lipase, and pancreatic isoamylase) was terminated in all 23 patients.
Gene_expression (levels) of pancreatic isoamylase associated with inflammation
15) Confidence 0.01 Published 1987 Journal Pancreas Section Abstract Doc Link 3438310 Disease Relevance 0.72 Pain Relevance 0.45

General Comments

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