INT37076

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Context Info
Confidence 0.14
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.77
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (KNG1) extracellular region (KNG1) plasma membrane (KNG1)
Anatomy Link Frequency
nociceptors 2
KNG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 28 100.00 Very High Very High Very High
substance P 1 99.92 Very High Very High Very High
nociceptor 1 99.60 Very High Very High Very High
b2 receptor 8 98.04 Very High Very High Very High
Analgesic 5 92.72 High High
Inflammation 8 89.52 High High
antagonist 4 85.68 High High
Arthritis 6 82.60 Quite High
Inflammatory mediators 1 78.52 Quite High
adenocard 1 72.08 Quite High
Disease Link Frequency Relevance Heat
Hereditary Angioedema 91 99.86 Very High Very High Very High
Hyperalgesia 1 99.00 Very High Very High Very High
Respiratory Sounds 1 97.00 Very High Very High Very High
Urticaria 2 96.48 Very High Very High Very High
Hypersensitivity 2 95.12 Very High Very High Very High
Targeted Disruption 2 93.12 High High
Overactive Bladder 5 91.48 High High
INFLAMMATION 10 89.52 High High
Edema 51 83.68 Quite High
Arthritis 8 82.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another approach to treating HAE is by inhibiting the ability of bradykinin to bind to and signal through its cognate receptor, the bradykinin B2 receptor.
Negative_regulation (inhibiting) of bradykinin Binding (bind) of associated with hereditary angioedema, b2 receptor and bradykinin
1) Confidence 0.14 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2921104 Disease Relevance 1.00 Pain Relevance 0.33
Mepacrine, a phospholipase A2 inhibitor, more potently inhibited the bradykinin- and ATP-induced contractions than the ACh-induced one.
Negative_regulation (inhibited) of bradykinin Binding (contractions) of associated with bradykinin
2) Confidence 0.13 Published 1987 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 3475493 Disease Relevance 0.30 Pain Relevance 0.36
This seems to be mediated both directly through inhibition of nociceptors and indirectly via decreasing the synthesis of or binding to bradykinin, substance P, and other hyperalgesic compounds.25–28
Negative_regulation (decreasing) of bradykinin Binding (binding) of in nociceptors associated with hyperalgesia, nociceptor, bradykinin and substance p
3) Confidence 0.07 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004631 Disease Relevance 0.46 Pain Relevance 0.62

General Comments

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