INT37057

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.76
First Reported 1987
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 7.98
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tlx2) DNA binding (Tlx2) cytoplasm (Tlx2)
Anatomy Link Frequency
myocardium 2
spinal cord 1
spinal cord dorsal columns 1
Tlx2 (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 230 100.00 Very High Very High Very High
Spinal cord 9 98.36 Very High Very High Very High
headache 1 91.12 High High
sodium channel 15 90.20 High High
Nav1.6 3 75.00 Quite High
Multiple sclerosis 6 69.88 Quite High
cINOD 42 68.52 Quite High
imagery 26 55.04 Quite High
Catecholamine 12 38.80 Quite Low
Inflammation 52 33.28 Quite Low
Disease Link Frequency Relevance Heat
Injury 23 99.64 Very High Very High Very High
Alzheimer's Dementia 27 99.60 Very High Very High Very High
Chlamydia Infection 8 99.40 Very High Very High Very High
Ovarian Cancer 66 98.88 Very High Very High Very High
Cancer 200 98.36 Very High Very High Very High
Multiple Sclerosis 21 97.76 Very High Very High Very High
Atherosclerosis 70 93.76 High High
Experimental Autoimmune Encephalomyelitis 3 92.92 High High
Adverse Drug Reaction 1 92.64 High High
Headache 1 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of the 18 patients evaluated in this clinical trial, 15 (83%) responded well, and ENX was effective in 3 of the 5 Chlamydia positive cases and in 12 of the 13 Chlamydia-negative patients.
Gene_expression (effective) of ENX associated with chlamydia infection
1) Confidence 0.76 Published 1987 Journal Hinyokika Kiyo Section Abstract Doc Link 3473920 Disease Relevance 0.90 Pain Relevance 0.09
Based on the hypothesis that the co-localization of Na(v)1.6 and NCX along extensive regions of demyelinated axons may predispose these axons to injury, we examined the expression of myelin basic protein, Na(v)1.2, Na(v)1.6, NCX and beta-amyloid precursor protein (beta-APP), a marker of axonal injury, in the spinal cord dorsal columns of mice with EAE.
Spec (examined) Gene_expression (expression) of NCX in spinal cord dorsal columns associated with multiple sclerosis, alzheimer's dementia, injury and spinal cord
2) Confidence 0.64 Published 2004 Journal Brain Section Abstract Doc Link 14662515 Disease Relevance 1.01 Pain Relevance 0.43
Our results indicate that co-expression of Na(v)1.6 and NCX is associated with axonal injury in the spinal cord in EAE.
Gene_expression (co-expression) of NCX in spinal cord associated with multiple sclerosis, injury and spinal cord
3) Confidence 0.50 Published 2004 Journal Brain Section Abstract Doc Link 14662515 Disease Relevance 0.85 Pain Relevance 0.33
Using triple-labelled fluorescent immunohistochemistry, we demonstrate that 73.5 +/- 4.3% of beta-APP positive axons co-express Na(v)1.6 and NCX, compared with 4.4 +/- 1.0% in beta-APP negative axons.
Gene_expression (co-express) of NCX
4) Confidence 0.43 Published 2004 Journal Brain Section Abstract Doc Link 14662515 Disease Relevance 0.68 Pain Relevance 0.34
Given that intracellular Ca2+ homeostasis is tightly regulated by a cascade of intracellular Ca2+ regulatory proteins including SERCA, phospholamban (PLB) and NCX [18], Western blot analysis was performed to evaluate the expression of SERCA2a, PLB and NCX.
Gene_expression (expression) of NCX
5) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.24 Pain Relevance 0
Our results shown in Fig. 5 revealed a significantly reduced expression of PLB associated with unchanged SERCA2a and NCX in myocardium from APP/PS1 mice compared with the WT group.
Gene_expression (expression) of NCX in myocardium
6) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.26 Pain Relevance 0
The unchanged intracellular Ca2+ decay coincides with the normal TR50 and TR90 in APP/PS1 mouse cardiomyocytes, which is also supported by the normal protein levels of SERCA2a and NCX, the main machineries to remove Ca2+ from cytosolic space for cardiac relaxation to occur, in APP/PS1 myocardium.
Gene_expression (levels) of NCX in myocardium
7) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.31 Pain Relevance 0
1,000), rabbit anti-Na+-Ca2+ exchanger (NCX, 1?
Gene_expression (exchanger) of NCX
8) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0 Pain Relevance 0
However, a slightly increased intensity of positive immunostaining was seen at the bifurcation of carotid arteries of mice treated with NCX 4016 compared with control mice (p?
Gene_expression (treated) of NCX
9) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943480 Disease Relevance 0.12 Pain Relevance 0.27
Neither NCX 4016 nor high dose ASA had an effect on the expression levels of eNOS (Figure 4E).


Gene_expression (expression) of NCX associated with aspirin
10) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943480 Disease Relevance 0.18 Pain Relevance 0.32
In the in vitro studies, aspirin and NCX 4042 did not induce an effect on any of the cell lines, whereas NCX 4040 produced a marked cytostatic dose-related effect, indicating a pivotal role of the -NO2 group.
Gene_expression (produced) of NCX associated with aspirin
11) Confidence 0.09 Published 2005 Journal J Transl Med Section Abstract Doc Link PMC549525 Disease Relevance 0.86 Pain Relevance 0.28
Neither aspirin nor the denitrated analog, NCX 4042, influenced the growth of any of the cell lines studied, whereas NCX 4040 produced an important cytocidal effect.
Gene_expression (produced) of NCX associated with aspirin
12) Confidence 0.09 Published 2005 Journal J Transl Med Section Body Doc Link PMC549525 Disease Relevance 0.95 Pain Relevance 0.15
The results clearly demonstrated a cause/effect advantage of thiol utilization/depletion by NCX-4040-mediated NO generation in the cisplatin-resistant ovarian carcinoma.
Neg (NO) Gene_expression (generation) of NCX-4040 associated with ovarian cancer
13) Confidence 0.02 Published 2008 Journal J Transl Med Section Body Doc Link PMC2267444 Disease Relevance 0.44 Pain Relevance 0.03
Aspirin (ASA), a metabolic product of NCX-4040, did not show any significant effect on tumor growth volume (Figure 4B).
Gene_expression (product) of NCX-4040 associated with aspirin and cancer
14) Confidence 0.02 Published 2008 Journal J Transl Med Section Body Doc Link PMC2267444 Disease Relevance 1.19 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox