INT36962

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Context Info
Confidence 0.28
First Reported 1987
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 5.57
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 1
sympathetic 1
parasympathetic 1
vs (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 14 98.08 Very High Very High Very High
withdrawal 2 94.28 High High
analgesia 6 94.16 High High
cytokine 70 93.68 High High
addiction 47 93.56 High High
antagonist 16 92.64 High High
Hippocampus 42 85.36 High High
Analgesic 2 84.56 Quite High
tail-flick 2 83.12 Quite High
bDMF 10 69.64 Quite High
Disease Link Frequency Relevance Heat
Obesity 42 100.00 Very High Very High Very High
Heart Rate Under Development 16 100.00 Very High Very High Very High
Pressure And Volume Under Development 14 100.00 Very High Very High Very High
Disease 50 99.48 Very High Very High Very High
INFLAMMATION 58 98.08 Very High Very High Very High
Epilepsy 22 95.64 Very High Very High Very High
Body Weight 48 95.52 Very High Very High Very High
Convulsion 30 95.08 Very High Very High Very High
Hyperglycemia 6 94.12 High High
Hypoxia 10 93.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the increase in HR in response to VS appears to be partly due to a decrease in parasympathetic activity.
Positive_regulation (increase) of VS in parasympathetic associated with heart rate under development
1) Confidence 0.28 Published 1987 Journal Physiol. Behav. Section Abstract Doc Link 3441531 Disease Relevance 0.94 Pain Relevance 0.46
Administration of chlorisondamine (5 mg/kg, IV), which eliminates both sympathetic and parasympathetic influences, abolished the increase in BP and HR in response to VS, indicating that VS stimulates autonomic activity involved in the control of these two processes and that the tachycardia resulted from vagal withdrawal as well as sympathetic activation.
Positive_regulation (increase) of VS in sympathetic associated with heart rate under development, pressure and volume under development and withdrawal
2) Confidence 0.28 Published 1987 Journal Physiol. Behav. Section Abstract Doc Link 3441531 Disease Relevance 1.02 Pain Relevance 0.35
Preliminary experiments were performed comparing diet-induced obese (DIO) vs lean mice prior to conducting experiments on HFD-fed GhrR KO vs WT mice (Figure 1).


Positive_regulation (induced) of vs associated with obesity
3) Confidence 0.22 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.43 Pain Relevance 0
Significant increases in the GIR of LFD-fed GhrR KO mice (41.0 ± 1.4 mg/kg/min) vs WT littermates (33.1 ± 2.1 mg/kg/min) as well as HFD-fed GhrR KO mice (29.1 ± 2.1 mg/kg/min) vs WT (22.0 ± 2.3 mg/kg/min) were observed (Figure 3A).
Positive_regulation (increases) of vs
4) Confidence 0.21 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.53 Pain Relevance 0.03
Significant increases in the GIR of LFD-fed GhrR KO mice (41.0 ± 1.4 mg/kg/min) vs WT littermates (33.1 ± 2.1 mg/kg/min) as well as HFD-fed GhrR KO mice (29.1 ± 2.1 mg/kg/min) vs WT (22.0 ± 2.3 mg/kg/min) were observed (Figure 3A).
Positive_regulation (increases) of vs
5) Confidence 0.21 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.53 Pain Relevance 0.03
We report pooled “nontemplate” genome-wide association studies of two independent samples of substance dependent vs control research volunteers (n?
Positive_regulation (dependent) of vs
6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2809089 Disease Relevance 0.09 Pain Relevance 0.12
Levels of HMGB-1 at 2, 6, and 12 hours post LPS were no different from baseline levels; a 1.5-fold increase was observed from 24 hours after LPS and remained elevated up to day 3 (Figure 1d; 25.77 ± 4.2 pg/ml, P < 0.01, P < 0.001 vs control).
Positive_regulation (elevated) of vs
7) Confidence 0.19 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 0.30 Pain Relevance 0.36
Levels of HMGB-1 at 2, 6, and 12 hours post LPS were no different from baseline levels; a 1.5-fold increase was observed from 24 hours after LPS and remained elevated up to day 3 (Figure 1d; 25.77 ± 4.2 pg/ml, P < 0.01, P < 0.001 vs control).
Positive_regulation (increase) of vs
8) Confidence 0.19 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 0.30 Pain Relevance 0.37
This pilot study assessed the effects of enhanced proprioceptive feedback using step-synchronized vibration stimulation of the soles (S-VS) on gait in PD.
Positive_regulation (stimulation) of S-VS associated with disease
9) Confidence 0.06 Published 2006 Journal J Neuroengineering Rehabil Section Abstract Doc Link PMC1471796 Disease Relevance 0.55 Pain Relevance 0
Given the divergent patterns of regulation of KCC2 in neurons with depolarizing vs hyperpolarizing GABAAergic signaling (Fig. 2), can these observations be extended to neonatal and pediatric epilepsies, when the brain is still immature?
Positive_regulation (depolarizing) of vs in neurons associated with epilepsy
10) Confidence 0.04 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.73 Pain Relevance 0.21
Desflurane increased the FoC60 as compared to Control group (FoC60: 84 ± 6% of baseline vs.
Positive_regulation (increased) of vs
11) Confidence 0.03 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.17 Pain Relevance 0

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