INT3699

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Context Info
Confidence 0.74
First Reported 1977
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 24
Total Number 25
Disease Relevance 12.06
Pain Relevance 11.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (H2-Ab1) plasma membrane (H2-Ab1) intracellular (H2-Ab1)
transcription factor binding (H2-Ab1)
Anatomy Link Frequency
ileum 2
monocyte 2
aortas 1
Th1 cells 1
tail 1
H2-Ab1 (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 13 100.00 Very High Very High Very High
Adelta 7 100.00 Very High Very High Very High
nociceptor 6 100.00 Very High Very High Very High
Catecholamine 3 99.78 Very High Very High Very High
antagonist 29 99.72 Very High Very High Very High
Periaqueductal grey 5 99.68 Very High Very High Very High
Opioid 5 99.56 Very High Very High Very High
c fibre 10 99.40 Very High Very High Very High
tolerance 11 99.36 Very High Very High Very High
tail-flick 6 98.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 4 99.86 Very High Very High Very High
Urological Neuroanatomy 5 99.68 Very High Very High Very High
Cancer 52 98.84 Very High Very High Very High
Disease 168 98.64 Very High Very High Very High
Dysmenorrhea 9 98.60 Very High Very High Very High
Adhesions 36 98.36 Very High Very High Very High
Ganglion Cysts 9 97.76 Very High Very High Very High
Stress 141 96.52 Very High Very High Very High
Hypergammaglobulinemia 1 95.32 Very High Very High Very High
INFLAMMATION 126 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, expression of marker proteins for glia activation like major histocompatibility class II and galectin-3 was found to be affected.
Gene_expression (expression) of major histocompatibility class II
1) Confidence 0.74 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16890918 Disease Relevance 0.75 Pain Relevance 0.16
Pretreatment with 2 mg/kg of naloxone antagonized both the tail-flick activity and blocked the increases in catecholamine synthesis produced by beta-HHC.
Gene_expression (produced) of beta-HHC in tail associated with catecholamine, tail-flick and narcan
2) Confidence 0.66 Published 1977 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 839438 Disease Relevance 0 Pain Relevance 1.08
Interleukin-6 (IL-6) is a B-cell growth factor and its altered expression has been linked to several human diseases and malignancies, including MCD with its characteristic plasmacytosis and hypergammaglobulinemia.
Gene_expression (expression) of a B-cell growth factor in B-cell associated with hypergammaglobulinemia and disease
3) Confidence 0.58 Published 2005 Journal Virol J Section Body Doc Link PMC1243244 Disease Relevance 0.57 Pain Relevance 0.12
Ondansetron produced little effect on the electrically evoked responses (Abeta-, Adelta- and C-fibre-evoked responses, postdischarge); however, responses to mechanical punctate stimuli (von Frey filaments 1-75 g) were markedly reduced in both SNL and control groups.
Neg (little) Gene_expression (produced) of Abeta in filaments associated with c fibre, adelta and abeta
4) Confidence 0.57 Published 2004 Journal Brain Res. Section Abstract Doc Link 15306240 Disease Relevance 0.65 Pain Relevance 0.88
A positive correlation was found between individual TFLs and beta-ELIR levels in the PAG but not in the hypothalamus and the pituitary.
Gene_expression (levels) of beta-ELIR in pituitary associated with periaqueductal grey
5) Confidence 0.55 Published 1989 Journal Physiol. Behav. Section Abstract Doc Link 2530600 Disease Relevance 0.61 Pain Relevance 0.45
KP at 5% or 10% clearly decreased the PCl-augmented expression of major histocompatibility complex class II and CD86 on LCs.
Gene_expression (expression) of histocompatibility complex class II in CD86
6) Confidence 0.45 Published 2008 Journal Br. J. Dermatol. Section Body Doc Link 18565185 Disease Relevance 0 Pain Relevance 0
In NCT rats, however, SG neurons exhibiting C-fiber-mediated EPSCs decreased to 7% (3 of 41 neurons tested), whereas Abeta-fiber EPSCs were observed in 21 (51%) of the neurons, and 14 (67%) of them exhibited monosynaptic ones.
Gene_expression (observed) of Abeta in neurons associated with c fibre, substantia gelatinosa and abeta
7) Confidence 0.32 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 14648598 Disease Relevance 0 Pain Relevance 1.20
This antigen presenting phenotype stimulates the adaptive immune response, characterized by increased major histocompatibility complex II (MHCII) expression and CD11c positive cells [34,36].
Gene_expression (expression) of major histocompatibility complex II
8) Confidence 0.25 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2329612 Disease Relevance 0.19 Pain Relevance 0.11
It is known that macrophages, which express major histocompatibility complex class II molecules, present non-self antigens to T-cell receptors on Th1 cells.
Gene_expression (express) of major histocompatibility complex class II in Th1 cells
9) Confidence 0.23 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 1.73 Pain Relevance 0.60
-receptor 2 expression on peripheral blood mononuclear cells; downregulation of major histocompatibility complex class II expression on virus-infected cells and tumour cells; activation of natural killer cells; downregulation of several adhesion molecules; and enhancement of soluble adhesion molecules in serum.
Gene_expression (expression) of major histocompatibility complex class II in blood associated with cancer and adhesions
10) Confidence 0.20 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 1.32 Pain Relevance 0.34
The highly selective non-equilibrium mu-antagonist beta-funaltrexamine (beta-FNA) produced a maximal 20-fold shift in the IC50 for the mu-agonist morphine on the guinea-pig ileum preparation, whilst producing no significant change in the IC50 for the kappa-agonist ethylketazocine.
Gene_expression (produced) of beta-FNA in ileum associated with antagonist, agonist and morphine
11) Confidence 0.18 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6295778 Disease Relevance 0 Pain Relevance 0.64
These findings are in agreement with previous studies stating that the efficiency of the IAB is limited in highly compliant aortas.24
Gene_expression (efficiency) of IAB in aortas
12) Confidence 0.15 Published 2010 Journal The Journal of Thoracic and Cardiovascular Surgery Section Body Doc Link PMC2891860 Disease Relevance 0.06 Pain Relevance 0
Vtip has been quantified in vitro in a straight latex tube for different IAB sizes, and it was approximately 57% of the nominal balloon volume.15 Head pressure was 24 mm Hg, and the IAB was operated from standstill.
Gene_expression (sizes) of IAB in Head
13) Confidence 0.15 Published 2010 Journal The Journal of Thoracic and Cardiovascular Surgery Section Body Doc Link PMC2891860 Disease Relevance 0.33 Pain Relevance 0.05
Both beta-FNA and RX8008M produced some antagonism of bremazocine, ethyl-ketocyclazocine, proxorphan and butorphanol, indicating that these agonists have a prominent mu-receptor component to their antinociceptive actions.
Gene_expression (produced) of beta-FNA associated with agonist, butorphanol and antinociceptive
14) Confidence 0.11 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 3216959 Disease Relevance 0 Pain Relevance 1.03
Lignocaine produced dose-dependent inhibitions of the C-, A-delta and A-beta evoked responses of the cells which became more selective for the noxious evoked responses as the dose increased.
Gene_expression (produced) of A-beta
15) Confidence 0.09 Published 1992 Journal Pain Section Abstract Doc Link 1594281 Disease Relevance 0.16 Pain Relevance 0.76
Furthermore, in the present study, passing of an electric current through acupuncture needles showed that excitation of group III (Adelta) and group IV (C) afferent fibers in the somatic nerve was capable of producing an increase in CBF, whereas excitation of group I (Aalpha) and group II (Abeta) fibers was ineffective.
Gene_expression (excitation) of Abeta in nerve associated with adelta, acupuncture and abeta
16) Confidence 0.06 Published 2000 Journal Jpn. J. Physiol. Section Abstract Doc Link 11120916 Disease Relevance 0 Pain Relevance 0.29
Thus, the adenomyotic stromal tissue contained numerous monocyte-lineage cells with higher expression levels of ibeta1, one of their products.
Gene_expression (expression) of ibeta1 in monocyte associated with dismenorea
17) Confidence 0.06 Published 2003 Journal Life Sci. Section Abstract Doc Link 12798416 Disease Relevance 0.78 Pain Relevance 0.70
A series of ester homologues 2-5 of the mu receptor nonequilibrium antagonist beta-funaltrexamine (1, beta-FNA) was synthesized.
Gene_expression (synthesized) of beta-FNA associated with antagonist
18) Confidence 0.05 Published 1986 Journal J. Med. Chem. Section Abstract Doc Link 3020246 Disease Relevance 0 Pain Relevance 0.42
They also were able to detect a significant increase in fibrinogen (P= 0.005) and C-reactive protein levels (P= 0.025) in patients with high levels of GAD 65 and/or IA-2 autoantibodies as compared with antibody negative patients and control subjects. [104]
Gene_expression (autoantibodies) of IA-2 associated with generalized anxiety disorder
19) Confidence 0.04 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.56 Pain Relevance 0.11
They also were able to detect a significant increase in fibrinogen (P= 0.005) and C-reactive protein levels (P= 0.025) in patients with high levels of GAD 65 and/or IA-2 autoantibodies as compared with antibody negative patients and control subjects. [104]
Gene_expression (/) of IA-2 associated with generalized anxiety disorder
20) Confidence 0.04 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.55 Pain Relevance 0.11

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