INT37037

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Context Info
Confidence 0.50
First Reported 1987
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 5.75
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ANTXR2) endoplasmic reticulum (ANTXR2) plasma membrane (ANTXR2)
Anatomy Link Frequency
retina 1
capillary 1
ANTXR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 11 100.00 Very High Very High Very High
COX-2 inhibitor 2 99.44 Very High Very High Very High
qutenza 5 98.12 Very High Very High Very High
Pain 1 88.24 High High
Central nervous system 3 76.32 Quite High
dopamine receptor 3 75.08 Quite High
Stabbing pain 1 71.84 Quite High
anesthesia 34 67.84 Quite High
Enkephalin 1 66.60 Quite High
Neuropeptide 1 51.52 Quite High
Disease Link Frequency Relevance Heat
Hypertension 534 100.00 Very High Very High Very High
Headache 8 100.00 Very High Very High Very High
Adhesions 2 100.00 Very High Very High Very High
Systemic Hyalinosis 5 99.96 Very High Very High Very High
Disease 25 99.88 Very High Very High Very High
Chronic Renal Insufficiency 6 98.48 Very High Very High Very High
Renal Insufficiency 6 94.28 High High
Arthralgia 1 88.24 High High
Stroke 70 87.64 High High
Contracture 1 87.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, mutations in the capillary morphogenesis gene-2 (CMG-2), a transmembrane protein with important roles in cell-cell adhesion and cell-extracellular matrix interactions, have been shown to cause ISH.
Positive_regulation (cause) of capillary morphogenesis gene-2 in capillary associated with systemic hyalinosis and adhesions
1) Confidence 0.50 Published 2004 Journal Clin. Dysmorphol. Section Abstract Doc Link 15365459 Disease Relevance 0.79 Pain Relevance 0.09
We concluded that cerebrovascular diseases (CD) can lead to ISH and that the COX-2 inhibitor can be an effective prophylactic drug for ISH after CD.
Positive_regulation (lead) of ISH associated with cox-2 inhibitor, headache and disease
2) Confidence 0.49 Published 2002 Journal Cephalalgia Section Abstract Doc Link 12047458 Disease Relevance 1.20 Pain Relevance 0.83
In the more differentiated central retina, a narrower band of Clrn1 ISH-positive cells (Figure 3I) is apparent, and some of these cells also stain positively for Sox9 (Figure 3J; red) and Glast (Figure 3J; green).
Positive_regulation (band) of ISH in retina
3) Confidence 0.49 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0 Pain Relevance 0
Moreover, interferences between ISH coupled to ICC techniques may occur leading to artifactual signals.
Positive_regulation (coupled) of ISH
4) Confidence 0.30 Published 1997 Journal Brain Res. Brain Res. Protoc. Section Abstract Doc Link 9385084 Disease Relevance 0 Pain Relevance 0.19
The prediction power of ISH was a 30% increase in the likelihood of an adverse outcome (odd ratio 1.3; 95% CI, 1.1-1.6).
Positive_regulation (increase) of ISH associated with hypertension
5) Confidence 0.26 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 1.01 Pain Relevance 0.04
Treatment of ISH and the reduction of Cardiovascular Events
Positive_regulation (Treatment) of ISH associated with hypertension
6) Confidence 0.25 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 1.92 Pain Relevance 0
The current work of the PROMISE study will be the stepping-stone toward answering the question; is the perioperative ISH a cardiac risk factor?



Positive_regulation (perioperative) of ISH associated with hypertension
7) Confidence 0.25 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2774582 Disease Relevance 0.75 Pain Relevance 0.07
Slight increases in ODC activity by CSC (10 micrograms/ml), CSC (1 microgram/ml) with ethanol, and T-2 toxin (1 nM) were observed, but PA activity was not affected by these compounds.
Positive_regulation (increases) of T-2 toxin
8) Confidence 0.08 Published 1987 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 3469455 Disease Relevance 0.07 Pain Relevance 0.34

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