INT3703

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 1977
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 38
Total Number 38
Disease Relevance 11.43
Pain Relevance 9.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Grhpr) cytoplasm (Grhpr)
Anatomy Link Frequency
plasma 4
RVLM 2
liver 2
colon 2
Bile duct 2
Grhpr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 7 100.00 Very High Very High Very High
depression 4 100.00 Very High Very High Very High
Clonidine 8 99.98 Very High Very High Very High
Paracetamol 24 99.84 Very High Very High Very High
Gabapentin 6 99.78 Very High Very High Very High
Inflammation 2 99.40 Very High Very High Very High
Rostral ventrolateral medulla 22 99.24 Very High Very High Very High
Pain 7 99.20 Very High Very High Very High
qutenza 15 99.16 Very High Very High Very High
ischemia 2 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 4 100.00 Very High Very High Very High
Heart Rate Under Development 1 99.52 Very High Very High Very High
INFLAMMATION 9 99.40 Very High Very High Very High
Hyperglycemia 4 99.38 Very High Very High Very High
Pain 6 99.20 Very High Very High Very High
Cv Unclassified Under Development 2 99.12 Very High Very High Very High
Pressure Volume 2 Under Development 4 99.08 Very High Very High Very High
Nociception 7 99.04 Very High Very High Very High
Cyanosis 4 99.00 Very High Very High Very High
Diabetic Neuropathy 6 98.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With 20 mM APAP and an inhibition of glutathione reductase by 1.3-(2-chloroethyl)-1-nitrosourea (BCNU), protein thiols were depleted by 40% by arylation and the formation of glutathione mixed disulfides, again without a loss of viability.
Negative_regulation (inhibition) of reductase associated with paracetamol
1) Confidence 0.50 Published 1990 Journal Biochem. Pharmacol. Section Abstract Doc Link 2403376 Disease Relevance 0.06 Pain Relevance 0.65
3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) is a highly-hydrophobic small molecule that was originally developed for cancer therapy (Triapine, Vion Pharmaceuticals) due to its ability to inhibit ribonucleotide reductase, a key enzyme required for DNA synthesis. 3-AP has a high affinity for divalent cations, chelating the Fe(2+) at the R2 subunit of the enzyme and inhibiting formation of a tyrosyl radical essential for ribonucleotide reduction.
Negative_regulation (inhibit) of reductase associated with cancer
2) Confidence 0.50 Published 2006 Journal CNS Drug Rev Section Abstract Doc Link 16834759 Disease Relevance 0.37 Pain Relevance 0
This study examined the effects of hyperglycemia and treatment with the aldose reductase inhibitor, Tolrestat, on the pain behavior evoked by injection of formalin into the dorsum of a single hind paw.
Negative_regulation (inhibitor) of reductase in paw associated with hyperglycemia and pain
3) Confidence 0.37 Published 1994 Journal Pain Section Abstract Doc Link 7838591 Disease Relevance 0.47 Pain Relevance 0.17
An aldose reductase inhibitor slightly increased the nociceptive threshold at a high dose.
Negative_regulation (inhibitor) of reductase associated with nociception
4) Confidence 0.27 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11711035 Disease Relevance 0.78 Pain Relevance 0.76
These results suggest that OT-7100 alleviates hyperalgesia in a diabetic neuropathy model in a different manner from gabapentin or aldose reductase inhibitor and may be a new treatment for the pain associated with peripheral nerve injury.
Negative_regulation (inhibitor) of reductase in peripheral nerve associated with pain, hyperalgesia, nervous system injury, diabetic neuropathy, gabapentin and peripheral nerve injury
5) Confidence 0.27 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11711035 Disease Relevance 0.93 Pain Relevance 0.80
In vivo inhibition of the cerebral glutathione reductase was caused by ammonium metavanadate (12.5 mg/kg; three times a week for 6 weeks).
Negative_regulation (inhibition) of reductase
6) Confidence 0.26 Published 1992 Journal Arch. Toxicol. Section Abstract Doc Link 1514927 Disease Relevance 0 Pain Relevance 0.14
L-Buthionine-sulfoximine, an inhibitor of the GSH-synthesis, caused a marked decrease of the GSH levels in the liver, stomach, proximal small intestine, colon and rectum and a concomitant decline in GSSG-reductase activity.
Negative_regulation (decline) of GSSG-reductase in colon
7) Confidence 0.20 Published 1989 Journal Pharmacology Section Abstract Doc Link 2727048 Disease Relevance 0 Pain Relevance 0.10
Statins, widely used as clinically effective inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, exhibit anti-inflammatory properties that may be of therapeutic benefit for the management of some neurological disorders.
Negative_regulation (inhibitors) of reductase associated with neurological disease and inflammation
8) Confidence 0.16 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17286627 Disease Relevance 0.64 Pain Relevance 0.28
Fasting for 24 h significantly decreased the GSH content, GSH-aryltransferase and GSSG-reductase activities in the liver but not in the intestine, where even higher GSH concentrations were found in the proximal segments.
Negative_regulation (decreased) of GSSG-reductase in liver
9) Confidence 0.14 Published 1989 Journal Pharmacology Section Abstract Doc Link 2727048 Disease Relevance 0 Pain Relevance 0.07
Acute treatment with clonidine decreased the citrate synthase, NADH-cytochrome c reductase and cytochrome oxidase activities only in the same type of mitochondria, i.e. synaptic "heavy" mitochondria.
Negative_regulation (decreased) of reductase associated with clonidine
10) Confidence 0.08 Published 1989 Journal Farmaco Section Abstract Doc Link 2775415 Disease Relevance 0 Pain Relevance 0.48
Acute treatment with piracetam decreased citrate synthase, glutamate dehydrogenase, NADH-cytochrome c reductase and cytochrome oxidase activities only in the "heavy" mitochondria obtained from synaptosomes.
Negative_regulation (decreased) of reductase associated with glutamate
11) Confidence 0.08 Published 1989 Journal Farmaco Section Abstract Doc Link 2775415 Disease Relevance 0 Pain Relevance 0.44
L-Buthionine-sulfoximine, an inhibitor of the GSH-synthesis, caused a marked decrease of the GSH levels in the liver, stomach, proximal small intestine, colon and rectum and a concomitant decline in GSSG-reductase activity.
Negative_regulation (decline) of GSSG-reductase in small intestine
12) Confidence 0.07 Published 1989 Journal Pharmacology Section Abstract Doc Link 2727048 Disease Relevance 0 Pain Relevance 0.10
L-Buthionine-sulfoximine, an inhibitor of the GSH-synthesis, caused a marked decrease of the GSH levels in the liver, stomach, proximal small intestine, colon and rectum and a concomitant decline in GSSG-reductase activity.
Negative_regulation (decline) of GSSG-reductase in rectum
13) Confidence 0.07 Published 1989 Journal Pharmacology Section Abstract Doc Link 2727048 Disease Relevance 0 Pain Relevance 0.10
Reduction products of NAPQI and its dimethylated analogues were not important contributors to cytotoxicity or GSSG formation based on the following results: 1) the quinone imines did not increase oxygen consumption by hepatocytes nor did they lead to oxygen uptake in solution; 2) dicoumarol, an inhibitor of the reductase, DT-diaphorase, had no effect on cytotoxicity caused by the quinone imines.
Negative_regulation (inhibitor) of reductase in hepatocytes
14) Confidence 0.06 Published 1988 Journal Mol. Pharmacol. Section Abstract Doc Link 3173335 Disease Relevance 0 Pain Relevance 0
These data demonstrate that a novel peptide may protect against the slowing of nerve conduction in prolonged diabetes and that the mechanism of action is unrelated to aldose reductase inhibition, prevention of nerve ischemia, or axonal atrophy.
Negative_regulation (inhibition) of reductase in nerve associated with diabetes mellitus, ischemia and frailty
15) Confidence 0.05 Published 1998 Journal Metab. Clin. Exp. Section Abstract Doc Link 9627361 Disease Relevance 0.95 Pain Relevance 0.22
The more severe type II form is associated with a global deficiency of cytochrome b(5) reductase and is characterized by cyanosis with neurological dysfunction.
Negative_regulation (deficiency) of reductase associated with anesthesia and cyanosis
16) Confidence 0.04 Published 2006 Journal Blood Cells Mol. Dis. Section Abstract Doc Link 16310381 Disease Relevance 0.42 Pain Relevance 0.10
After removal of the NADH-cytochrome b(5) reductase, the plasma membranes retained a doxorubicin-inhibited NADH-quinone reductase activity.
Negative_regulation (removal) of reductase in plasma
17) Confidence 0.03 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11875069 Disease Relevance 0.08 Pain Relevance 0.09
The doxorubicin-inhibited NADH-quinone reductase may provide a target for the anthracycline antitumor agents and a candidate ferricyanide reductase for plasma membrane electron transport.
Negative_regulation (inhibited) of reductase in plasma
18) Confidence 0.03 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11875069 Disease Relevance 0.19 Pain Relevance 0
A doxorubicin-inhibited NADH-quinone reductase was characterized and purified from plasma membranes of rat liver.
Negative_regulation (inhibited) of reductase in liver
19) Confidence 0.03 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11875069 Disease Relevance 0.09 Pain Relevance 0.10
After removal of the NADH-cytochrome b(5) reductase, the plasma membranes retained a doxorubicin-inhibited NADH-quinone reductase activity.
Negative_regulation (inhibited) of reductase in plasma
20) Confidence 0.03 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11875069 Disease Relevance 0.07 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox