INT36979

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Context Info
Confidence 0.39
First Reported 1987
Last Reported 2007
Negated 1
Speculated 2
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.50
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
chemoreceptor cells 2
tubule 2
Pah (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 2 89.36 High High
halothane 1 73.28 Quite High
Neurotransmitter 2 39.72 Quite Low
Catecholamine 1 35.36 Quite Low
Dopamine 3 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
potassium channel 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 60 89.48 High High
Diuresis 1 75.00 Quite High
Cv General 4 Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High doses of furosemide (120 mg/kg as intravenous bolus) reversibly decreased the CPAH/CTEA ratio, suggesting that furosemide may compete for PAH secretion in the proximal tubule.
Spec (may) Negative_regulation (compete) of Localization (secretion) of PAH in tubule
1) Confidence 0.39 Published 1987 Journal Ren Physiol Section Abstract Doc Link 3447247 Disease Relevance 0.07 Pain Relevance 0.09
Hence, the aims of the present study were to determine the effects of blockade of purinoceptors with suramin, or suppression of PAH activity with iron chelator CPX, and with the oxoglutarate analogue dimethyloxalylglycine (DMOG), on the endogenous NO release produced in some intraglomic structure, probably chemoreceptor cells and efferent fibers.


Spec (probably) Negative_regulation (suppression) of Neg (NO) Localization (release) of PAH in chemoreceptor cells
2) Confidence 0.37 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.43 Pain Relevance 0.11

General Comments

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